Matthew Halvorsen
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View article: Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches Open
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap…
View article: Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches Open
Background Genetic ancestry is an important factor to account for in DNA methylation studies because genetic variation influences DNA methylation patterns. One approach uses principal components (PCs) calculated from CpG sites that overlap…
View article: Persistent Tic Disorders Are Associated With 17q12 Duplications
Persistent Tic Disorders Are Associated With 17q12 Duplications Open
Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are childhood-onset neuropsychiatric conditions with high heritability. Due to current sample size limitations, identifying TS/PTD risk genes has been challenging. This study address…
View article: Methylome-Wide Association Study of Obsessive-Compulsive Disorder
Methylome-Wide Association Study of Obsessive-Compulsive Disorder Open
Background Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition influenced by both genetic and environmental risk factors. Epigenetic modifications, such as DNA methylation, may offer insights into biologically meani…
View article: Genomic Analysis of Trichotillomania
Genomic Analysis of Trichotillomania Open
Trichotillomania (TTM) is a psychiatric condition in which people feel an overwhelming urge to pull out their hair, resulting in noticeable hair loss and significant distress. Twin and family studies suggest that TTM is at least partly gen…
View article: Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety
Polygenic scores and symptom severity change after internet-delivered cognitive behaviour therapy for depression and anxiety Open
View article: Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety
Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety Open
Background Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Ide…
View article: Optimizing Genetic Ancestry Adjustment in DNA Methylation Studies: A Comparative Analysis of Approaches
Optimizing Genetic Ancestry Adjustment in DNA Methylation Studies: A Comparative Analysis of Approaches Open
View article: Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder Open
View article: Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder
Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder Open
A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform…
View article: Genomic Analysis of Trichotillomania
Genomic Analysis of Trichotillomania Open
Trichotillomania (TTM) is a psychiatric condition in which people feel an overwhelming urge to pull out their hair, resulting in noticeable hair loss and significant distress. Twin, family and candidate gene studies suggest that TTM is at …
View article: A burden of rare copy number variants in obsessive-compulsive disorder
A burden of rare copy number variants in obsessive-compulsive disorder Open
View article: A burden of rare copy number variants in obsessive-compulsive disorder
A burden of rare copy number variants in obsessive-compulsive disorder Open
View article: Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders
Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders Open
View article: Educational attainment polygenic risk score and symptom severity change after Internet-delivered cognitive behaviour therapy for depression and anxiety
Educational attainment polygenic risk score and symptom severity change after Internet-delivered cognitive behaviour therapy for depression and anxiety Open
Depressive and anxiety disorders are among the leading causes of disability worldwide. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable propo…
View article: Genomics of severe and treatment‐resistant obsessive–compulsive disorder treated with deep brain stimulation: A preliminary investigation
Genomics of severe and treatment‐resistant obsessive–compulsive disorder treated with deep brain stimulation: A preliminary investigation Open
Individuals with severe and treatment-resistant obsessive-compulsive disorder (trOCD) represent a small but severely disabled group of patients. Since trOCD cases eligible for deep brain stimulation (DBS) probably comprise the most severe …
View article: Genomics of severe and treatment‐resistant obsessive–compulsive disorder treated with deep brain stimulation: A preliminary investigation
Genomics of severe and treatment‐resistant obsessive–compulsive disorder treated with deep brain stimulation: A preliminary investigation Open
Individuals with severe and treatment‐resistant obsessive‐compulsive disorder (trOCD) represent a small but severely disabled group of patients. Since trOCD cases eligible for deep brain stimulation (DBS) probably comprise the most severe …
View article: Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety
Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety Open
Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not experience sufficient symptom relief. Identifying…
View article: Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder Open
Obsessive-compulsive disorder (OCD) affects ∼1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identif…
View article: Genome-wide association study identifies new loci associated with OCD
Genome-wide association study identifies new loci associated with OCD Open
To date, four genome-wide association studies (GWAS) of obsessive-compulsive disorder (OCD) have been published, reporting a high single-nucleotide polymorphism (SNP)-heritability of 28% but finding only one significant SNP. A sub-stantial…
View article: A Burden of Rare Copy Number Variants in Obsessive-Compulsive Disorder
A Burden of Rare Copy Number Variants in Obsessive-Compulsive Disorder Open
View article: ARFID Genes and Environment (ARFID-GEN): study protocol
ARFID Genes and Environment (ARFID-GEN): study protocol Open
Background The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults.MethodsA total of 3,000 …
View article: ARFID Genes and Environment (ARFID-GEN): study protocol
ARFID Genes and Environment (ARFID-GEN): study protocol Open
Background The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods A total of 3,00…
View article: Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol Open
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol
Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol Open
Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)
Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) Open
Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structur…
View article: Arfid Genes and Environment (ARFID-GEN): Study Protocol
Arfid Genes and Environment (ARFID-GEN): Study Protocol Open
Background The Avoidant Restrictive Food Intake Disorder Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods A total of 3,000 …
View article: Genomics of severe and treatment-resistant obsessive-compulsive disorder treated with deep brain stimulation: a preliminary investigation
Genomics of severe and treatment-resistant obsessive-compulsive disorder treated with deep brain stimulation: a preliminary investigation Open
Individuals with severe and treatment-resistant obsessive-compulsive disorder (trOCD) represent a small but severely disabled group of patients. Since trOCD cases eligible for deep brain stimulation (DBS) probably comprise the most severe …
View article: Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol
Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol Open
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and mi…
View article: Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome Open