Matthew Koshy
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View article: Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells.
Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells. Open
Haploidentical Hematopoietic stem cell transplantation (haplo-HSCT) remains the only curative option for adults with advanced sickle cell disease (SCD) without an HLA-matched sibling donor or access to gene therapy. We analyzed long-term o…
View article: Stereotactic Body Radiation Therapy Facilitating Debulking Surgery in Metastatic VIPoma with Severe Diarrhea and Hypovolemic Shock
Stereotactic Body Radiation Therapy Facilitating Debulking Surgery in Metastatic VIPoma with Severe Diarrhea and Hypovolemic Shock Open
BACKGROUND Treatment of metastatic vasoactive intestinal peptide tumors (VIPoma) is challenging and requires a careful multidisciplinary approach to achieve optimal disease control. We present a case of metastatic VIPoma with recurring epi…
View article: Intensified conditioning with high-dose total marrow irradiation and myeloablative chemotherapy reduces risk of relapse without increasing toxicity in allogeneic hematopoietic stem cell transplant for high-risk myeloid malignancies: a phase II study
Intensified conditioning with high-dose total marrow irradiation and myeloablative chemotherapy reduces risk of relapse without increasing toxicity in allogeneic hematopoietic stem cell transplant for high-risk myeloid malignancies: a phase II study Open
The intensity of the conditioning regimen in hematopoietic stem cell transplantation (HSCT) correlates with the risk of relapse, however its potential benefit may be outweighed by the associated risk of toxicity. The addition of total marr…
View article: Limited survival benefit in patients diagnosed with glioblastoma post-2016: a SEER population based registry analysis
Limited survival benefit in patients diagnosed with glioblastoma post-2016: a SEER population based registry analysis Open
This population-based cohort demonstrated minimal change in survival for patients diagnosed with GBM before and after FDA approval of TTFs in 2015.
View article: Global blood and marrow transplantation training for international physicians from LMICs: 5-year experience at UIC
Global blood and marrow transplantation training for international physicians from LMICs: 5-year experience at UIC Open
View article: The Patterns of Failure and Prognostic Impact of Tumor Location in Patients Undergoing Reirradiation for Glioblastoma
The Patterns of Failure and Prognostic Impact of Tumor Location in Patients Undergoing Reirradiation for Glioblastoma Open
Introduction RTOG 1205 is the only randomized study to evaluate the safety and efficacy of reirradiation (reRT) in recurrent glioblastoma (GBM). While this study showed that reRT was safe and improves progression-free survival (PFS), an im…
View article: SBRT for Liver Tumors: What the Interventional Radiologist Needs to Know
SBRT for Liver Tumors: What the Interventional Radiologist Needs to Know Open
This review summarizes the clinical evidence supporting the utilization of stereotactic body radiotherapy (SBRT) for liver tumors, including hepatocellular carcinoma, liver metastases, and cholangiocarcinoma. Emerging prospective evidence …
View article: The importance of considering competing risks in recurrence analysis of intracranial meningioma
The importance of considering competing risks in recurrence analysis of intracranial meningioma Open
View article: EP04.02-01 Impact of an Urban Based Lung Cancer Screening Program: Seven Year Follow-up
EP04.02-01 Impact of an Urban Based Lung Cancer Screening Program: Seven Year Follow-up Open
View article: P1.22-01 Clinical Characteristics and Biomarkers in Lung Cancer: A Comparison Between Screened and Non-Screened Cohorts
P1.22-01 Clinical Characteristics and Biomarkers in Lung Cancer: A Comparison Between Screened and Non-Screened Cohorts Open
View article: Data from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis
Data from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis Open
Background: Cancer-specific mortality (CSM) is known to be higher among blacks and lower among Hispanics compared with whites. Private insurance confers CSM benefit, but few studies have examined the relationship between insurance s…
View article: Supplementary Table 1 from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis
Supplementary Table 1 from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis Open
Multivariate Cox model for cancer-specific mortality with race-insurance interaction term
View article: Supplementary Table 1 from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis
Supplementary Table 1 from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis Open
Multivariate Cox model for cancer-specific mortality with race-insurance interaction term
View article: Data from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis
Data from Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis Open
Background: Cancer-specific mortality (CSM) is known to be higher among blacks and lower among Hispanics compared with whites. Private insurance confers CSM benefit, but few studies have examined the relationship between insurance s…
View article: Knowledge-based planning for multi-isocenter VMAT total marrow irradiation
Knowledge-based planning for multi-isocenter VMAT total marrow irradiation Open
Purpose Total marrow irradiation (TMI) involves optimization of extremely large target volumes and requires extensive clinical experience and time for both treatment planning and delivery. Although volumetric modulated arc therapy (VMAT) a…
View article: Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma
Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma Open
Optimized, risk-stratified surveillance regimens consistently outperformed nonoptimized strategies. These gains were obtained without requiring any additional imaging studies. This approach to risk-stratified surveillance optimization is g…
View article: Decreased overall survival in patients with locally advanced head and neck cancer receiving definitive radiotherapy and concurrent cetuximab: National Cancer Database analysis
Decreased overall survival in patients with locally advanced head and neck cancer receiving definitive radiotherapy and concurrent cetuximab: National Cancer Database analysis Open
Background Recently, randomized trials have questioned the efficacy of cetuximab‐based bioradiotherapy compared to chemoradiation for patients with squamous cell carcinoma of the oropharynx, larynx, and hypopharynx (HNSCC). We compared the…
View article: An Analysis of Patient Characteristics and Clinical Outcomes in Primary Pulmonary Sarcoma
An Analysis of Patient Characteristics and Clinical Outcomes in Primary Pulmonary Sarcoma Open
INTRODUCTION: Literature concerning primary pulmonary sarcomas (PPS) is limited to small case series. This study examines, in a large cohort, the clinical characteristics and therapeutic strategies of PPS and their impact on overall surviv…
View article: Impact of anatomic site of distant metastasis on survival in salivary gland cancers
Impact of anatomic site of distant metastasis on survival in salivary gland cancers Open
Background As exemplified in patients with adenoid cystic carcinoma (ACC), metastatic salivary gland cancers display heterogenous behavior. Although anatomic site of metastasis has been suggested to be prognostic for survival in this popul…
View article: Brief Report: Risk Prediction Model Versus United States Preventive Services Task Force 2020 Draft Lung Cancer Screening Eligibility Criteria—Reducing Race Disparities
Brief Report: Risk Prediction Model Versus United States Preventive Services Task Force 2020 Draft Lung Cancer Screening Eligibility Criteria—Reducing Race Disparities Open
View article: Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer Open
These findings suggest that machine learning models may identify patients with intermediate risk who could benefit from chemoradiation. These models predicted that approximately half of such patients have no added benefit from chemotherapy.
View article: Clinical Outcomes for Gastric Cancer following Adjuvant Chemoradiation Utilizing Intensity Modulated versus Three-Dimensional Conformal Radiotherapy
Clinical Outcomes for Gastric Cancer following Adjuvant Chemoradiation Utilizing Intensity Modulated versus Three-Dimensional Conformal Radiotherapy Open
Purpose/Objective(s)To determine if intensity modulated radiation therapy (IMRT) in the post-operative setting for gastric cancer was associated with reduced toxicity compared to 3D conformal radiation therapy (3DCRT).Materials/MethodsThis…
View article: Patterns of Care and Survival Outcomes for Odontogenic Cancers
Patterns of Care and Survival Outcomes for Odontogenic Cancers Open
Objectives Our understanding of odontogenic cancers is limited primarily to case studies given the rarity of these head and neck neoplasms. Using the National Cancer Database, we report the treatment patterns and survival outcomes for one …
View article: Patterns Of Care And Survival Outcomes Of Squamous Cell Carcinoma Of The Orbit: A National Cancer Database Analysis
Patterns Of Care And Survival Outcomes Of Squamous Cell Carcinoma Of The Orbit: A National Cancer Database Analysis Open
View article: Knowledge-Based VMAT Planning of Total Marrow Irradiation as a Part of Conditioning Regimen Before Allo-SCT in a Prospective Phase I/II Study
Knowledge-Based VMAT Planning of Total Marrow Irradiation as a Part of Conditioning Regimen Before Allo-SCT in a Prospective Phase I/II Study Open
View article: Local Recurrence Following Total Marrow Radiation: Implications for Clinical Target Delineation
Local Recurrence Following Total Marrow Radiation: Implications for Clinical Target Delineation Open
Total marrow radiation is an emerging treatment modality used in patients undergoing stem cell transplantation. We present a rare case of a patient undergoing total marrow irradiation with concurrent ablative stem cell transplantation with…
View article: Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis
Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis Open
Early stage glottic cancer has traditionally been treated with 3D conformal radiotherapy (3DCRT). However, intensity-modulated radiotherapy (IMRT) has been recently adopted as an alternative to decrease toxicity. Here, we compared the usag…
View article: Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis
Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis Open
Background Immunosuppressive regimens associated with organ transplantation increase the risk of developing cancer. Transplant candidates and recipients with prostate cancer are often treated, even if low-risk features would ordinarily jus…
View article: P1.11-06 Expanding Criteria for Lung Cancer Screening Reduces Gender Disparity
P1.11-06 Expanding Criteria for Lung Cancer Screening Reduces Gender Disparity Open
View article: Prospective Evaluation of Total Body Radiation in the Conditioning Regimen of Patients Undergoing Allogeneic Stem Cell Transplantation for Sickle Cell Disease
Prospective Evaluation of Total Body Radiation in the Conditioning Regimen of Patients Undergoing Allogeneic Stem Cell Transplantation for Sickle Cell Disease Open