Matthew L. Arwood
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View article: Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively
Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively Open
Background/Objectives: Metabolic enzymes are crucial for the detoxification of exogenously administered drugs, especially enzymes expressed in the intestine and the liver. Recent advancements in analytical methodologies enable sensitive an…
View article: Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism
Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism Open
In order to study mechanistic/mammalian target of rapamycin’s role in T cell differentiation, we generated mice in which Rheb is selectively deleted in T cells (T-Rheb−/− C57BL/6J background). During these studies, we noted that T-Rheb−/− …
View article: New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation Open
View article: Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug Open
6-Diazo-5-oxo- l -norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON showed promising efficacy in clinical trials; however, its deve…
View article: Persistent CAD activity in memory CD8 <sup>+</sup> T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Persistent CAD activity in memory CD8 <sup>+</sup> T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge Open
Memory CD8 + T cells are characterized by their ability to persist long after the initial antigen encounter and their capacity to generate a rapid recall response. Recent studies have identified a role for metabolic reprogramming and mitoc…
View article: Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge Open
Memory CD8+ T cells are characterized by their ability to persist long after the initial antigen encounter and their ability to generate a rapid recall response. Recent studies have identified a role for metabolic reprogramming and mitocho…
View article: Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells Open
Myeloid cells comprise a major component of the tumor microenvironment (TME) that promotes tumor growth and immune evasion. By employing a small-molecule inhibitor of glutamine metabolism, not only were we able to inhibit tumor growth, but…
View article: Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages
Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation of MDSCs and reprogramming tumor associated macrophages Open
Summary Myeloid cells comprise a major component of the Tumor Microenvironment (TME) promoting tumor growth and immune evasion. By employing a novel small molecule inhibitor of glutamine metabolism not only were we able to inhibit tumor gr…
View article: mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages
mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages Open
View article: mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation Open
CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of prote…