Matthew Macowan
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View article: Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing Open
Early microbial colonization influences respiratory disease risk, yet mechanisms remain unclear. In a prospective birth cohort of 256 infants, we profiled bacterial, fungal, and viral communities in the upper airway and assessed local immu…
View article: Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Open
Prolonged exposure to a high-fat diet (HFD) exacerbates intestinal disease pathology, yet the early events preceding the development of gut inflammation remain poorly understood. Here, we show that within 48 h, HFD impairs intestinal group…
View article: A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats
A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats Open
Persistent post-surgical pain (PPSP) occurs in a proportion of patients following surgical interventions. Research suggests that specific microbiome components are important for brain development and function, with recent studies demonstra…
View article: A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes
A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes Open
Patients with a traumatic brain injury (TBI) are susceptible to hospital-acquired infections, presenting a significant challenge to an already-compromised immune system. The consequences and mechanisms by which this dual insult worsens out…
View article: Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma
Deep multiomic profiling reveals molecular signatures that underpin preschool wheeze and asthma Open
These factors highlighted distinctions between an inflammation-related phenotype in preschool wheeze, and the predominance of airway epithelial-related changes linked with the inferred trajectory toward asthma. These findings provide insig…
View article: Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury Open
View article: Multi‐omics integration reveals a nonlinear signature that precedes progression of lung fibrosis
Multi‐omics integration reveals a nonlinear signature that precedes progression of lung fibrosis Open
Objectives Idiopathic pulmonary fibrosis (IPF) is a devastating progressive interstitial lung disease with poor outcomes. While decades of research have shed light on pathophysiological mechanisms associated with the disease, our understan…
View article: Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats
Gut instinct: Sex differences in the gut microbiome are associated with changes in adolescent nociception following maternal separation in rats Open
Adolescent chronic pain is a growing public health epidemic. Our understanding of its etiology is limited; however, several factors can increase susceptibility, often developing in response to an acute pain trigger such as a surgical proce…
View article: The skin microbiome in the first year of life and its association with atopic dermatitis
The skin microbiome in the first year of life and its association with atopic dermatitis Open
Background Early‐life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between…
View article: Organotypic sinonasal airway culture systems are predictive of the mucociliary phenotype produced by bronchial airway epithelial cells
Organotypic sinonasal airway culture systems are predictive of the mucociliary phenotype produced by bronchial airway epithelial cells Open
Differentiated air–liquid interface models are the current standard to assess the mucociliary phenotype using clinically-derived samples in a controlled environment. However, obtaining basal progenitor airway epithelial cells (AEC) from th…
View article: Early life inter-kingdom interactions shape the immunological environment of the airways
Early life inter-kingdom interactions shape the immunological environment of the airways Open
Background There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are invo…
View article: The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD
The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD Open
View article: Interventional low‐dose azithromycin attenuates cigarette smoke‐induced emphysema and lung inflammation in mice
Interventional low‐dose azithromycin attenuates cigarette smoke‐induced emphysema and lung inflammation in mice Open
Cigarette smoke (CS)-induced emphysema is an important contributor to chronic obstructive pulmonary disease (COPD). We have shown the efficacy of azithromycin in reducing airway inflammation in COPD and in reducing exacerbations in severe …
View article: Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model
Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model Open
Background Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflamma…
View article: A NOVEL NORDIHYDROGUAIARERTIC ACID ANALOGUE, COMPOUND 3A, ALLEVIATES ACUTE LUNG INJURY BY EXHIBITING ITS ANTI‐INFLAMMATORY, ANTI‐OXIDATIVE AND ANTI‐APOPTOSIS EFFECTS
A NOVEL NORDIHYDROGUAIARERTIC ACID ANALOGUE, COMPOUND 3A, ALLEVIATES ACUTE LUNG INJURY BY EXHIBITING ITS ANTI‐INFLAMMATORY, ANTI‐OXIDATIVE AND ANTI‐APOPTOSIS EFFECTS Open
with antibiotics: Meropenem 1 gram/day, Ciprofloxacin 400 mg/day Fosfomycin 2 gram/day.Meropenem was given by intravenous electric syringe pump over approximately 3 hours.Ciprofloxacin was given by intravenous infusion one time a day.Fosfo…
View article: Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis
Effects of E‐cigarette E‐liquid components on bronchial epithelial cells: Demonstration of dysfunctional efferocytosis Open
Background and objective E‐cigarettes are often marketed and thought of as emitting harmless vapour; however, verification of their safety for non‐smokers is scarce. We have previously shown that E‐cigarettes cause decreased phagocytosis o…