Matthew J. Moulton
YOU?
Author Swipe
View article: Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication Open
View article: Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress
Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress Open
The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia upt…
View article: Alzheimer’s disease protective allele of<i>Clusterin</i>modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
Alzheimer’s disease protective allele of<i>Clusterin</i>modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication Open
Summary Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms remain largely unknown. For a strong AD-associated locus …
View article: Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities
Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities Open
View article: Autolysosomal exocytosis of lipids protect neurons from ferroptosis
Autolysosomal exocytosis of lipids protect neurons from ferroptosis Open
During oxidative stress neurons release lipids that are internalized by glia. Defects in this coordinated process play an important role in several neurodegenerative diseases. Yet, the mechanisms of lipid release and its consequences on ne…
View article: Autolysosomal exocytosis of lipids protect neurons from ferroptosis
Autolysosomal exocytosis of lipids protect neurons from ferroptosis Open
During oxidative stress neurons release lipids that are internalized by glia. Defects in this coordinated process play an important role in several neurodegenerative diseases. Yet, the mechanisms of lipid release and its consequences on ne…
View article: 'Fly-ing' from rare to common neurodegenerative disease mechanisms
'Fly-ing' from rare to common neurodegenerative disease mechanisms Open
View article: Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes Open
Significance Multiple studies have implicated dozens of risk loci that may be associated with Alzheimer’s disease (AD), but common mechanisms underlying how they may contribute to disease onset or progression remain elusive. This study ide…
View article: TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila
TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila Open
View article: Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer’s Disease-associated Genes
Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer’s Disease-associated Genes Open
Summary A growing list of Alzheimer’s disease (AD) genetic risk factors is being identified, but the contribution of these genetic mutations to disease remains largely unknown. Accumulating data support a role of lipid dysregulation and ex…
View article: Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer's Disease-Associated Genes
Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer's Disease-Associated Genes Open
View article: Regulation of BMP Signaling by O-GlcNAcylation
Regulation of BMP Signaling by O-GlcNAcylation Open
Summary Precise regulation of signal transduction is critical throughout organismal life, both for embryonic development and for adult homeostasis. To ensure proper spatio-temporal signal transduction, Bone Morphogenetic Protein (BMP) sign…
View article: Lef1-dependent hypothalamic neurogenesis inhibits anxiety
Lef1-dependent hypothalamic neurogenesis inhibits anxiety Open
While innate behaviors are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate the development of neuronal populations mediating these behaviors in diverse organisms. Here, we demonstrate that …
View article: Modeling congenital disease and inborn errors of development in<i>Drosophila melanogaster</i>
Modeling congenital disease and inborn errors of development in<i>Drosophila melanogaster</i> Open
Fly models that faithfully recapitulate various aspects of human disease and human health-related biology are being used for research into disease diagnosis and prevention. Established and new genetic strategies in Drosophila have yielded …