Michael Isaacson
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View article: PATH-65. MGMT homozygous deletion: A rare potential pitfall for MGMT promoter methylation testing in CNS tumors
PATH-65. MGMT homozygous deletion: A rare potential pitfall for MGMT promoter methylation testing in CNS tumors Open
MGMT is primarily inactivated via promoter methylation, but MGMT homozygous deletion (hmzdel) has been rarely reported as an alternative inactivating mechanism. Although functionally similar to a methylated MGMT promoter, MGMT hmzdel is as…