Matthew Moye
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View article: Hallmarks of neurodegenerative disease: A systems pharmacology perspective
Hallmarks of neurodegenerative disease: A systems pharmacology perspective Open
Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, are a rising public health concern and have been plagued by repeated drug development failures. The complex nature and poor mechanistic understand…
View article: Parametric Models for Clinical Measurements in Ophthalmology
Parametric Models for Clinical Measurements in Ophthalmology Open
The standard of care treatment for neovascular age-related macular degeneration, delivered as ocular injection, is based on anti-vascular endothelial growth factor (anti-VEGF). The course of treatment may need to be modified quickly for ce…
View article: The E3 ubiquitin ligase adaptor <i>Tango10</i> links the core circadian clock to neuropeptide and behavioral rhythms
The E3 ubiquitin ligase adaptor <i>Tango10</i> links the core circadian clock to neuropeptide and behavioral rhythms Open
Significance In animals, the control of daily sleep–wake rhythms is mediated by discrete circadian clock neurons via their rhythmic activity–dependent release of neuropeptides and neurotransmitters. Here, we describe a gene, Tango10 , crit…
View article: Author response: Daily electrical activity in the master circadian clock of a diurnal mammal
Author response: Daily electrical activity in the master circadian clock of a diurnal mammal Open
View article: Data Assimilation Methods for Neuronal State and Parameter Estimation
Data Assimilation Methods for Neuronal State and Parameter Estimation Open
This tutorial illustrates the use of data assimilation algorithms to estimate unobserved variables and unknown parameters of conductance-based neuronal models. Modern data assimilation (DA) techniques are widely used in climate science and…
View article: MOESM1 of Data Assimilation Methods for Neuronal State and Parameter Estimation
MOESM1 of Data Assimilation Methods for Neuronal State and Parameter Estimation Open
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