Matthew J. Weiss
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View article: Organ procurement organizations should develop policy regarding surrogate consent for normothermic regional perfusion
Organ procurement organizations should develop policy regarding surrogate consent for normothermic regional perfusion Open
Normothermic regional perfusion (NRP) is a postmortem technique that restores oxygenated blood flow to transplantable organs in situ after death determination in donation after circulatory death to improve organ viability and function. Alt…
View article: Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression
Regulatory T cells in liver metastases: emerging and divergent roles in tumour progression Open
Liver metastases (LMs) pose a significant burden of morbidity and mortality, resulting in a worse prognosis for many primary malignancies. Despite advancements in cancer treatment, such as immunotherapy, molecular therapies, additional lin…
View article: Esophageal reconstruction using a hypopharyngeal anastomosis – a single center experience with review of the literature
Esophageal reconstruction using a hypopharyngeal anastomosis – a single center experience with review of the literature Open
Background Lye ingestion or other esophageal trauma may require surgical reconstruction. The hypopharyngeal anastomosis during esophageal reconstruction is a technically demanding procedure with many nuances in approach. Patients often hav…
View article: Characteristics of “Very Early” Intrahepatic Cholangiocarcinoma Undergoing Liver Resection and Its Relationship With Carbohydrate Antigen 19‐9
Characteristics of “Very Early” Intrahepatic Cholangiocarcinoma Undergoing Liver Resection and Its Relationship With Carbohydrate Antigen 19‐9 Open
Introduction The concept of “very early” ICC ( ≤ 2 cm, single tumor) has been introduced in the context of LT. Due to the limited number of patients in this subset, the characteristics and long‐term outcomes have been ill‐defined. We sough…
View article: Sexual and gender minoritized persons in organ and tissue donation: a qualitative analysis
Sexual and gender minoritized persons in organ and tissue donation: a qualitative analysis Open
View article: Oncological Resectability Criteria for Intrahepatic Cholangiocarcinoma: A Preoperative Framework for Multidisciplinary Management
Oncological Resectability Criteria for Intrahepatic Cholangiocarcinoma: A Preoperative Framework for Multidisciplinary Management Open
View article: Preoperative Systemic Immune-Inflammatory Index Predicts Occult Nodal Disease in Clinically Node-Negative Intrahepatic Cholangiocarcinoma
Preoperative Systemic Immune-Inflammatory Index Predicts Occult Nodal Disease in Clinically Node-Negative Intrahepatic Cholangiocarcinoma Open
Background Accurate preoperative diagnosis of nodal status in intrahepatic cholangiocarcinoma (ICC) remains challenging. The objective of the current study was to determine if the systemic immune-inflammatory index (SII) was associated wit…
View article: Lived Experiences of Sexual and Gender Minorities in Solid Organ Transplantation: A Best-Fit Framework Synthesis and Inductive Thematic Analysis
Lived Experiences of Sexual and Gender Minorities in Solid Organ Transplantation: A Best-Fit Framework Synthesis and Inductive Thematic Analysis Open
Background: Organ and tissue donation and transplantation (OTDT) policies and practices lead to differential care for sexual and gender minorities (SGMs). The experiences of SGM patients and caregivers in the transplantation system have no…
View article: Recurrence-Free Survival as a Surrogate for Overall Survival Among Patients with Intrahepatic Cholangiocarcinoma Following Upfront Surgery: An International Multi-institutional Analysis
Recurrence-Free Survival as a Surrogate for Overall Survival Among Patients with Intrahepatic Cholangiocarcinoma Following Upfront Surgery: An International Multi-institutional Analysis Open
View article: The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma
The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma Open
Introduction While postoperative adjuvant chemotherapy (AC) is generally recommended for intrahepatic cholangiocarcinoma (ICC), its benefit remains debated. This study aimed to identify patients that may benefit from AC following liver res…
View article: Management of Peritoneal Metastasis in Patients with Pancreatic Ductal Adenocarcinoma
Management of Peritoneal Metastasis in Patients with Pancreatic Ductal Adenocarcinoma Open
The peritoneum is the second most common site of metastasis in patients with pancreatic ductal adenocarcinoma (PDAC). Up to half of all patients that undergo curative-intent resection eventually develop peritoneal metastasis (PM), which ac…
View article: A Composite Endpoint of Liver Surgery (CELS): Development and Validation of a Clinically Relevant Endpoint Requiring a Smaller Sample Size
A Composite Endpoint of Liver Surgery (CELS): Development and Validation of a Clinically Relevant Endpoint Requiring a Smaller Sample Size Open
Background The feasibility of trials in liver surgery using a single-component clinical endpoint is low because single endpoints require large samples due to their low incidence. The current study sought to develop and validate a novel com…
View article: Comparison of neoadjuvant chemotherapy plus radiation vs. chemotherapy alone on complete pathologic response in pancreatic adenocarcinoma: an analysis of the national cancer database
Comparison of neoadjuvant chemotherapy plus radiation vs. chemotherapy alone on complete pathologic response in pancreatic adenocarcinoma: an analysis of the national cancer database Open
View article: Development and Validation of a Predictive Risk Score for Blood Transfusion in Patients Undergoing Curative‐Intent Surgery for Intrahepatic Cholangiocarcinoma
Development and Validation of a Predictive Risk Score for Blood Transfusion in Patients Undergoing Curative‐Intent Surgery for Intrahepatic Cholangiocarcinoma Open
Background and Objectives Among patients undergoing liver resection for intrahepatic cholangiocarcinoma (ICC), perioperative bleeding requiring blood transfusion is a common complication, yet preoperative identification of patients at risk…
View article: Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma
Preoperative platelet count as an independent predictor of long‐term outcomes among patients undergoing resection for intrahepatic cholangiocarcinoma Open
Background and Objectives An elevated platelet count may reflect neoplastic and inflammatory states, with cytokine‐driven overproduction of platelets. The objective of this study was to evaluate the prognostic utility of high platelet coun…
View article: Hepatectomy <i>versus</i> systemic therapy for liver-limited <i>BRAF</i> V600E-mutated colorectal liver metastases: multicentre retrospective study
Hepatectomy <i>versus</i> systemic therapy for liver-limited <i>BRAF</i> V600E-mutated colorectal liver metastases: multicentre retrospective study Open
Background To date, only two studies have compared the outcomes of patients with liver-limited BRAF V600E-mutated colorectal liver metastases (CRLMs) managed with resection versus systemic therapy alone, and these have reported contradicto…
View article: ASO Author Reflections: Identifying and Understanding How Vulnerable Populations Are Affected by Delays in Pancreatic Cancer Care
ASO Author Reflections: Identifying and Understanding How Vulnerable Populations Are Affected by Delays in Pancreatic Cancer Care Open
View article: Minorities Face Delays to Pancreatic Cancer Treatment Regardless of Diagnosis Setting
Minorities Face Delays to Pancreatic Cancer Treatment Regardless of Diagnosis Setting Open
Introduction Our analysis was designed to characterize the demographics and disparities between the diagnosis of pancreas cancer during emergency presentation (EP) and the outpatient setting (OP) and to see the impact of our institutions p…
View article: Surgery for Oligometastatic Pancreatic Cancer: Defining Biologic Resectability
Surgery for Oligometastatic Pancreatic Cancer: Defining Biologic Resectability Open
Pancreatic ductal adenocarcinoma (PDAC) is most often metastatic at diagnosis. As systemic therapy continues to improve alongside advanced surgical techniques, the focus has shifted toward defining biologic, rather than technical, resectab…
View article: Does the Addition of Radiation to Neoadjuvant Systemic Therapy Improve Outcomes for Patients with Resected Pancreatic Adenocarcinoma? Analysis of the National Cancer Database
Does the Addition of Radiation to Neoadjuvant Systemic Therapy Improve Outcomes for Patients with Resected Pancreatic Adenocarcinoma? Analysis of the National Cancer Database Open
Purpose The incorporation of neoadjuvant radiation therapy into the treatment algorithm for pancreatic cancer is a topic of ongoing debate. This study compares neoadjuvant chemotherapy (NAC) alone to NAC combined with radiation (NAC + RT).…
View article: Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features
Early Onset Intrahepatic Cholangiocarcinoma: Clinical Characteristics, Oncological Outcomes, and Genomic/Transcriptomic Features Open
View article: Benchmarks in Liver Resection for Intrahepatic Cholangiocarcinoma
Benchmarks in Liver Resection for Intrahepatic Cholangiocarcinoma Open
View article: Caregiver‐reported quality of communication in pancreatic and periampullary cancer
Caregiver‐reported quality of communication in pancreatic and periampullary cancer Open
Background Communication between caregivers and clinical team members is critical for transitional care, but its quality and potential impact on outcomes are not well understood. This study reports on caregiver‐reported quality of communic…
View article: Classification of Intrahepatic Cholangiocarcinoma into Perihilar Versus Peripheral Subtype
Classification of Intrahepatic Cholangiocarcinoma into Perihilar Versus Peripheral Subtype Open
View article: Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies against self-antigens
Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies against self-antigens Open
Intratumoral B cell responses are associated with more favorable clinical outcomes in human pancreatic ductal adenocarcinoma (PDAC). However, the antigens driving these B cell responses are largely unknown. We sought to discover these anti…
View article: Development of a Neoadjuvant Treatment Pathway to Standardize Pancreatic Cancer Care and Improve Outcomes Across a Large Diverse Health System
Development of a Neoadjuvant Treatment Pathway to Standardize Pancreatic Cancer Care and Improve Outcomes Across a Large Diverse Health System Open
Background Management of localized pancreatic cancer is variable. We describe the development of a neoadjuvant therapy pathway (NATP) to standardize care across a large healthcare system. Methods We conducted an IRB-approved retrospective …
View article: An attempt to establish and apply global benchmarks for liver resection of malignant hepatic tumors
An attempt to establish and apply global benchmarks for liver resection of malignant hepatic tumors Open
View article: Profile of the Postoperative Care Provided for Patients With Pancreatic and Periampullary Cancers by Family and Unpaid Caregivers
Profile of the Postoperative Care Provided for Patients With Pancreatic and Periampullary Cancers by Family and Unpaid Caregivers Open
PURPOSE Patients with pancreatic and periampullary cancers may experience significant reduction in their quality of life and often rely on family and unpaid caregivers for assistance after surgery. However, as caregivers are not systematic…
View article: Supplementary Table S5 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas
Supplementary Table S5 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas Open
Supplementary Table S5;Diagnostic performance of telomerase activity in cases stratified by imaging features among discovery set cases
View article: Supplementary figures s1-s15 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas
Supplementary figures s1-s15 from Cyst Fluid Telomerase Activity Predicts the Histologic Grade of Cystic Neoplasms of the Pancreas Open
Figure S1: Coefficient of variation telomerase assay. Figure S2: Telomerase assay controls Figure S3; Serial dilution, limit of detection telomerase assay, Figure S4; Protein extraction and assay performance; Figure S5; Lack of telomerase …