Matthew C. Pickering
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View article: #3391 Pegcetacoplan treatment appears to halt disease progression in C3G and primary (idiopathic) IC-MPGN patients: results from the phase 3 VALIANT study
#3391 Pegcetacoplan treatment appears to halt disease progression in C3G and primary (idiopathic) IC-MPGN patients: results from the phase 3 VALIANT study Open
Background and Aims C3 glomerulopathy (C3G) and primary (idiopathic) immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases where uncontrolled C3 activation results in excessive glomerular deposition of C3 brea…
View article: Temporal multi-omics analysis of COVID-19 in end-stage kidney disease
Temporal multi-omics analysis of COVID-19 in end-stage kidney disease Open
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. We performed longitudinal single-cell immune profiling of ESKD patients with COVID-19. Transcriptome, surface proteome, and immunoreceptor sequencing data w…
View article: Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus
Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus Open
Objective Rituximab, a CD20 + B cell depletion therapy, is frequently used in the treatment of systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying im…
View article: P191 Low density neutrophils in ANCA-Associated Vasculitis
P191 Low density neutrophils in ANCA-Associated Vasculitis Open
Background/Aims Anti-Neutrophil Cytoplasm Antibody (ANCA)-Associated Vasculitis (AAV) is an autoimmune disease typified by antibodies that target neutrophil proteins, myeloperoxidase and proteinase-3. Neutrophil populations in patients wit…
View article: Temporal multi-omic analysis of COVID-19 in end-stage kidney disease
Temporal multi-omic analysis of COVID-19 in end-stage kidney disease Open
Summary Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. We performed longitudinal single cell multi-omic immune profiling of ESKD patients with COVID- 19, sampled during two waves of the pandemic. Uniquel…
View article: Developing Therapies for C3 Glomerulopathy
Developing Therapies for C3 Glomerulopathy Open
Randomized clinical trials are underway to evaluate the efficacy of novel agents targeting the alternative complement pathway in patients with C3 glomerulopathy (C3G), a rare glomerular disease. The Kidney Health Initiative convened a pane…
View article: Canonical and noncanonical functions of complement in systemic lupus erythematosus
Canonical and noncanonical functions of complement in systemic lupus erythematosus Open
For many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissu…
View article: WCN24-683 EFFICACY OF 12-WEEK PEGCETACOPLAN IN KIDNEY TRANSPLANT RECIPIENTS WITH RECURRENT C3 GLOMERULOPATHY (C3G) OR IMMUNE COMPLEX MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (IC-MPGN)
WCN24-683 EFFICACY OF 12-WEEK PEGCETACOPLAN IN KIDNEY TRANSPLANT RECIPIENTS WITH RECURRENT C3 GLOMERULOPATHY (C3G) OR IMMUNE COMPLEX MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (IC-MPGN) Open
Pegcetacoplan (PEG; C3 inhibitor) may prevent C3G or IC-MPGN progression. NOBLE (NCT04572854) is the first prospective randomized controlled trial of PEG vs standard of care (SOC) in kidney transplant recipients (KTRs) with primary C3G or …
View article: The genetics and epidemiology of<i>N-</i>and<i>O-</i>IgA glycomics
The genetics and epidemiology of<i>N-</i>and<i>O-</i>IgA glycomics Open
Immunoglobulin (Ig) glycosylation modulates the immune response, and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylati…
View article: Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil
Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil Open
Background Systemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell f…
View article: A novel mutation in EROS (<i>CYBC1</i>) causes Chronic Granulomatous Disease
A novel mutation in EROS (<i>CYBC1</i>) causes Chronic Granulomatous Disease Open
Chronic Granulomatous Disease (CGD) is an inborn error of immunity characterised by opportunistic infection and sterile granulomatous inflammation. CGD is caused by a failure of reactive oxygen species (ROS) production by the phagocyte NAD…
View article: Supplementary Tables from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Supplementary Tables from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
Supplementary tables 1-5
View article: Supplementary Tables from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Supplementary Tables from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
Supplementary tables 1-5
View article: Data from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Data from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
The complement system is a powerful and druggable innate immune component of the tumor microenvironment. Nevertheless, it is challenging to elucidate the exact mechanisms by which complement affects tumor growth. In this study, we examined…
View article: Supplementary Figures from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Supplementary Figures from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
Supplementary figures
View article: Supplementary Figures from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Supplementary Figures from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
Supplementary figures
View article: Data from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
Data from Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade Open
The complement system is a powerful and druggable innate immune component of the tumor microenvironment. Nevertheless, it is challenging to elucidate the exact mechanisms by which complement affects tumor growth. In this study, we examined…
View article: Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence
Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence Open
Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here, we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19, collecting samples pre-infection, serially during infection, and …
View article: Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis
Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis Open
Background and objectives C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approxi…