Explanipedia

Concurrent Atopic Dermatitis and Psoriasis Vulgaris: Implications for Targeted Biologic Therapy Open

J R Johnson · 2022

Psoriasis vulgaris, a helper T cell T_H1/T_H17-mediated inflammatory dermatosis, may be effectively treated with biologic medications such as secukinumab, an IL-17A inhibitor. However, suppression of the T_H1-…

Bill for an act relating to the hospital established by chapter 174 of the session laws of 1921 Open

J R Johnson, Niven · 2022

Can Atopic Dermatitis and Allergic Contact Dermatitis Coexist? Open

J R Johnson · 2021

Due to their seemingly divergent immune pathways, it previously was thought that atopic dermatitis (AD) and allergic contact dermatitis (ACD) could not occur together. However, novel research suggests that the 2 conditions may be more clos…

European Congress on Obesity (ECO Online 2021). 28th Congress, 10-13 May, 2021. LATE BREAKING ABSTRACTS Open

Kotze Horstmann, Ayele, Bedada, J R Johnson, Mabasa , et al. · 2021

Introduction: Globally, obesity places an enormous burden on health care systems due to related co-morbidities such as diabetes and cardiovascular disease.Current pharmaceutical treatments addressing obesity are plagued by low efficacy and…

Editorial Note on Drug Availability Open

J R Johnson · 2021

Drug delivery through the oral mucous film is considered to be a promising contrasting option to the oral course. Sublingual course is a quick onset of activity and preferred patient consistence over orally ingested tablets. Sublingual (…

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 Open

Vos, Allen, Arora, Barber, Brown , et al. · 2020

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological trans ...

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Open

Anthony Anthony, Gilardi, Menachery, Goldstein, Ssebide , et al. · 2020

The evolutionary origins of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) are unknown. Current evidence suggests that insectivorous bats are likely to be the original source, as several 2c CoVs have been described from var…

Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4 Open

Arbones-Mainar, J R Johnson, Torres-Perez, García, Perez-Diaz , et al. · 2020

The Apolipoprotein E (APOE) gene encodes for three isoforms in the human population (APOE2, APOE3, and APOE4). While the role of APOE in lipid metabolism is well characterized, the specific metabolic signatures of the APOE isoforms, during…

Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort Open

Tracy A. Manuck, Madeline Murguia Rice, Jennifer L. Bailit, William A. Grobman, Uma M. Reddy , et al. · 2020

Although preterm birth less than 37 weeks gestation is the leading cause of neonatal morbidity and mortality in the United States, the majority of data regarding preterm neonatal outcomes come from older studies, and many reports have been…

Defining failed induction of labor Open

William A. Grobman, Jennifer L. Bailit, Yinglei Lai, Uma M. Reddy, Ronald J. Wapner , et al. · 2020

BACKGROUND: While there are well-accepted standards for the diagnosis of arrested active-phase labor, the definition of a "failed" induction of labor remains less certain. One approach to diagnosing a failed induction is based on the durat…

Vitamin D receptor polymorphisms and survival in patients with cutaneous melanoma: a population-based study Open

Irene Orlow, Anne S. Reiner, Nancy E. Thomas, Pampa Roy, Peter A. Kanetsky , et al. · 2020

Factors known to affect melanoma survival include age at presentation, sex and tumor characteristics. Polymorphisms also appear to modulate survival following diagnosis. Result from other studies suggest that vitamin D receptor (VDR) polym…

The Influence of Direct Versus Indirect Observation, Candidate Report Format, and Assessor Training on the Accuracy of Assessor Ratings Open

J R Johnson, Lukas Rudolph · 2019

Within the assessment center method, assessors' preliminary evaluations of candidates' performance are typically based on information obtained through direct observation of the candidate's performance in the situational exercise, or on ano…

Trans-Neptunian objects found in the first four years of the Dark Energy Survey Open

P. H. Bernardinelli, GM Bernstein, M. Šako, T Liu, WR Saunders , et al. · 2019

We present a catalog of 316 trans-Neptunian bodies detected by the Dark Energy Survey (DES). These objects include 245 discoveries by DES (139 not previously published) detected in $\approx 60,000$ exposures from the first four seasons of …

Persuasion through other-orientedness: an exploration in empathic influence tactics Open

J R Johnson · 2018

Qualities that make a person persuasive have been well-studied in the persuasion literature, typically considering such qualities as credibility, expertise, attractiveness, similarity, or likeability (Briñol & Petty, 2006; Chaikan, 1980; M…

ISOLATION AND PURIFICATION OF A FIBRINOLYTIC ENZYME FROM BACTERIAL STRAIN ISOLATED FROM TUAK, AN INDONESIAN PALM WINE Open

J R Johnson, Yanti Yanti, Maggy Thenawidjaja Suhartono · 2017

Palm wine, known as tuak in Indonesia, is a traditional alcoholic beverage in Tapanuli region, North Sumatera that is made by fermenting the sugary sap of sugar palm tree (Arenga pinnata) and the bark of tree called raru (Vatica pauciflora…

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