Meredith C. McCormack
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Disparities in lung function trajectories among tobacco-exposed individuals Open
Background The relationship of social determinants of health (SDOH), environmental exposures and medical history to lung function trajectories is underexplored. A better understanding of these relationships could inform preventive strategi…
Greater ambient air pollution exposure is associated with worse respiratory symptoms in men and women with HIV and chronic lung disease: a cohort study Open
Background COPD and impairment in diffusing capacity for carbon monoxide (DLCO) are common comorbidities in people with HIV (PWH). HIV may increase susceptibility to inhaled toxins including air pollution. In PWH and people without HIV (PW…
Restriction with Normal Spirometry: A Retrospective Cohort Study Open
Background Though a normal forced vital capacity (FVC) is typically thought to imply the absence of restriction, recent data suggest that restriction may in fact be common among patients with normal spirometry. However, the clinical signif…
Unraveling the impact of indoor air pollution on respiratory health in people living with HIV within a high-prevalence HIV cohort Open
Background Chronic respiratory disease is a significant contributor to morbidity among persons living with HIV (PLWH). In the general population, indoor air pollution is associated with respiratory morbidity. There is limited data on the r…
Navigating data availability challenges in healthcare: assessing the added value of pulmonary function testing to the Care Assessment Need score for mortality risk Open
Objectives Pulmonary function testing (PFT) data, such as forced expiratory volume (FEV 1 ) has become increasingly siloed from the electronic health record (EHR). We hypothesised that FEV 1 %pred is independently associated with mortality…
Ambient Air Pollution Exposure and Mortality in the Pulmonary Hypertension Association Registry Open
Rationale The effects of long-term ambient air pollution exposure on survival in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) remain unclear. Objectives To evaluate the association between…
Mapping the Zone of Uncertainty in Pulmonary Function Test Interpretation Open
Background European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation posit the existence of a “zone of uncertainty.” However, as reference equations have been defined o…
Characteristics and Outcomes of People With COPD Who Experience Exacerbations While on Inhaled Triple Therapy: Results of the SIRIUS I Cohort Study in the US (2015–2019) Open
There is high mortality and considerable HCRU and healthcare costs incurred by people with COPD experiencing frequent moderate/severe exacerbations while on TT. Optimization of COPD management and new therapies are needed to reduce disease…
Association Between Hemoglobin A1c and Pediatric Asthma Control Open
Higher HbA1c levels were associated with worse asthma control among children with asthma, adding to evidence that metabolic dysfunction may influence asthma morbidity. Additionally, HbA1c could have a stronger influence among non-obese chi…
User-centred design for environmental data services   Open
To create tailored tools and solutions that improve our ability to mitigate and respond to environmental challenges, we need to understand how to efficiently communicate complex information to the intended audience.  One of the c…
View article: Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma
Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma Open
This study identified unique contributors to asthma in children with obesity and found novel pathways. Increased expression of IL-7R, IL-32, PARP-1, FKBP5 gene, IL-6, and Rho transcriptional signaling were observed in obese individuals wit…
Development and External Validation of a Machine Learning Model to Predict Restriction from Spirometry Open
Background Though European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation recommend the use of the forced vital capacity (FVC) lower limit of normal (LLN) to exclude …
Perceived Stress is Associated with Health Outcomes, Platelet Activation, and Oxidative Stress in COPD Open
Among former smokers with COPD, higher perceived stress is associated with worse respiratory outcomes. Platelet activation and oxidative stress may be biological pathways through which perceived stress plays a role in COPD.
View article: Iron Deficiency and All-Cause Hospitalization Risk in a Clinical Cohort of COPD
Iron Deficiency and All-Cause Hospitalization Risk in a Clinical Cohort of COPD Open
Iron deficiency may be associated with adverse outcomes in the absence of anemia, with non-anemic women being a COPD sub-population particularly sensitive to iron deficiency.
Brief Report: The Implications of Removing Race From Interpretation of Pulmonary Function Among Persons With or Without HIV Open
Background: Studies suggest that the use of race-specific pulmonary function reference equations may obscure racial inequities in respiratory health. Whether removing race from the interpretation of pulmonary function would influence analy…
View article: ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY
ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY Open
ObjectiveInsulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR to radiographic imaging outcomes and examiner-identified incident lung disea…
View article: ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY
ASSOCIATION OF INSULIN RESISTANCE WITH RADIOGRAPHIC LUNG ABNORMALITIES AND INCIDENT LUNG DISEASE: THE FRAMINGHAM OFFSPRING STUDY Open
ObjectiveInsulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR to radiographic imaging outcomes and examiner-identified incident lung disea…
View article: Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study
Association of Insulin Resistance With Radiographic Lung Abnormalities and Incident Lung Disease: The Framingham Offspring Study Open
OBJECTIVE Insulin resistance (IR) may be a risk factor for lung disease, but objective evidence is limited. We sought to define the relationship of longitudinal IR with radiographic imaging outcomes and examiner-identified incident lung di…
A Normal Forced Vital Capacity Does Not Reliably or Equitably Exclude Restriction Open
Background European Respiratory Society and American Thoracic Society (ERS/ATS) guidelines for pulmonary function test (PFT) interpretation recommend the use of a normal forced vital capacity (FVC) to exclude restriction. However, this rec…
Estimating rate of lung function change using clinical spirometry data Open
Rationale In chronic obstructive pulmonary disease (COPD), accurately estimating lung function from electronic health record (EHR) data would be beneficial but requires addressing complexities in clinically obtained testing. This study com…
Reply to Miller: Race-Specific Interpretation of Spirometry Open
"Reply to Miller: Race-Specific Interpretation of Spirometry." Annals of the American Thoracic Society, 0(ja), pp.