Matthew J. McNulty
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View article: Meating the moment
Meating the moment Open
View article: Nitrogen accountancy in space agriculture
Nitrogen accountancy in space agriculture Open
Food production and pharmaceutical synthesis are posited as essential biotechnologies for facilitating human exploration beyond Earth. These technologies not only offer critical green space and food agency to astronauts but also promise to…
View article: A review and outlook on expression of animal proteins in plants
A review and outlook on expression of animal proteins in plants Open
This review delves into the multifaceted technologies, benefits and considerations surrounding the expression of animal proteins in plants, emphasizing its potential role in advancing global nutrition, enhancing sustainability, while being…
View article: Nitrogen Accountancy in Space Agriculture
Nitrogen Accountancy in Space Agriculture Open
Food production and pharmaceutical synthesis are posited as essential biotechnologies for facilitating human exploration beyond Earth. These technologies not only offer critical green space and food agency to astronauts but also promise to…
View article: Space bioprocess engineering on the horizon
Space bioprocess engineering on the horizon Open
Space bioprocess engineering (SBE) is an emerging multi-disciplinary field to design, realize, and manage biologically-driven technologies specifically with the goal of supporting life on long term space missions. SBE considers synthetic b…
View article: Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification
Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification Open
The virus-based immunosorbent nanoparticle is a nascent technology being developed to serve as a simple and efficacious agent in biosensing and therapeutic antibody purification. There has been particular emphasis on the use of plant virio…
View article: Functionalizing silica sol–gel with entrapped plant virus-based immunosorbent nanoparticles
Functionalizing silica sol–gel with entrapped plant virus-based immunosorbent nanoparticles Open
View article: Space Bioprocess Engineering on the Horizon
Space Bioprocess Engineering on the Horizon Open
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we…
View article: Space Bioprocess Engineering on the Horizon
Space Bioprocess Engineering on the Horizon Open
Reinvigorated public interest in human space exploration has led to the need to address the science and engineering challenges described by NASA's Space Technology Grand Challenges (STGCs) for expanding the human presence in space. Here we…
View article: Functionalizing silica sol-gel with entrapped plant virus-based immunosorbent nanoparticles
Functionalizing silica sol-gel with entrapped plant virus-based immunosorbent nanoparticles Open
Advancements in understanding and engineering of virus-based nanomaterials (VBNs) for biomedical applications motivate a need to explore the interfaces between VBNs and other biomedically-relevant chemistries and materials. While several s…
View article: Affinity sedimentation and magnetic separation with plant-made immunosorbent nanoparticles for therapeutic protein purification
Affinity sedimentation and magnetic separation with plant-made immunosorbent nanoparticles for therapeutic protein purification Open
Summary The virus-based immunosorbent nanoparticle is a nascent technology being developed to serve as a simple and efficacious agent in biosensing and therapeutic antibody purification. There has been particular emphasis on the use of pla…
View article: Evaluating the Cost of Pharmaceutical Purification for a Long-Duration Space Exploration Medical Foundry
Evaluating the Cost of Pharmaceutical Purification for a Long-Duration Space Exploration Medical Foundry Open
There are medical treatment vulnerabilities in longer-duration space missions present in the current International Space Station crew health care system with risks, arising from spaceflight-accelerated pharmaceutical degradation and resupp…
View article: Techno-economic process modelling and Monte Carlo simulation data of uncertainty quantification in field-grown plant-based manufacturing
Techno-economic process modelling and Monte Carlo simulation data of uncertainty quantification in field-grown plant-based manufacturing Open
This data article is related to the research article, "M.J. McNulty, K. Kelada, D. Paul, S. Nandi, and K.A. McDonald, Introducing uncertainty quantification to techno-economic models of manufacturing field-grown plant-made products,…
View article: Immobilization of transgenic plant cells towards bioprinting for production of a recombinant biodefense agent
Immobilization of transgenic plant cells towards bioprinting for production of a recombinant biodefense agent Open
Transgenic rice cells ( Oryza sativa ) producing recombinant butyrylcholinesterase (BChE) as a prophylactic/therapeutic against organophosphate nerve agent poisoning, cocaine toxicity, and neurodegenerative diseases like Alzheimer's were i…
View article: Towards a Biomanufactory on Mars
Towards a Biomanufactory on Mars Open
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific an…
View article: Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry
Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry Open
There are medical treatment vulnerabilities in longer-duration space missions present in the current International Space Station crew health care system with risks, arising from spaceflight-accelerated pharmaceutical degradation and resupp…
View article: Introducing uncertainty quantification to techno-economic models of manufacturing field-grown plant-made products
Introducing uncertainty quantification to techno-economic models of manufacturing field-grown plant-made products Open
There is a growing demand for large-market natural and biotechnological products driven by shifting consumer preferences in food and calls for decentralized vaccine and medication production capabilities. The current paradigm of bioreactor…
View article: Molecular pharming to support human life on the moon, mars, and beyond
Molecular pharming to support human life on the moon, mars, and beyond Open
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical sy…
View article: Introducing Uncertainty Quantification to Techno-economic Models of Manufacturing Field-Grown Plant-Made Products
Introducing Uncertainty Quantification to Techno-economic Models of Manufacturing Field-Grown Plant-Made Products Open
There is a growing demand for large market natural and biotechnological products, for example, consumer preferences drive plant-based meat alternatives, health risks of sugar overconsumption continue to motivate alternative sweeteners, and…
View article: Bioprinting transgenic plant cells for production of a recombinant biodefense agent
Bioprinting transgenic plant cells for production of a recombinant biodefense agent Open
Transgenic rice cells ( Oryza sativa ) producing recombinant butyrylcholinesterase (BChE) as a prophylactic/therapeutic against organophosphate nerve agent poisoning, cocaine toxicity, and neurodegenerative diseases like Alzheimer’s were i…
View article: Towards a Biomanufactory on Mars
Towards a Biomanufactory on Mars Open
A crewed mission to and from Mars may include an exciting array of enabling biotechnologies that leverage inherent mass, power, and volume advantages over traditional abiotic approaches. In this perspective, we articulate the scientific an…
View article: Biotechnology and Bioengineering: Volume 117, Number 10, October 2020
Biotechnology and Bioengineering: Volume 117, Number 10, October 2020 Open
View article: Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond
Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond Open
Space missions have always assumed that the risk of spacecraft malfunction far outweighs the risk of human system failure. This assumption breaks down for longer duration exploration missions and exposes vulnerabilities in space medical sy…
View article: Technoeconomic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures
Technoeconomic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures Open
Biopharmaceutical protein production using transgenic plant cell bioreactor processes offers advantages over microbial and mammalian cell culture platforms in its ability to produce complex biologics with simple chemically defined media an…
View article: Techno-economic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures
Techno-economic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures Open
Biopharmaceutical protein production using transgenic plant cell bioreactor processes offers advantages over microbial and mammalian cell culture platforms due to the ability to produce complex biologics, use of simple chemically-defined, …
View article: Techno‐economic analysis of a plant‐based platform for manufacturing antimicrobial proteins for food safety
Techno‐economic analysis of a plant‐based platform for manufacturing antimicrobial proteins for food safety Open
Continuous reports of foodborne illnesses worldwide and the prevalence of antibiotic‐resistant bacteria mandate novel interventions to assure the safety of our food. Treatment of a variety of foods with bacteriophage‐derived lysins and bac…