Matthew Leipzig
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View article: A Multi-Task Deep Learning Model for Pediatric Echocardiography Analysis
A Multi-Task Deep Learning Model for Pediatric Echocardiography Analysis Open
Background Congenital heart defects afflict nearly 1% of all births worldwide. While deep learning algorithms have shown significant promise in automating and improving adult echocardiography analysis, similar progress has not been observe…
View article: An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model
An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model Open
The axis-specific mitral annuloplasty ring we designed demonstrates excellent capability to repair mitral regurgitation while facilitating dynamic mitral annular motion. This ring has tremendous potential for clinical translatability, repr…
View article: Nonlinear effect of body mass index on postoperative survival following isolated heart transplantation
Nonlinear effect of body mass index on postoperative survival following isolated heart transplantation Open
After multivariable adjustment, there is no sharp cutoff in survival risk at either BMI = 30 or BMI = 35. Unlike previously reported, postoperative survival risk grows approximately linearly in the BMI range from 26 to 40.
View article: Type A intramural hematoma over 21 years: A single center's experience
Type A intramural hematoma over 21 years: A single center's experience Open
In conclusion, a surgical management strategy for acute TAIMH results in excellent postoperative outcomes and supports an aggressive emergent operative strategy in aortic centers of excellence.
View article: A Generalizable Deep Learning System for Cardiac MRI
A Generalizable Deep Learning System for Cardiac MRI Open
Cardiac MRI allows for a comprehensive assessment of myocardial structure, function, and tissue characteristics. Here we describe a foundational vision system for cardiac MRI, capable of representing the breadth of human cardiovascular dis…
View article: Does delaying surgery following induction chemotherapy compromise survival in patients with mesothelioma?
Does delaying surgery following induction chemotherapy compromise survival in patients with mesothelioma? Open
Objective: The ideal time interval between induction chemotherapy and surgery and the impact on cancer mortality in patients with mesothelioma remains unclear. Methods: We queried the National Cancer Database (2004-2017) for patients with …
View article: Lineage-Specific Induced Pluripotent Stem Cell–Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice
Lineage-Specific Induced Pluripotent Stem Cell–Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice Open
Background: The role of increased smooth muscle cell (SMC) integrin αv signaling in Marfan syndrome (MFS) aortic aneurysm remains unclear. Herein, we examine the mechanism and potential efficacy of integrin αv blockade as a therapeutic str…
View article: Combined Heart-Lung Transplantation Outcomes in Asian Populations
Combined Heart-Lung Transplantation Outcomes in Asian Populations Open
This large-scale analysis in Asian patients will have important implications in Asian countries that have relatively fewer HLTx surgeries. An outcome equivalent to NHW in Asian patients, as demonstrated in our study, could be the driving f…
View article: Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator
Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator Open
OBJECTIVES The severity of acute papillary muscle (PM) rupture varies according to the extent and site of the rupture. However, the haemodynamic effects of different rupture variations are still poorly understood. Using a novel ex vivo mod…
View article: Effect of Oxygen Extraction (Brush: Sign) on Baseline Core Infarct Depends on Collaterals (HIR)
Effect of Oxygen Extraction (Brush: Sign) on Baseline Core Infarct Depends on Collaterals (HIR) Open
Background: Baseline-core-infarct volume is a critical factor in patient selection and outcome in acute ischemic stroke (AIS) before mechanical thrombectomy (MT). We determined whether oxygen extraction efficiency and arterial collaterals,…
View article: Biomechanical engineering analysis of commonly utilized mitral neochordae
Biomechanical engineering analysis of commonly utilized mitral neochordae Open
Under experimental conditions, the running neochord technique has the best mechanical performance due to an increased rupture force. If using running neochordae, more than 1 independent set of multiple running neochordae are advised (ie, >…
View article: Impact of Clot Shape on Successful M1 Endovascular Reperfusion
Impact of Clot Shape on Successful M1 Endovascular Reperfusion Open
Objectives: The susceptibility-vessel-sign (SVS) allows thrombus visualization, length estimation and composition, and it may impact reperfusion during mechanical thrombectomy (MT). SVS can also describe thrombus shape in the occluded arte…
View article: Effect of Oxygen Extraction (Brush-Sign) on Baseline Core Infarct Depends on Collaterals (HIR)
Effect of Oxygen Extraction (Brush-Sign) on Baseline Core Infarct Depends on Collaterals (HIR) Open
Objectives: Baseline-core-infarct volume is a critical factor in patient selection and outcome in acute ischemic stroke (AIS) before mechanical thrombectomy (MT). We determined whether oxygen extraction efficiency and arterial collaterals,…