Matthew Hird
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View article: Design and Development of PET radiotracers for Imaging Oligodendrocyte Progenitor Cells
Design and Development of PET radiotracers for Imaging Oligodendrocyte Progenitor Cells Open
View article: Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets
Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets Open
In schizophrenia, anterior hippocampus (aHipp) overactivity is associated with orbitofrontal cortex (OFC) dysfunction, but the contribution to symptomatology is unknown. In rodents, degradation of the hippocampal perineuronal net (PNN) rep…
View article: Automated radiosynthesis of [<sup>18</sup>F]CETO, a PET radiotracer for imaging adrenal glands, on Synthra RNplus
Automated radiosynthesis of [<sup>18</sup>F]CETO, a PET radiotracer for imaging adrenal glands, on Synthra RNplus Open
Primary aldosteronism (PA) is the leading secondary cause of hypertension. Determining whether one (unilateral) or both (bilateral) adrenal glands are the source of PA in a patient remains challenging, and yet it is a critical step in the …
View article: Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971
Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971 Open
Purpose Positron emission tomography (PET) studies with radioligands for 18-kDa translocator protein (TSPO) have been instrumental in increasing our understanding of the complex role neuroinflammation plays in disorders affecting the brain…
View article: Radiosynthesis of (<i>R</i>,<i>S</i>)‐[<sup>18</sup>F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971
Radiosynthesis of (<i>R</i>,<i>S</i>)‐[<sup>18</sup>F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971 Open
Translocator protein (TSPO) is a biomarker of neuroinflammation, which is a hallmark of many neurodegenerative diseases and has been exploited as a positron emission tomography (PET) target. Carbon‐11‐labelled PK11195 remains the most appl…