Jacob M. Hooker
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View article: Continuous Time Dynamics of Tau and Depressive Symptoms Across the Alzheimer’s Disease Continuum
Continuous Time Dynamics of Tau and Depressive Symptoms Across the Alzheimer’s Disease Continuum Open
Background Recent evidence suggests that early accumulation of tau in brainstem neuromodulator‐producing nuclei may contribute to neuropsychiatric symptoms (NPS) in aging and preclinical Alzheimer’s Disease (AD). We examined temporal dynam…
View article: Toward Brain NaV1.8 Imaging with [11C]Suzetrigine
Toward Brain NaV1.8 Imaging with [11C]Suzetrigine Open
Background/Objective: Acute and chronic pain affect millions of individuals, yet there are currently no molecular imaging tools to directly assess pain-related mechanisms in the central nervous system (CNS). The voltage-gated sodium channe…
View article: Multitask contrastive learning for individual dairy cow recognition across different behavior classes based on small image sets
Multitask contrastive learning for individual dairy cow recognition across different behavior classes based on small image sets Open
The objectives of this study were to (1) evaluate the You Look Only Once (YOLOv7) algorithm for group-level behavior monitoring in freestall cows, (2) propose a multitask contrastive network (MTCN) for individual cow identification from li…
View article: A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia
A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia Open
Dysregulated proteostasis and intracellular transport contribute to neurodegeneration. HDAC6, a therapeutic target of interest for neurodegenerative diseases, acts at a nexus modulating both proteostasis and intracellular transport. Inhibi…
View article: Choroid plexus alterations in autism spectrum disorder: A PET-MRI study
Choroid plexus alterations in autism spectrum disorder: A PET-MRI study Open
The choroid plexus (CP), primarily known as the production site of cerebrospinal fluid (CSF), constitutes one of the sites of the blood-CSF barrier and plays a unique role in inflammation propagation, serving as a key regulator of immune r…
View article: Age-Related Changes in Curiosity: The Influence of Locus Coeruleus on Information-Seeking Behavior
Age-Related Changes in Curiosity: The Influence of Locus Coeruleus on Information-Seeking Behavior Open
Curiosity enhances learning and memory and has been linked to the locus coeruleus (LC), which undergoes age-related decline. To examine how aging affects curiosity and information-seeking, we developed the Photographic Art Storytelling Tas…
View article: Microglia matters: visualizing the immune battle in Parkinson’s disease
Microglia matters: visualizing the immune battle in Parkinson’s disease Open
Microglia play critical roles in immune defense within the central nervous system (CNS), and microglia-mediated immune changes in the brain are observed in various neurodegenerative diseases, including Parkinson's disease (PD). While PET i…
View article: Olfactory Drug Delivery in Rodents: Deposition and Pharmacokinetics
Olfactory Drug Delivery in Rodents: Deposition and Pharmacokinetics Open
Olfactory drug delivery (ODD) is a route of administration that precisely targets the olfactory cleft, a region of the upper nasal cavity with privileged access to the brain. ODD offers better brain delivery compared to traditional intrana…
View article: Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder Open
Objective [ 18 F]EKZ‐001 is a positron emission tomography (PET) tracer targeting histone deacetylase 6 (HDAC6), an enzyme responsible for intracellular transport and clearance of misfolded proteins. HDAC6 modulation is a promising treatme…
View article: Regional skull translocator protein elevation in autistic adults detected by PET-MRI
Regional skull translocator protein elevation in autistic adults detected by PET-MRI Open
Immune processes have been implicated in the pathophysiology of autism spectrum disorder (ASD). Brain borders, such as the skull, have recently been highlighted as sites where neuro-immune interactions occur with key consequences for brain…
View article: Influence of tau pathology and anxiety and depressive symptoms on metamemory in cognitively normal older adults
Influence of tau pathology and anxiety and depressive symptoms on metamemory in cognitively normal older adults Open
Background The ability to accurately discern memory function (i.e., metamemory) decreases with age and is further diminished in Alzheimer’s disease (AD). As such, changes in metamemory may be a sensitive behavioral indicator of pre‐symptom…
View article: Influence of tau pathology and anxiety and depressive symptoms on metamemory in cognitively normal older adults
Influence of tau pathology and anxiety and depressive symptoms on metamemory in cognitively normal older adults Open
Background The ability to accurately discern memory function (i.e., metamemory) decreases with age and is further diminished in Alzheimer’s disease (AD). As such, changes in metamemory may be a sensitive behavioral indicator of pre‐symptom…
View article: Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces
Neuroinflammation at the Gray–White Matter Interface in Active-Duty U.S. Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the gray-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no in…
View article: Speech motor impairment in ALS is associated with multiregional cortical thinning beyond primary motor cortex
Speech motor impairment in ALS is associated with multiregional cortical thinning beyond primary motor cortex Open
Introduction Cortical thinning is well-documented in individuals with amyotrophic lateral sclerosis (ALS), yet its association with speech deterioration remains understudied. This study characterizes anatomical changes in the brain within …
View article: Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study
Toward AI-driven neuroepigenetic imaging biomarker for alcohol use disorder: A proof-of-concept study Open
Alcohol use disorder (AUD) is a disorder of clinical and public health significance requiring novel and improved therapeutic solutions. Both environmental and genetic factors play a significant role in its pathophysiology. However, the und…
View article: Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces
Neural Network Correlates of Apathy, Disinhibition, and Executive Dysfunction in Active-Duty United States Special Operations Forces Open
United States Special Operations Forces (SOF) experience neurobehavioral symptoms that can adversely affect training and combat operations. Understanding the neurobiological basis for these symptoms may guide prevention and treatment. In 2…
View article: Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces
Neuroinflammation at the Grey-White Matter Interface in Active-Duty United States Special Operations Forces Open
Emerging evidence from autopsy studies indicates that interface astroglial scarring (IAS) at the grey-white matter junction is a pathological signature of repeated blast brain injury in military personnel. However, there is currently no ne…
View article: A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging
A Fast-Binding, Functionally Reversible, COX-2 Radiotracer for CNS PET Imaging Open
Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous system (CNS), COX-2 is implicated in neurodegenerative and psychiatric disorders as a…
View article: Impact of repeated blast exposure on active-duty United States Special Operations Forces
Impact of repeated blast exposure on active-duty United States Special Operations Forces Open
United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is n…
View article: Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia Open
Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN are one of the most common genetic causes of FTD, near ubiquitously resulting in p…
View article: In vivo translocator protein in females with autism spectrum disorder: a pilot study
In vivo translocator protein in females with autism spectrum disorder: a pilot study Open
Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio of approximately 4:1. The clinical presentation of the core symptoms of ASD can also vary between sexes. Previously,…
View article: Characterization of cortico-meningeal translocator protein expression in multiple sclerosis
Characterization of cortico-meningeal translocator protein expression in multiple sclerosis Open
Compartmentalized meningeal inflammation is thought to represent one of the key players in the pathogenesis of cortical demyelination in multiple sclerosis. PET targeting the 18 kDa mitochondrial translocator protein (TSPO) is a molecular-…