Matthew N. Poy
YOU?
Author Swipe
View article: Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases
Myeloid Cell Adhesion Molecule 1 (CADM1) Promotes Proinflammatory Signaling in Human Inflammatory Bowel Diseases Open
CADM1 is a mediator of proinflammatory signaling cascades in the colon and a potential therapeutic target for the IBDs.
View article: <i>Argonaute 2</i> in Neurons is essential for healthy Blood Brain Barrier Formation
<i>Argonaute 2</i> in Neurons is essential for healthy Blood Brain Barrier Formation Open
Background Argonaute2 ( Ago2 ) plays an essential role in RISC‐mediated silencing of target mRNAs, which are critical for cellular functions. Argonaute2 Syndrome, also known as Ago2 Syndrome, is a rare neurological disorder recently discov…
View article: Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice
Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice Open
Type 1 diabetes (T1D) is an autoimmune disease where pathogenic lymphocytes target autoantigens expressed in the pancreatic islets, leading to the destruction of insulin-producing β-cells. Zinc transporter 8 (ZnT8) is a major autoantigen a…
View article: Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice Open
Type 1 diabetes (T1D) is an autoimmune disease in which pathogenic lymphocytes target autoantigens expressed in pancreatic islets, leading to the destruction of insulin-producing β-cells. Zinc transporter 8 (ZnT8) is a major autoantigen ab…
View article: Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population
Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population Open
View article: Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction Open
View article: Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction Open
SUMMARY Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns)…
View article: Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes Open
BACKGROUNDPathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesi…
View article: <i>Atp6ap2</i> deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells
<i>Atp6ap2</i> deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells Open
Significance Cells maintain several mechanisms to ensure their survival, including the removal of old or damaged proteins and organelles. This process must be balanced: too little turnover results in the accumulation of cellular “junk,” wh…
View article: Control of hepatic gluconeogenesis by Argonaute2
Control of hepatic gluconeogenesis by Argonaute2 Open
These data illustrate a central role for Ago2 in the adaptive response of the liver to fasting. Ago2 mediates the suppression of AMPKα1 by miR-148a, thereby identifying a regulatory link between non-coding RNAs and a key stress regulator i…
View article: <scp>SORCS</scp> 1 and <scp>SORCS</scp> 3 control energy balance and orexigenic peptide production
<span>SORCS</span> 1 and <span>SORCS</span> 3 control energy balance and orexigenic peptide production Open
View article: The RhoGAP Stard13 controls insulin secretion through F-actin remodeling
The RhoGAP Stard13 controls insulin secretion through F-actin remodeling Open
View article: microRNA-184 Induces a Commitment Switch to Epidermal Differentiation
microRNA-184 Induces a Commitment Switch to Epidermal Differentiation Open
View article: Cadm2 regulates body weight and energy homeostasis in mice
Cadm2 regulates body weight and energy homeostasis in mice Open
View article: Pregnancy-Associated Plasma Protein-A2 and Anthropometry, Lifestyle, and Biochemical Factors in a Human Adult Population
Pregnancy-Associated Plasma Protein-A2 and Anthropometry, Lifestyle, and Biochemical Factors in a Human Adult Population Open
View article: Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects
Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects Open
Background To date, numerous nucleic acid species have been detected in the systemic circulation including microRNAs (miRNAs); however, their functional role in this compartment remains unclear. Objective The aim of this study was to deter…
View article: Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1 Open
Susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis. Genome-wide association studies have identified associations between body mass index and two loci near cell ad…
View article: MicroRNAs: An adaptive mechanism in the pancreatic β-cell…and beyond?
MicroRNAs: An adaptive mechanism in the pancreatic β-cell…and beyond? Open
View article: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity
SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity Open
In humans, genetic variation of sortilin-related receptor, L(DLR class) A repeats containing (SORL1), which encodes the intracellular sorting receptor SORLA, is a major genetic risk factor for familial and sporadic forms of Alzheimer's dis…
View article: The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
View article: Additional file 10: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 10: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of miR-342-3p mimic-regulated genes in RAW264.7 mouse macrophages. (XLSX 472 kb)
View article: Additional file 11: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 11: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of predicted mir-342-3p target genes with prediction scores. (XLSX 5370 kb)
View article: Additional file 5: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 5: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of human peripheral blood-derived monocytes and differentiating macrophage-expressed miRNAs. (XLSX 58 kb)
View article: Additional file 1: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 1: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of qPCR assays and primer sequences for gene expression analysis. (XLSX 11 kb)
View article: Additional file 7: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 7: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of IL-4-regulated miRNAs in WT and STAT6 KO macrophages. (XLSX 25 kb)
View article: Additional file 2: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p
Additional file 2: of The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p Open
List of primer sequences for ChIP-qPCR analysis and 3'UTR cloning. (XLSX 10 kb)
View article: miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism
miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism Open
View article: Insm1 cooperates with <scp>N</scp> eurod1 and <scp>F</scp> oxa2 to maintain mature pancreatic β‐cell function
Insm1 cooperates with <span>N</span> eurod1 and <span>F</span> oxa2 to maintain mature pancreatic β‐cell function Open