Adrian Edwards
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View article: Critical illness in prisons: a multi-method analysis of reported healthcare safety incidents in England
Critical illness in prisons: a multi-method analysis of reported healthcare safety incidents in England Open
Prisoners have disproportionately poorer health and complex needs compared to the general population. Prisons should provide care that is equivalent to community care to achieve equitable health outcomes, which includes managing physical d…
View article: Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis
Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis Open
Introduction Patients with cancer are at increased risk of thrombotic complications from both the disease and its treatments, with antithrombotic therapy (ATT) usually continued in the last phase of life where the benefit is less clear and…
View article: Cost‐Effectiveness of a Personalised Self‐Management Intervention for People Living With Long Covid: The LISTEN Randomised Controlled Trial
Cost‐Effectiveness of a Personalised Self‐Management Intervention for People Living With Long Covid: The LISTEN Randomised Controlled Trial Open
Background In the United Kingdom, at least 1.9 million people are estimated to have experienced long Covid, of which 1.3 million have symptoms lasting for more than a year. The Long CovId Personalised Self‐managemenT support EvaluatioN (LI…
View article: Detection of serum HER2 in patients treated with neratinib or trastuzumab: analysis of the I-SPY Trial
Detection of serum HER2 in patients treated with neratinib or trastuzumab: analysis of the I-SPY Trial Open
Purpose Drugs targeting human epidermal growth factor receptor 2 (HER2) have fundamentally changed the way breast cancer is treated. Measurement of HER2 expression has become increasingly important with the approval of therapies targeting …
View article: Public awareness of care pathways and available skill mix in NHS dental teams: a qualitative study
Public awareness of care pathways and available skill mix in NHS dental teams: a qualitative study Open
Introduction Limited public understanding of the dental team's roles and confusion about accessing urgent dental care (UDC) and emergency dental services (EDSs) are barriers to efficient service use. Understanding and addressing these gaps…
View article: “Who am I to say that I'm not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer
“Who am I to say that I'm not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer Open
Sixty patients and 13 relatives participated. Three major themes were generated: CONCLUSION: Patients found decision-making around ATT near the end of life multifaceted, occurring amid a myriad of competing priorities. While patients repor…
View article: Integrated care for older people or people living with frailty and waiting times/lists – a mixed methods rapid review
Integrated care for older people or people living with frailty and waiting times/lists – a mixed methods rapid review Open
Integrated care can be defined as the joining up of different health and/or social services to deliver care that meets individuals’ needs in an efficient way. There is limited clarity about the effectiveness of integrated care intervention…
View article: Quality of vitamin K antagonist treatment during the last year of life
Quality of vitamin K antagonist treatment during the last year of life Open
Limited data exist on the quality of anticoagulation in patients approaching the end of life. This study evaluated vitamin K antagonist (VKA) anticoagulation control during the last year of life, using nationwide data from Statistics Nethe…
View article: A rapid review of interventions to reduce suicide ideation, attempts, and deaths at public locations
A rapid review of interventions to reduce suicide ideation, attempts, and deaths at public locations Open
Suicide deaths are tragic events and those that occur in public places have an impact not only on the deceased person and their family and friends, but also on members of the public. Having up-to-date information about the effectiveness of…
View article: Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease
Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease Open
Data on risks and benefits of long-term anticoagulants in patients with a life-limiting disease are limited. This cohort study aims to describe (dis)continuation of anticoagulants and incidences of bleeding and thromboembolic events in vit…
View article: Involving patients and the public in cancer associated thrombosis research: A strategy for success
Involving patients and the public in cancer associated thrombosis research: A strategy for success Open
The role of public involvement (PI) in biomedical research has never been greater, with accumulating evidence demonstrating its ability to improve the quality of research and the likelihood of translating findings into clinical practice. A…
View article: Knowledge mobilisation of rapid evidence reviews to inform health and social care policy and practice in a public health emergency: Appraisal of the Wales COVID-19 Evidence Centre processes and impact, 2021–23
Knowledge mobilisation of rapid evidence reviews to inform health and social care policy and practice in a public health emergency: Appraisal of the Wales COVID-19 Evidence Centre processes and impact, 2021–23 Open
Background The Wales COVID-19 Evidence Centre (WCEC) was established from 2021–23 to ensure that the latest coronavirus (COVID-19) relevant research evidence was readily available to inform health and social care policy and practice decisi…
View article: Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer
Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer Open
Our study describes medical decision-making regarding ATT in EOLC of patients with cancer. Healthcare professionals' perspectives and practice patterns vary, and some preferences appear associated with the therapists' professional focus an…
View article: What is the most effective method of delivering Making Every Contact Count training? A rapid review
What is the most effective method of delivering Making Every Contact Count training? A rapid review Open
The Making Every Contact Count MECC programme encourages staff to have opportunistic brief behaviour change conversations with service users. It uses the day-to-day interactions that healthcare professionals, or those within other organisa…
View article: Factors associated with overweight or obesity in children under five years old: a rapid review
Factors associated with overweight or obesity in children under five years old: a rapid review Open
Over one-quarter of children in Wales aged four-to-five live with overweight or obesity. Children with overweight or obesity may experience health issues during childhood or adolescence, or both. They are also more likely to have overweigh…
View article: Transient Ischaemic attack Emergency Referral (TIER): randomised feasibility trial results
Transient Ischaemic attack Emergency Referral (TIER): randomised feasibility trial results Open
Background Early assessment of patients with suspected transient ischaemic attack (TIA) is crucial to provision of effective care, including initiation of preventive therapies and identification of stroke mimics. Many patients with TIA pre…
View article: Rapid review of Allied Health Professionals working in neonatal services
Rapid review of Allied Health Professionals working in neonatal services Open
Background This review aimed to quantify the impact of allied health professionals (AHPs) embedded in neonatal services on outcomes by asking the following review questions: Q1. What is the effectiveness of neonatal services with embedded …
View article: A rapid review of the effectiveness of smoking cessation interventions for people with anxiety and/or depression living within the community
A rapid review of the effectiveness of smoking cessation interventions for people with anxiety and/or depression living within the community Open
The Welsh Government aims to reduce smoking prevalence from the current rate of 13% to below 5% of the population by 2030. People with mental health conditions have a higher rate of smoking prevalence and are less likely to access smoking …
View article: Recurrent urinary tract infections and prophylactic antibiotic use in women: a cross-sectional study in primary care
Recurrent urinary tract infections and prophylactic antibiotic use in women: a cross-sectional study in primary care Open
Background Despite the considerable morbidity caused by recurrent urinary tract infections (rUTIs), and the wider personal and public health implications from frequent antibiotic use, few studies adequately describe the prevalence and char…
View article: A rapid review of the effectiveness of interventions to enhance equitable or overall access to mental health services by ethnic minority groups
A rapid review of the effectiveness of interventions to enhance equitable or overall access to mental health services by ethnic minority groups Open
It is estimated that one in four people will experience poor mental health throughout their lifetime. However, ethnic minority groups, refugees and asylum seekers experience more barriers accessing mental health services and have poorer me…
View article: An experimental study of an animal-assisted intervention in healthcare simulation to reduce negative affective arousal post-simulation
An experimental study of an animal-assisted intervention in healthcare simulation to reduce negative affective arousal post-simulation Open
Introduction In healthcare simulation, the appropriate level of stress produced through physiological and psychological arousal is necessary for effective experiential learning. While beneficial stress promotes learning, excessive stress i…
View article: Programme theories to describe how different general practitioner service models work in different contexts in or alongside emergency departments (GP-ED): realist evaluation
Programme theories to describe how different general practitioner service models work in different contexts in or alongside emergency departments (GP-ED): realist evaluation Open
Background Addressing increasing patient demand and improving ED patient flow is a key ambition for NHS England. Delivering general practitioner (GP) services in or alongside EDs (GP-ED) was advocated in 2017 for this reason, supported by …
View article: Evaluation of different models of general practitioners working in or alongside emergency departments: a mixed-methods realist evaluation
Evaluation of different models of general practitioners working in or alongside emergency departments: a mixed-methods realist evaluation Open
Background Emergency healthcare services are under intense pressure to meet increasing patient demands. Many patients presenting to emergency departments could be managed by general practitioners in general practitioner–emergency departmen…
View article: A rapid review of the effectiveness of interventions for addressing digital exclusion in older adults
A rapid review of the effectiveness of interventions for addressing digital exclusion in older adults Open
Older adults constitute the largest proportion of non-users of the internet. With the increasing digitalisation of services, in particular those provided in Social Care in Wales, it is important to understand how best to support older adul…