Matthew L. Baker
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View article: Supplementary Table 1 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Table 1 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
List of antibodies and reagents used in the study.
View article: Supplementary Figure 2 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 2 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
ENG CAR design and molecular modeling.
View article: Supplementary Figure 3 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 3 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
Activation induced cytokine release and proliferation of ENG CAR-T.
View article: Supplementary Figure 5 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 5 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
Efficacy of ENG CAR-T in orthotopic xenograft models of sarcoma.
View article: Supplementary Figure 6 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 6 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
The c-SN6j/TRC105 antibody does not recognize murine or rhesus endoglin.
View article: Supplementary Figure 4 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 4 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
Binding of recombinant ENG to CAR-T.
View article: Data from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Data from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
There are limited therapeutic options for patients with advanced sarcomas, which leads to dismal outcomes for children and adults. Although chimeric antigen receptor (CAR) T cells hold promise for treating advanced sarcomas, this approach …
View article: Supplementary Table 2 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Table 2 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
Rhabdomyosarcoma cell lines with transcript expression of ENG, CD44, CD70, and CD90 from the CCLE public release 24Q4 with fusion status and histology.
View article: Supplementary Figure 1 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas
Supplementary Figure 1 from Endoglin-Directed CAR T Cells Comprehensively Target Tumors in Advanced Sarcomas Open
ENG expression in sarcoma tissues and cell lines.
View article: DNA deformability defines sequence-dependent capture of E. coli gyrase
DNA deformability defines sequence-dependent capture of E. coli gyrase Open
View article: The microbiome-restorative potential of ibezapolstat for the treatment of <i>Clostridioides difficile</i> infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae
The microbiome-restorative potential of ibezapolstat for the treatment of <i>Clostridioides difficile</i> infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae Open
Ibezapolstat (IBZ), a first-in-class antibiotic targeting the PolC-type DNA polymerase III alpha-subunit (PolC) in low G + C bacteria, is in clinical development for the treatment of Clostridioides difficile infection (CDI). In the phase 2…
View article: Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge Open
The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein-nucleic acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic…
View article: Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge
Outcomes of the EMDataResource Cryo-EM Ligand Modeling Challenge Open
View article: Predictive modeling and cryo-EM: A synergistic approach to modeling macromolecular structure
Predictive modeling and cryo-EM: A synergistic approach to modeling macromolecular structure Open
View article: Architecture of the baculovirus nucleocapsid revealed by cryo-EM
Architecture of the baculovirus nucleocapsid revealed by cryo-EM Open
View article: Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex
Structural insights into cardiolipin replacement by phosphatidylglycerol in a cardiolipin-lacking yeast respiratory supercomplex Open
View article: The structure of a 12-segmented dsRNA reovirus: New insights into capsid stabilization and organization
The structure of a 12-segmented dsRNA reovirus: New insights into capsid stabilization and organization Open
Infecting a wide range of hosts, members of Reovirales (formerly Reoviridae) consist of a genome with different numbers of segmented double stranded RNAs (dsRNA) encapsulated by a proteinaceous shell and carry out genome replication and tr…
View article: Figure S4 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
Figure S4 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer Open
L2 CAR T cells provide a survival advantage and disrupt vessels and tumor architecture in TNBC xenografts .
View article: Figure S5 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
Figure S5 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer Open
No overt toxicity detected in mice receiving TEM8 CAR T cells.
View article: Figure S5 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
Figure S5 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer Open
No overt toxicity detected in mice receiving TEM8 CAR T cells.
View article: Figure S2 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer
Figure S2 from TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer Open
L2 CAR T cells reduce mammosphere formation when compared to irrelevant CAR control cells.
View article: Conformational motions and ligand-binding underlying gating and regulation in IP3R channel
Conformational motions and ligand-binding underlying gating and regulation in IP3R channel Open
Inositol-1,4,5-trisphosphate receptors (IP 3 Rs) are activated by IP 3 and Ca 2+ and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we deter…
View article: Structural insights into cardiolipin stabilization of yeast respiratory supercomplexes revealed by Cryo-EM
Structural insights into cardiolipin stabilization of yeast respiratory supercomplexes revealed by Cryo-EM Open
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still …
View article: Structural insights into cardiolipin stabilization of yeast respiratory supercomplexes revealed byCryo-EM
Structural insights into cardiolipin stabilization of yeast respiratory supercomplexes revealed byCryo-EM Open
Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still …
View article: Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies
Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies Open
CD19-targeted immunotherapies that stimulate a cytotoxic T-cell response have revolutionized the management of B-cell malignancies, specifically relapsed or refractory acute lymphoblastic leukemia (R/ R ALL).Blinatumomab is an anti-CD19 bi…
View article: Beyond the Backbone: The Next Generation of Pathwalking Utilities for Model Building in CryoEM Density Maps
Beyond the Backbone: The Next Generation of Pathwalking Utilities for Model Building in CryoEM Density Maps Open
Single-particle electron cryomicroscopy (cryoEM) has become an indispensable tool for studying structure and function in macromolecular assemblies. As an integral part of the cryoEM structure determination process, computational tools have…
View article: AlphaFold2 and CryoEM: Revisiting CryoEM modeling in near-atomic resolution density maps
AlphaFold2 and CryoEM: Revisiting CryoEM modeling in near-atomic resolution density maps Open
View article: Structural dynamics underlying gating and regulation in IP<sub>3</sub>R channel
Structural dynamics underlying gating and regulation in IP<sub>3</sub>R channel Open
Inositol-1,4,5-trisphosphate receptors (IP 3 Rs) are activated by IP 3 and Ca 2+ and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we deter…
View article: Author Correction: Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids
Author Correction: Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids Open
View article: Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids
Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids Open
Bacterial type IV secretion systems (T4SSs) are largely responsible for the proliferation of multi-drug resistance. We solved the structure of the outer-membrane core complex (OMCC F ) of a T4SS encoded by a conjugative F plasmid at <3.0 Å…