Matthew Perez
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View article: Case Report: Durable response to tumor-infiltrating lymphocyte therapy in a patient with metastatic melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma
Case Report: Durable response to tumor-infiltrating lymphocyte therapy in a patient with metastatic melanoma and chronic lymphocytic leukemia/small lymphocytic lymphoma Open
Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy for the treatment of immune checkpoint therapy-resistant/refractory advanced melanoma patients. However, its safety and efficacy remain to be determined among patients w…
View article: 1346 Molecular and immunologic correlates of response in a phase II study of neoadjuvant lenvatinib plus pembrolizumab in Merkel cell carcinoma
1346 Molecular and immunologic correlates of response in a phase II study of neoadjuvant lenvatinib plus pembrolizumab in Merkel cell carcinoma Open
View article: Engineering Fusion Proteins for Nanomedicine-Based Cytokine Therapy
Engineering Fusion Proteins for Nanomedicine-Based Cytokine Therapy Open
Cytokines play a crucial role in cell communication and immunity, making them interesting potential therapeutics for immune-mediated conditions. However, cytokine therapeutics' clinical translation is hampered by their short blood half-liv…
View article: 451 CD40L-4–1BB can stimulate tumor infiltrating lymphocyte <i>ex vivo</i> expansion from melanoma core biopsies
451 CD40L-4–1BB can stimulate tumor infiltrating lymphocyte <i>ex vivo</i> expansion from melanoma core biopsies Open
View article: Enhancing Access to Orthopedic Education: Exploring the Potential of Generative Artificial Intelligence (AI) in Improving Health Literacy on Rotator Cuff Injuries
Enhancing Access to Orthopedic Education: Exploring the Potential of Generative Artificial Intelligence (AI) in Improving Health Literacy on Rotator Cuff Injuries Open
Our study determined that generative AI is capable of rewriting PEMs about RCI at a reading comprehension level that conforms to the CDC and NIH guidelines. Hospital administrators and orthopedic surgeons should consider the findings of th…
View article: 450 Pooled analysis of efficacy outcomes from early-phase trials of tumor infiltrating lymphocyte therapy in advanced melanoma
450 Pooled analysis of efficacy outcomes from early-phase trials of tumor infiltrating lymphocyte therapy in advanced melanoma Open
View article: FluencyBank Timestamped: An Updated Data Set for Disfluency Detection and Automatic Intended Speech Recognition
FluencyBank Timestamped: An Updated Data Set for Disfluency Detection and Automatic Intended Speech Recognition Open
Purpose: This work introduces updated transcripts, disfluency annotations, and word timings for FluencyBank, which we refer to as FluencyBank Timestamped. This data set will enable the thorough analysis of how speech processing models (suc…
View article: Beyond Binary: Multiclass Paraphasia Detection with Generative Pretrained Transformers and End-to-End Models
Beyond Binary: Multiclass Paraphasia Detection with Generative Pretrained Transformers and End-to-End Models Open
Aphasia is a language disorder that can lead to speech errors known as paraphasias, which involve the misuse, substitution, or invention of words. Automatic paraphasia detection can help those with Aphasia by facilitating clinical assessme…
View article: Combination Atezolizumab, Cobimetinib, and Vemurafenib as a Treatment Option in BRAF V600 Mutation–Positive Melanoma: Patient Selection and Perspectives
Combination Atezolizumab, Cobimetinib, and Vemurafenib as a Treatment Option in BRAF V600 Mutation–Positive Melanoma: Patient Selection and Perspectives Open
The treatment landscape for advanced and metastatic melanoma has drastically changed in recent years, with the advent of novel therapeutic options such as immune checkpoint inhibitors and targeted therapies offering remarkable efficacy and…
View article: Clinical Characteristics and Special Considerations in the Management of Rare Melanoma Subtypes
Clinical Characteristics and Special Considerations in the Management of Rare Melanoma Subtypes Open
Rare histologic subtypes of melanoma, including acral, mucosal, uveal, and desmoplastic melanomas, only make up 5% of all diagnosed melanomas and are often underrepresented in large, randomized trials. Recent advancements in systemic thera…
View article: Intralesional and Infusional Updates for Metastatic Melanoma
Intralesional and Infusional Updates for Metastatic Melanoma Open
Locoregionally advanced and metastatic melanoma represent a challenging clinical problem, but in the era of immune checkpoint blockade and intralesional and infusional therapies, more options are available for use. Isolated limb infusion (…
View article: Management of acral lentiginous melanoma: current updates and future directions
Management of acral lentiginous melanoma: current updates and future directions Open
Acral lentiginous melanoma is a rare subtype of melanoma generally associated with poor outcomes, even when diagnosed at an early stage. The tumor genetic profile remains poorly understood, but it is known to have a suppressed immune envir…
View article: Troponin Elevation in Patients Undergoing Percutaneous Hepatic Perfusion for Metastatic Uveal Melanoma
Troponin Elevation in Patients Undergoing Percutaneous Hepatic Perfusion for Metastatic Uveal Melanoma Open
Background Percutaneous Hepatic Perfusion (PHP) is a liver directed regional therapy recently FDA approved for metastatic uveal melanoma to the liver involving percutaneous isolation of liver, saturation of the entire liver with high-dose …
View article: Machine Learning Approaches for Quantitative Analysis and Characterization of Pathological Speech Disorders
Machine Learning Approaches for Quantitative Analysis and Characterization of Pathological Speech Disorders Open
Automatic quantitative analyses for characterizing pathological speech have the potential to aid medical professionals in assessing disease severity. Pathological speech disorders can manifest in a variety of ways, which creates an opportu…
View article: Seq2seq for Automatic Paraphasia Detection in Aphasic Speech
Seq2seq for Automatic Paraphasia Detection in Aphasic Speech Open
Paraphasias are speech errors that are often characteristic of aphasia and they represent an important signal in assessing disease severity and subtype. Traditionally, clinicians manually identify paraphasias by transcribing and analyzing …
View article: Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver
Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver Open
Patients with cutaneous melanoma can develop in-transit metastases (ITM), most often localized to limbs. For patients with uveal melanoma that develop metastatic disease, the overall majority develop isolated liver metastases. For these ty…
View article: How do I interpret and use quantitative buprenorphine and norbuprenorphine urine levels?
How do I interpret and use quantitative buprenorphine and norbuprenorphine urine levels? Open
Confirmatory testing of urine samples can be useful in outpatient settings where buprenorphine dosing is not directly observed. But retaining and engaging the patient in effective treatment should be the ultimate goals of testing.
View article: Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection
Outcomes with adjuvant anti-PD-1 therapy in patients with sentinel lymph node-positive melanoma without completion lymph node dissection Open
Until recently, most patients with sentinel lymph node-positive (SLN+) melanoma underwent a completion lymph node dissection (CLND), as mandated in published trials of adjuvant systemic therapies. Following multicenter selective lymphadene…
View article: Potential Impact of Revised NCI Eligibility Criteria Guidance: Prior Malignancy Exclusion in Breast Cancer Clinical Trials
Potential Impact of Revised NCI Eligibility Criteria Guidance: Prior Malignancy Exclusion in Breast Cancer Clinical Trials Open
Background: Many individuals with cancer have survived a prior cancer and for this reason may have been excluded from clinical trials. Recent NCI guidance recommends including these individuals, especially when the risk of the prior malign…
View article: Articulatory Coordination for Speech Motor Tracking in Huntington Disease
Articulatory Coordination for Speech Motor Tracking in Huntington Disease Open
Huntington Disease (HD) is a progressive disorder which often manifests in motor impairment. Motor severity (captured via motor score) is a key component in assessing overall HD severity. However, motor score evaluation involves in-clinic …
View article: Automatically Detecting Errors and Disfluencies in Read Speech to Predict Cognitive Impairment in People with Parkinson&#8217;s Disease
Automatically Detecting Errors and Disfluencies in Read Speech to Predict Cognitive Impairment in People with Parkinson’s Disease Open
Parkinson's disease (PD) is a central nervous system disorder that causes motor impairment. Recent studies have found that people with PD also often suffer from cognitive impairment (CI). While a large body of work has shown that speech ca…
View article: Active surveillance of patients who have sentinel node positive melanoma: An international, multi‐institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy Trial II (MSLT‐2)
Active surveillance of patients who have sentinel node positive melanoma: An international, multi‐institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy Trial II (MSLT‐2) Open
Background For patients with sentinel lymph node (SLN)‐positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease‐specific survival (DSS) with active surveillance using nodal ultraso…
View article: Learning Paralinguistic Features from Audiobooks through Style Voice Conversion
Learning Paralinguistic Features from Audiobooks through Style Voice Conversion Open
Zakaria Aldeneh, Matthew Perez, Emily Mower Provost. Proceedings of the 2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2021.
Surveillance of Sentinel Node-Positive Melanoma Patients with Reasons for Exclusion from MSLT-II: Multi-Institutional Propensity Score Matched Analysis Open
View article: Aphasic Speech Recognition Using a Mixture of Speech Intelligibility Experts
Aphasic Speech Recognition Using a Mixture of Speech Intelligibility Experts Open
Robust speech recognition is a key prerequisite for semantic feature extraction in automatic aphasic speech analysis. However, standard one-size-fits-all automatic speech recognition models perform poorly when applied to aphasic speech. On…
View article: Aphasic Speech Recognition using a Mixture of Speech Intelligibility Experts
Aphasic Speech Recognition using a Mixture of Speech Intelligibility Experts Open
Robust speech recognition is a key prerequisite for semantic feature extraction in automatic aphasic speech analysis. However, standard one-size-fits-all automatic speech recognition models perform poorly when applied to aphasic speech. On…
View article: Correction to: Merkel Cell Carcinoma Outcomes: Does AJCC8 Underestimate Survival?
Correction to: Merkel Cell Carcinoma Outcomes: Does AJCC8 Underestimate Survival? Open
View article: Local and Recurrent Regional Metastases of Melanoma
Local and Recurrent Regional Metastases of Melanoma Open
Up to 10% of patients with cutaneous melanoma will develop recurrent locoregional disease. While surgical resection remains the mainstay of treatment for isolated recurrences, locoregional melanoma can often present as bulky, unresectable …
View article: Observational Study of Talimogene Laherparepvec use for Melanoma in Clinical Practice in the United States (COSMUS-1)
Observational Study of Talimogene Laherparepvec use for Melanoma in Clinical Practice in the United States (COSMUS-1) Open
T-VEC was well tolerated and showed clinical utility.
View article: Re-Biopsy of Partially Sampled thin Melanoma Impacts Sentinel Lymph Node Sampling as well as Surgical Margins
Re-Biopsy of Partially Sampled thin Melanoma Impacts Sentinel Lymph Node Sampling as well as Surgical Margins Open
Re-biopsy led to sentinel lymph node biopsy (SLNB) in 18.3% of cases. No patients upstaged from AMP or MIS had a positive SLNB. One out of nine (11.1%) initially diagnosed as a thin melanoma ≤0.75 mm, upstaged with a re-biopsy, had a posit…