Matthew R. Grace
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View article: Confirming Rupture of Membranes with Intra-Amniotic Fluorescein Dye Test
Confirming Rupture of Membranes with Intra-Amniotic Fluorescein Dye Test Open
We describe two patients presenting with preterm loss of fluid and inconclusive evaluations requiring further assessment. Patient 1 was a 41-year-old G3P1011 at 216/7 weeks; Patient 2 was a 22-year-old G2P1001 at 315/7 weeks. In both, pret…
View article: Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis Open
Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1 , SPTB , and EPB41 . These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestratio…
View article: Outcomes in the immediate subsequent gestation following a pregnancy complicated by previable preterm prelabor rupture of membranes
Outcomes in the immediate subsequent gestation following a pregnancy complicated by previable preterm prelabor rupture of membranes Open
Objective Little is known about outcomes of subsequent gestation following a pregnancy complicated by previable/periviable preterm prelabor rupture of membrane (pPPROM). The objective of this study is to describe outcomes in subsequent ges…
View article: Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes
Prophylactic Antibiotics in Twin Pregnancies Complicated by Previable Preterm Premature Rupture of Membranes Open
OBJECTIVE: This study aims to determine if antibiotics given for latency to women with twins and previable preterm premature rupture of membranes (PPROM) affect the duration from membrane rupture to delivery. METHODS: A retrospective cohor…
View article: Novel premature termination codon in the <i>FOXP3</i> gene as the cause of familial hydrops fetalis in males
Novel premature termination codon in the <i>FOXP3</i> gene as the cause of familial hydrops fetalis in males Open
A 19‐year‐old, G1P0, pregnant person was referred at 20w2d gestation for evaluation due to non‐immune hydrops fetalis (NIHF), which was confirmed at the time of evaluation. Amniocentesis was performed at 20 w4d, and FISH, karyotype, chromo…
View article: A Large Thyroid Goiter in a Newborn With Congenital Hypothyroidism: Timeline for Decrease in Size of Thyroid
A Large Thyroid Goiter in a Newborn With Congenital Hypothyroidism: Timeline for Decrease in Size of Thyroid Open
Congenital hypothyroidism rarely causes a clinically significant neck mass in newborns. We present the case of a newborn with congenital hypothyroidism and significantly enlarged goiter and discuss imaging considerations and medical and su…
View article: Sex-Dependent Differences in Mouse Placental Gene Expression following a Maternal High-Fat Diet
Sex-Dependent Differences in Mouse Placental Gene Expression following a Maternal High-Fat Diet Open
Objective In utero fetal exposures may have sex-specific placental gene responses. Our objective was to measure sex-based differences in placental gene expression from dams fed high-fat diet (HFD) versus control diet (CD). Study Design We …
View article: Title: The Quality and Content of YouTube Videos About Herpes Simplex Virus (HSV) in Pregnancy: a Retrospective Review (Preprint)
Title: The Quality and Content of YouTube Videos About Herpes Simplex Virus (HSV) in Pregnancy: a Retrospective Review (Preprint) Open
BACKGROUND Pregnant individuals often seek online information regarding health concerns on free and accessible platforms such as YouTube. Use of supplemental information may increase when pregnancy is complicated by diagnoses of sexually …
View article: Epigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway
Epigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway Open
Preeclampsia is a potentially fatal pregnancy disorder affecting millions of women around the globe. Dysregulation in gene and protein expression within key biological pathways controlling angiogenesis has been implicated in the developmen…
View article: Management of pregnancy and survival of infants with trisomy 13 or trisomy 18
Management of pregnancy and survival of infants with trisomy 13 or trisomy 18 Open
Objective The objective of this study was to describe antenatal/intrapartum management and survival of liveborn infants with known trisomy 13 (T13) or trisomy 18 (T18) based on planned neonatal care. Study Design This is a retrospective co…
View article: Debunking the Myth: Do Maternal-Fetal Medicine Fellows Negatively Impact Resident Obstetrical Skills?
Debunking the Myth: Do Maternal-Fetal Medicine Fellows Negatively Impact Resident Obstetrical Skills? Open
Objective Residency applicants often express concern that fellows negatively impact surgical opportunities, especially with less common procedures. We sought to describe the impact of maternal-fetal medicine (MFM) fellows on resident surgi…
View article: Cell-Free DNA Screening: Complexities and Challenges of Clinical Implementation
Cell-Free DNA Screening: Complexities and Challenges of Clinical Implementation Open
Screening for fetal aneuploidy in pregnant women using cell-free DNA has increased dramatically since the technology became commercially available in 2011. Since that time, numerous trials have demonstrated high sensitivity and specificity…
View article: miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia
miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia Open
Preeclampsia (PE) is a pregnancy disorder characterized by high blood pressure and proteinuria that can cause adverse health effects in both mother and fetus. There is no current cure for PE other than delivery of the fetus. While the etio…
View article: Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period
Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period Open
Sex-based differences in response to adverse prenatal environments and infant outcomes have been observed, yet the underlying mechanisms for this are unclear. The placental epigenome may be a driver of these differences.
View article: Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice
Effect of a High-Fat Diet and Metformin on Placental mTOR Signaling in Mice Open
Objective This study was aimed to measure the effects of a high-fat diet and metformin on placental mechanistic target of rapamycin (mTOR) signaling in mice. Study Design Pregnant friend virus B (FVB)-strain mice were allocated on embryoni…