Explanipedia

Dissociating the effects of dopamine D2 receptors on effort-based versus value-based decision making using a novel behavioral approach. Open

Matthew R. Bailey, Eileen K. Chun, Elke Schipani, Peter D. Balsam, Eleanor H. Simpson · 2020

Cost-benefit decision making is essential for organisms to adapt to their ever-changing environment. Most studies of cost-benefit decision making involve choice conditions in which effort and value are varied simultaneously. This prevents …

Updates from the 7th Q&A with the USDA Open

B. Taylor Bennett, Matthew R. Bailey · 2019

Evidence for a Mixed Timing and Counting Strategy in Mice Performing a Mechner Counting Task Open

Kenneth Light, Brian Cotten, Talia Malekan, Sophie Dewil, Matthew R. Bailey , et al. · 2019

Numerosity, or the ability to understand and distinguish between discrete quantities, was first formalized for study in animals by Mechner (1958a). Rats had to press one lever (the counting lever) n times to arm food release from pr…

Taking a closer look at the USDA inspection process in FY 2018 Open

B. Taylor Bennett, Matthew R. Bailey · 2019

Update on the Oversight of Animal Care and Use Programs Open

B. Taylor Bennett, Matthew R. Bailey · 2019

Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost Open

Ina Filla, Matthew R. Bailey, Elke Schipani, Vanessa Winiger, Christopher Mezias , et al. · 2018

Addressing administrative burden: a primer for submitting comments to the USDA and OLAW Open

B. Taylor Bennett, Matthew R. Bailey · 2018

An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice Open

Matthew R. Bailey, Olivia V. Goldman, Estefanía P. Bello, Muhammad O. Chohan, Nuri Jeong , et al. · 2018

The functionally selective 5-HT2C receptor ligand SB242084 can increase motivation and have rapid onset anti–depressant-like effects. We sought to identify the specific behavioral effects of SB242084 treatment and elucidate the mechanism i…

A corticostriatal deficit promotes temporal distortion of automatic action in ageing Open

Miriam Matamales, Zala Skrbis, Matthew R. Bailey, Peter D. Balsam, Bernard W. Balleine , et al. · 2017

The acquisition of motor skills involves implementing action sequences that increase task efficiency while reducing cognitive loads. This learning capacity depends on specific cortico-basal ganglia circuits that are affected by normal agei…

Author response: A corticostriatal deficit promotes temporal distortion of automatic action in ageing Open

Miriam Matamales, Zala Skrbis, Matthew R. Bailey, Peter D. Balsam, Bernard W. Balleine , et al. · 2017

Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The acquisition of motor skills involves implementing action…

Policy watch: revisions to the Animal Welfare Inspection Guide Open

B. Taylor Bennett, Matthew R. Bailey · 2017

Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization Open

Abigail M. Clark, Félix Leroy, Kelly Martyniuk, Wendy Feng, Erika McManus , et al. · 2017

Alterations in thalamic dopamine (DA) or DA D2 receptors (D2Rs) have been measured in drug addiction and schizophrenia, but the relevance of thalamic D2Rs for behavior is largely unknown. Using in situ hybridization and mice expressing gre…

USDA's removal of information from their website Open

B. Taylor Bennett, Matthew R. Bailey · 2017

Policy watch: adapting to change in the animal care and use oversight environment Open

B. Taylor Bennett, Matthew R. Bailey · 2017

An Examination of Goal-Directed Motivation in Mice: The Role of Dopamine D2 and Serotonin 2C Receptors Open

Matthew R. Bailey · 2017

Motivation has been defined as a set of processes which enables organisms to overcome obstacles by energizing behavior in the pursuit of a goal. There are several important observations about motivated behavior which provide insight into t…

Keeping current with regulations and requirements Open

B. Taylor Bennett, Matthew R. Bailey · 2016

Neural substrates underlying effort, time, and risk-based decision making in motivated behavior Open

Matthew R. Bailey, Eleanor H. Simpson, Peter D. Balsam · 2016

Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action Open

Fernanda Carvalho Poyraz, E. Hölzner, Matthew R. Bailey, József Mészáros, Lindsay Kenney , et al. · 2016

Altered dopamine D2 receptor (D2R) binding in the striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schizophrenia. Here, we tested whether motivational deficits observed in mice with upregulated…

Use of FOIA by animal rights activists Open

B. Taylor Bennett, Andrew D. Cardon, Matthew R. Bailey · 2016

The effects of pharmacological modulation of the serotonin 2C receptor on goal-directed behavior in mice Open

Matthew R. Bailey, Cait M. Williamson, Christopher Mezias, Vanessa Winiger, Rae Silver , et al. · 2015

A novel strategy for dissecting goal-directed action and arousal components of motivated behavior with a progressive hold-down task. Open

Matthew R. Bailey, Greg Jensen, Kathleen Taylor, Christopher Mezias, Cait M. Williamson , et al. · 2015

Motivation serves 2 important functions: It guides actions to be goal-directed, and it provides the energy and vigor required to perform the work necessary to meet those goals. Dissociating these 2 processes with existing behavioral assays…

Revisions to the Animal Welfare Inspection Guide Open

B. Taylor Bennett, Andrew D. Cardon, Matthew R. Bailey · 2015

FOIA in your state Open

Andrew D. Cardon, B. Taylor Bennett, Matthew R. Bailey · 2015

Matthew R. Bailey YOU? Author Swipe