Explanipedia

Brain-wide single-neuron bases of working memory for sounds in humans Open

Joel I. Berger, Alexander J. Billig, Phillip E. Gander, Christopher K. Kovach, Ariane E. Rhone , et al. · 2025

In order to understand the constantly changing acoustic world our brains must maintain elements of auditory scenes in memory. The neural mechanisms for this fundamental process remain unclear. Here, we report human intracranial recordings …

Author response: Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2025

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2025

Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhan…

Clinical and Radiological Differentiation of Thoracic Spinal Meningiomas and Schwannomas: Insights From the Sapporo-Iowa Joint Study Open

Satoka Shidoh, Kazutoshi Hida, Toru Sasamori, Ikuma Echizenya, Shunsuke Yano , et al. · 2025

Thoracic spinal meningiomas and schwannomas exhibit distinct clinical and radiological profiles. The proposed scoring system may support preoperative differentiation and decision-making.

Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain Open

Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner , et al. · 2025

Synovial Cyst of Thoracic Spine: A Systematic Literature Review and Meta-Analysis Open

Prabin Shrestha, Satoshi Yamaguchi, Jang-Bo Lee, Hiroyuki Oya, Hiroto Kawasaki , et al. · 2025

TSSC are more common in elderly males, mostly occur in the lower thoracic spine, below T7. Most of them present with myelopathy and motor weakness and are cured with resection of the cyst without the need for spinal fusion. There was no re…

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2025

Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhan…

Author response: Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2025

Reading specific memories from human neurons before and after sleep Open

Yuanyi Ding, Soraya L. S. Dunn, John J. Sakon, Zahra M. Aghajan, Yipeng Zhang , et al. · 2025

The ability to retrieve a single episode encountered just once is a hallmark of human intelligence and episodic memory[1]. Yet, decoding a specific memory from neuronal activity in the human brain remains a formidable challenge. Here, we d…

Human forebrain neural synchronization and entrainment to breathing during wakefulness, sleep, and external mechanical ventilation Open

Brian J. Dlouhy, Md Rakibul Mowla, Ariane E. Rhone, Sukhbinder Kumar, Christopher K. Kovach , et al. · 2025

Glial Contribution to the Pathogenesis of Post-Operative Delirium Revealed by Multi-omic Analysis of Brain Tissue from Neurosurgery Patients Open

Takaya Ishii, Tao Wang, Kazuki Shibata, Shota Nishitani, Takehiko Yamanashi , et al. · 2025

Post-operative delirium (POD) is a common complication after surgery especially in elderly patients, characterized by acute disturbances in consciousness and cognition, which negatively impacts long-term outcomes. Effective treatments rema…

Human insula neurons respond to simple sounds during passive listening Open

Joel I. Berger, Hiroto Kawasaki, Matthew I. Banks, Sukhbinder Kumar, Matthew A. Howard , et al. · 2025

The insula is critical for integrating sensory information from the body with that arising from the environment. Although previous studies suggest that posterior insula is sensitive to sounds, auditory response properties of insula neurons…

Depth-electrode stimulation and concurrent functional MRI in humans: Factors influencing heating with body coil transmission Open

Hiroyuki Oya, Ralph Adolphs, Matthew A. Howard, J. Michael Tyszka · 2025

Electrical-stimulation fMRI (es-fMRI) combines direct stimulation of the brain via implanted electrodes with simultaneous rapid functional magnetic resonance imaging of the evoked response. Widely used to map effective functional connectiv…

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2024

Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models and computational modelling has raised the possibility that TUS…

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2024

Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhan…

Normal Pressure Hydrocephalus in Adult Mice Causes Gait Impairment, Cognitive Deficits, and Urinary Frequency with Incontinence Open

Margaret M. Tish, Natalie A Voss, Aimee Bertolli, Miles J. Klimara, Richard J. Smith , et al. · 2024

Normal pressure hydrocephalus (NPH) is marked by enlarged cerebral ventricles with normal intracranial pressure, plus three stereotypical symptoms: gait impairment, cognitive dysfunction, and urinary frequency with urge incontinence. The n…

Lesion and lesion network localization of dysnomia after epilepsy surgery Open

Asmaa Mhanna, Joel Bruss, Joseph C. Griffis, Alyssa W Sullivan, Hiroto Kawasaki , et al. · 2024

Temporal lobe epilepsy surgery is an effective treatment option for patients with drug-resistant epilepsy. However, neurosurgery poses a risk for cognitive deficits—up to one-third of patients have a decline in naming ability following tem…

Epigenetic signals associated with delirium replicated across four independent cohorts Open

Yoshitaka Nishizawa, K. Thompson, Takehiko Yamanashi, Nadia E. Wahba, Taku Saito , et al. · 2024

Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknown. We aimed to discover reliab…

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource Open

Hugo Caffaratti, Ben Slater, Nour Shaheen, Ariane E. Rhone, Ryan Calmus , et al. · 2024

Low-intensity Transcranial Ultrasound Stimulation is a promising non-invasive technique for brain stimulation and focal neuromodulation. Research with humans and animal models has raised the possibility that TUS can be biased towards enhan…

TMS-associated auditory evoked potentials can be effectively masked: Evidence from intracranial EEG Open

Nicholas T. Trapp, Eric W. K. Tsang, Joel Bruss, Simone Russo, Phillip E. Gander , et al. · 2024

Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain Open

Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner , et al. · 2024

Background: Understanding healthy human brain function is crucial to identify and map pathological tissue within it. Whilst previous studies have mapped intracranial EEG (icEEG) from non-epileptogenic brain regions, these maps do not consi…

Temporally organized representations of reward and risk in the human brain Open

Vincent Man, Jeffrey Cockburn, Oliver Flouty, Phillip E. Gander, Masahiro Sawada , et al. · 2024

Correlation of telomere length in brain tissue with peripheral tissues in living human subjects Open

Annemarie J. Carver, Benjamin Hing, Benjamin A. Elser, Stephanie Lussier, Takehiko Yamanashi , et al. · 2024

Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere len…

(053) Penile Entrapment Due to Metal Constriction Rings: Removal, Recovery and Complications Open

Kaitlyn M Maddra, Matthew A. Howard, Andrea D. Juneau, Stephen Harrington, Rutul D. Patel , et al. · 2024

Introduction Penile incarceration due to a metal constriction ring is a rare urologic emergency. Improper ring sizing, use of makeshift rings or prolonged length of use can cause penile/penoscrotal entrapment with resulting sequelae includ…

Intracranial electrophysiology of spectrally degraded speech in the human cortex Open

Kirill V. Nourski, Mitchell Steinschneider, Ariane E. Rhone, Joel I. Berger, Emily R. Dappen , et al. · 2024

Introduction Cochlear implants (CIs) are the treatment of choice for severe to profound hearing loss. Variability in CI outcomes remains despite advances in technology and is attributed in part to differences in cortical processing. Studyi…

Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM Open