Explanipedia

A human monoclonal autoantibody to breast cancer identifies the PDZ domain containing protein GIPC1 as a novel breast cancer-associated antigen Open

Sergei Rudchenko, Matthew J. Scanlan, Gavreel Kalantarov, Victoria Yavelsky, Chen Levy , et al. · 2008

Background We have been studying the native autoimmune response to cancer through the isolation of human monoclonal antibodies that are cancer specific from cancer patients. To facilitate this work we previously developed a fusion partner …

Frequent and specific immunity to the embryonal stem cell–associated antigen SOX2 in patients with monoclonal gammopathy Open

Radek Špíšek, Anjli Kukreja, Lin-Chi Chen, Phillip Matthews, Amitabha Mazumder , et al. · 2007

Specific targets of cellular immunity in human premalignancy are largely unknown. Monoclonal gammopathy of undetermined significance (MGUS) represents a precursor lesion to myeloma (MM). We show that antigenic targets of spontaneous immuni…

Multimarker RT–PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients Open

Aviram Nissan, Dirk Jäger, M Roystacher, Diana Prus, Tamar Peretz , et al. · 2006

The presence of metastases in lymph nodes is the most powerful prognostic factor in breast cancer patients. Routine histological examination of lymph nodes has limited sensitivity for the detection of breast cancer metastases. The aim of t…

Identification of cancer/testis-antigen genes by massively parallel signature sequencing Open

Yao‐Tseng Chen, Matthew J. Scanlan, Charis A. Venditti, Ramon Chua, Grégory Theiler , et al. · 2005

Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive …

An immunodominant SSX-2–derived epitope recognized by CD4+ T cells in association with HLA-DR Open

Maha Ayyoub, Charles S. Hesdorffer, Monica Montes, Andrea Merlo, Daniel E. Speiser , et al. · 2004

Ectopic gene expression in tumors versus normal somatic tissues provides opportunities for the specific immunotargeting of cancer cells. SSX gene products are expressed in tumors of different histological types and can be recognized by tum…

NY-ESO-1 Expression and Immunogenicity in Malignant and Benign Breast Tumors Open

Yurika Sugita, Hisashi Wada, Shoichiro Fujita, Tetsuya Nakata, Shuichiro Sato , et al. · 2004

NY-ESO-1 is a cancer/testis antigen expressed in normal adult tissues solely in the testicular germ cells of normal adults and in various cancers. It induces specific humoral and cellular immunity in patients with NY-ESO-1-expressing cance…

Human mena protein, a serex‐defined antigen overexpressed in breast cancer eliciting both humoral and CD8<sup>+</sup> T‐cell immune response Open

Francesca Di Modugno, Giovanna Bronzi, Matthew J. Scanlan, Duilia Del Bello, Simona Cascioli , et al. · 2004

Screening of a cDNA expression library from a primary breast tumor with the autologous patient serum led to the isolation of 6 cDNA clones corresponding to 3 different genes, including a novel gene that maps to chromosome 1 and encodes the…

Immunomic analysis of human sarcoma Open

Sang‐Yull Lee, Yuichi Obata, Masahiro Yoshida, Elisabeth Stockert, Barbara Williamson , et al. · 2003

The screening of cDNA expression libraries from human tumors with serum antibody (SEREX) has proven to be a powerful method for identifying the repertoire of tumor antigens recognized by the immune system of cancer patients, referred to as…

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor Open

Achim A. Jungbluth, Elisabeth Stockert, Hongyi Huang, V. Peter Collins, Keren Coplan , et al. · 2003

Epidermal growth factor receptor (EGFR) has attracted considerable attention as a target for cancer therapy. Wild-type (wt)EGFR is amplified/overexpressed in a number of tumor types, and several mutant forms of the coding gene have been fo…

Identification of cancer/testis genes by database mining and mRNA expression analysis Open

Matthew J. Scanlan, Claudia Gordon, Barbara Williamson, Sang‐Yull Lee, Yao‐Tseng Chen , et al. · 2002

Cancer/testis (CT) antigens are immunogenic proteins expressed predominantly in gametogenic tissue and cancer; they are considered promising target molecules for cancer vaccines. The identification of new CT genes is essential to the devel…

Challenges to the development of antigen-specific breast cancer vaccines Open

Matthew J. Scanlan, Dirk Jäger · 2001

Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer Open

Ali O. Güre, Elisabeth Stockert, Matthew J. Scanlan, Roger Keresztes, Dirk Jäger , et al. · 2000

Serological analysis of expression cDNA libraries (SEREX) derived from two small cell lung cancer (SCLC) cell lines using pooled sera of SCLC patients led to the isolation of 14 genes, including 4 SOX group B genes ( SOX1 , SOX2 , SOX3 , a…

Familial deficiency of the autoantigen PDZ-73 causes enteropathy and renal tubulopathy Open

Keith Lindley, Ben Glaser, Virpi V. Smith, Dianne Radley, Matthew J. Scanlan , et al. · 2000

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens Open

Elisabeth Stockert, Elke Jäger, Yao‐Tseng Chen, Matthew J. Scanlan, Ivan Gout , et al. · 1998

Evidence is growing for both humoral and cellular immune recognition of human tumor antigens. Antibodies with specificity for antigens initially recognized by cytotoxic T lymphocytes (CTLs), e.g., MAGE and tyrosinase, have been detected in…

Mouse fibroblast activation protein: Molecular cloning, alternative splicing and expression in the reactive stroma of epithelial cancers Open

Joachim Niedermeyer, Matthew J. Scanlan, Pilar Garin‐Chesa, Christine Daiber, Heinz H. Fiebig , et al. · 1997

The growth of solid neoplasms requires the recruitment of a supporting stroma. In most epithelial cancers, this stromal compartment comprises newly formed blood vessels and abundant, reactive stromal fibroblasts. Tumor stromal fibroblasts …

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening Open

Yao‐Tseng Chen, Matthew J. Scanlan, Uğur Şahin, Özlem Türeci, Ali O. Güre , et al. · 1997

Ser ological analysis of re combinant cDNA ex pression libraries (SEREX) using tumor mRNA and autologous patient serum provides a powerful approach to identify immunogenic tumor antigens. We have applied this methodology to a case of esoph…

Serological analysis of Melan-A(MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas. Open

Y T Chen, Elisabeth Stockert, Achim A. Jungbluth, Solam Tsang, Keren Coplan , et al. · 1996

Recent progress in the structural identification of human melanoma antigens recognized by autologous cytotoxic T cells has led to the recognition of a new melanocyte differentiation antigen, Melan-A(MART-1). To determine the properties of …

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Open

Matthew J. Scanlan, B.K. Mohan Raj, Benjamin F. Calvo, Pilar Garin‐Chesa, M P Sanz-Moncasi , et al. · 1994

The human fibroblast activation protein alpha (FAP alpha) is a M(r) 95,000 cell surface antigen selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone …

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