Explanipedia

Turning Waste Into Insight: A Novel Proteomic Approach to Non-Invasive Wound Biomarker Discovery Open

Victoria Soto, Veronika Jurczuk, Lílian V. Tose, Christian Alcalde Pretel, Victoria Garcia , et al. · 2025

Chronic wounds such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) are a growing public health burden, contributing to significant morbidity, healthcare costs, and mortality. Current management strategies are hampered by the i…

Pre-clinical characterization of CSL040, a soluble complement receptor 1 (CR1) fragment Open

Sandra Wymann, Tanja Ruthsatz, Anjan K. Bongoni, Anup Nair, Yun Dai , et al. · 2025

P724: Expanding the matched annotation from NCBI and EMBL-EBI (MANE) dataset to include MANE Select for non-coding genes Open

Shashikant Pujar, Jane Loveland, Alex Astashyn, Ruth Bennett, Andrew C. Berry , et al. · 2025

Ensembl 2025 Open

Sarah Dyer, Olanrewaju Austine-Orimoloye, Andrey G Azov, Matthieu Barba, If Barnes , et al. · 2024

Ensembl (www.ensembl.org) is an open platform integrating publicly available genomics data across the tree of life with a focus on eukaryotic species related to human health, agriculture and biodiversity. This year has seen a continued exp…

GENCODE 2025: reference gene annotation for human and mouse Open

Jonathan M. Mudge, Sílvia Carbonell Sala, Mark Diekhans, José M. González, Toby Hunt , et al. · 2024

GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-increasing granularit…

GENCODE: massively expanding the lncRNA catalog through capture long-read RNA sequencing Open

Gazaldeep Kaur, Tamara Perteghella, Sílvia Carbonell Sala, José M. González, Toby Hunt , et al. · 2024

Accurate and complete gene annotations are indispensable for understanding how genome sequences encode biological functions. For twenty years, the GENCODE consortium has developed reference annotations for the human and mouse genomes, beco…

Ensembl 2024 Open

Peter W. Harrison, M Ridwan Amode, Olanrewaju Austine-Orimoloye, Andrey G Azov, Matthieu Barba , et al. · 2023

Ensembl (https://www.ensembl.org) is a freely available genomic resource that has produced high-quality annotations, tools, and services for vertebrates and model organisms for more than two decades. In recent years, there has been a drama…

Assessing student perception of the integration of portable wireless ultrasound imaging in undergraduate anatomy education Open

Hope Edwards, Huw S. Jones, Pip Garner, Matthew P. Hardy, Stacy‐Paul Wilshaw , et al. · 2023

Anatomy is the foundation of many physiology and healthcare‐related degrees. With limited access to cadavers in many universities, it is essential to investigate techniques that could be utilized to support and enhance the teaching of anat…

P539: Fostering a common language in clinical genomics: MANE Select as a universal standard to report clinical variants Open

Shashikant Pujar, Jane Loveland, Alex Astashyn, Ruth Bennett, Andrew C. Berry , et al. · 2023

GENCODE: reference annotation for the human and mouse genomes in 2023 Open

Adam Frankish, Sílvia Carbonell Sala, Mark Diekhans, Irwin Jungreis, Jane Loveland , et al. · 2022

GENCODE produces high quality gene and transcript annotation for the human and mouse genomes. All GENCODE annotation is supported by experimental data and serves as a reference for genome biology and clinical genomics. The GENCODE consorti…

Ensembl 2023 Open

Fergal J. Martin, M Ridwan Amode, Alisha Aneja, Olanrewaju Austine-Orimoloye, Andrey G Azov , et al. · 2022

Ensembl (https://www.ensembl.org) has produced high-quality genomic resources for vertebrates and model organisms for more than twenty years. During that time, our resources, services and tools have continually evolved in line with both th…

Soluble Complement Receptor 1 Therapeutics Open

Matthew P. Hardy, Tony Rowe, Sandra Wymann · 2022

Human Complement Receptor 1 (CR1/CD35) is a potent negative regulator of the complement system. Its mechanism of action is through interaction with the complement activation fragments, C3b and C4b to mediate decay acceleration of the C3 an…

A joint NCBI and EMBL-EBI transcript set for clinical genomics and research Open

Joannella Morales, Shashikant Pujar, Jane Loveland, Alex Astashyn, Ruth Bennett , et al. · 2022

Comprehensive genome annotation is essential to understand the impact of clinically relevant variants. However, the absence of a standard for clinical reporting and browser display complicates the process of consistent interpretation and r…

A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury Open

Anjan K. Bongoni, Ingela B. Vikstrom, Jennifer L. McRae, Evelyn Salvaris, Nella Fisicaro , et al. · 2021

Ensembl 2022 Open

Fiona Cunningham, James E. Allen, Jamie Allen, Jorge Álvarez-Jarreta, M Ridwan Amode , et al. · 2021

Ensembl (https://www.ensembl.org) is unique in its flexible infrastructure for access to genomic data and annotation. It has been designed to efficiently deliver annotation at scale for all eukaryotic life, and it also provides deep compre…

Modular Platform for the Development of Recombinant Hemoglobin Scavenger Biotherapeutics Open

Raphael M. Buzzi, Catherine M. Owczarek, Kevin Akeret, Andrea Tester, Natasha Pereira , et al. · 2021

Cell-free hemoglobin (Hb) is a driver of disease progression in conditions with intravascular or localized hemolysis. Genetic and acquired anemias or emergency medical conditions such as aneurysmal subarachnoid hemorrhage involve tissue Hb…

Responding to Sexual Boundary Notifications: The Evolving Regulatory Approach in Australia Open

Christine E. Gee, Anne Tonkin, Sharon Gaby, Veronika Urh, Sarah Anderson , et al. · 2021

A sexual boundary violation by a health practitioner has an immense impact on a patient, and the trust and confidence in the health care system and the health care regulator are negatively affected. The Australian Health Practitioner Regul…

A novel soluble complement receptor 1 fragment with enhanced therapeutic potential Open

Sandra Wymann, Yun Dai, Anup G. Nair, Helen Cao, Glenn A. Powers , et al. · 2021

Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated clea…

GENCODE 2021 Open

Adam Frankish, Mark Diekhans, Irwin Jungreis, Julien Lagarde, Jane Loveland , et al. · 2020

The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make …

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons Open