Matthew Neilson
YOU?
Author Swipe
View article: Quality of care should be a core consideration in health systems recovery from COVID-19
Quality of care should be a core consideration in health systems recovery from COVID-19 Open
Coronavirus disease-2019 (COVID-19) has shocked health systems globally, overwhelming rich and poor countries and highlighting both the need for and risks to quality care. Massive and persistent problems have been encountered in providing …
View article: Cardiac Adverse Events in Patients Receiving Immune Checkpoint Inhibitors in the Adjuvant Setting: An <scp>FDA</scp> Pooled Analysis
Cardiac Adverse Events in Patients Receiving Immune Checkpoint Inhibitors in the Adjuvant Setting: An <span>FDA</span> Pooled Analysis Open
Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. By releasing blocks (checkpoints) on the immune system, they elicit powerful antitumor effects. Despite improving survival, ICIs are associated with serio…
View article: <scp>PTEN</scp> deficiency exposes a requirement for an <scp>ARF GTPase</scp> module for integrin‐dependent invasion in ovarian cancer
<span>PTEN</span> deficiency exposes a requirement for an <span>ARF GTPase</span> module for integrin‐dependent invasion in ovarian cancer Open
Dysregulation of the PI3K/AKT pathway is a common occurrence in high‐grade serous ovarian carcinoma (HGSOC), with the loss of the tumour suppressor PTEN in HGSOC being associated with poor prognosis. The cellular mechanisms of how PTEN los…
View article: Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance
Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance Open
Objectives To assess key elements of the design for Meso-ORIGINS (Mesothelioma Observational study of RIsk prediction and Generation of paired benign-meso tissue samples, Including a Nested MRI Substudy), an ambitious, UK-wide, prospective…
View article: Country learning on maintaining quality essential health services during COVID-19 in Timor-Leste: a qualitative analysis
Country learning on maintaining quality essential health services during COVID-19 in Timor-Leste: a qualitative analysis Open
Objective This case study examines the enabling factors, strengths, challenges and lessons learnt from Timor-Leste (TLS) as it sought to maintain quality essential health services (EHS) during the COVID-19 pandemic. Design A qualitative ca…
View article: Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization Open
Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression by facilitating cell movement through physically constraining environments. To …
View article: Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization Open
Cancer cells are softer than the normal cells, and metastatic cells are even softer. These changes in biomechanical properties contribute to cancer progression by facilitating cell movement through physically constraining environments. To …
View article: Country Learning on Maintaining Quality Essential Health Services (EHS) during COVID-19 in Timor-Leste: A mixed methods qualitative analysis
Country Learning on Maintaining Quality Essential Health Services (EHS) during COVID-19 in Timor-Leste: A mixed methods qualitative analysis Open
Objective This research study examines the enabling factors, strengths, and challenges experienced by the Timor-Leste health system as it sought to maintain quality essential health services (EHS) during the COVID-19 pandemic. Design A mix…
View article: Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness Open
Background Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo-, and radiotherapy. A deeper understanding of the mechanisms inv…
View article: PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer
PTEN deficiency exposes a requirement for an ARF GTPase module in integrin-dependent invasion in ovarian cancer Open
Dysregulation of the PI3K/AKT pathway is a common occurrence in ovarian carcinomas. Loss of the tumour suppressor PTEN in high-grade serous ovarian carcinoma (HGSOC) is associated with a patient subgroup with poor prognosis. The cellular m…
View article: Joint External Evaluation scores and communicable disease deaths: An ecological study on the difference between epidemics and pandemics
Joint External Evaluation scores and communicable disease deaths: An ecological study on the difference between epidemics and pandemics Open
The Joint External Evaluation (JEE) assesses national capacities to implement the International Health Regulations (IHR). Previous studies have found that higher JEE scores are associated with fewer communicable disease deaths. But given t…
View article: Phase <scp>II</scp> proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer
Phase <span>II</span> proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer Open
Objectives To test for evidence of statin‐mediated effects in patients with castration‐resistant prostate cancer (CRPC) as post‐diagnosis use of statins in patients with prostate cancer is associated with favourable survival outcome. Patie…
View article: Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness Open
SUMMARY Background Infiltration of glioblastoma (GBM) throughout the brain leads to its inevitable recurrence following standard-of-care treatments, such as surgical resection, chemo- and radio-therapy. A deeper understanding of the mechan…
View article: Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion Open
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scatterin…
View article: S15 Evolution of mesothelioma following initial biopsies showing benign pleural inflammation: a meta-analysis
S15 Evolution of mesothelioma following initial biopsies showing benign pleural inflammation: a meta-analysis Open
Introduction Malignant Pleural Mesothelioma (MPM) is typically preceded by chronic pleural inflammation, providing a unique window for translational research. Within the PREDICT-Meso International Accelerator Network, the Meso-ORIGINS (Mes…
View article: Quality of health care and patient safety in extreme adversity settings in the Eastern Mediterranean Region: a qualitative multicountry assessment
Quality of health care and patient safety in extreme adversity settings in the Eastern Mediterranean Region: a qualitative multicountry assessment Open
Background: Quality and patient safety are essential for the provision of effective health care services. Research on these aspects is lacking in settings of extreme adversity. Aims: This study aimed to explore the perception of health car…
View article: Nuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness
Nuclear-capture of endosomes drives depletion of nuclear G-actin to promote SRF/MRTF gene expression and cancer cell invasiveness Open
Signals are relayed from receptor tyrosine kinases (RTKs) at the cell surface to effector systems in the cytoplasm and nucleus, and coordination of this process is important for the execution of migratory phenotypes, such as cell scatterin…
View article: Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth
Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth Open
As normal cells become cancer cells, and progress towards malignancy, they become progressively softer. Advantages of this change are that tumour cells become more deformable, and better able to move through narrow constraints. We designed…
View article: Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth
Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth Open
As normal cells become cancer cells, and progress towards malignancy, they become progressively softer. Advantages of this change are that tumour cells become more deformable, and better able to move through narrow constraints. We designed…
View article: Quality healthcare in extreme adversity: Developing a framework for action
Quality healthcare in extreme adversity: Developing a framework for action Open
Quality issue: Improving quality of care has become a global health priority to improve health outcomes and strengthen health systems, particularly in the context of achieving universal health coverage. Initial assessment: The delivery of …
View article: Quality health care in extreme adversity—an action framework
Quality health care in extreme adversity—an action framework Open
Quality problem or issue There are record-setting numbers of people living in settings of extreme adversity and they continue to increase each year. Initial assessment There is a paucity of validated data on quality and safety across setti…