Matthew R. Harter
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View article: The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2
The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2 Open
The CUT and homeodomain are ubiquitous DNA binding elements often tandemly arranged in multiple transcription factor families. However, how the CUT and homeodomain work concertedly to bind DNA remains unknown. Using ONECUT2, a driver and t…
View article: The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2
The homeodomain drives favorable DNA binding energetics of prostate cancer target ONECUT2 Open
The ONECUT transcription factors feature a CUT and a homeodomain, evolutionarily conserved elements that bind DNA cooperatively, but the process remains mechanistically enigmatic. Using an integrative DNA binding analysis of ONECUT2, a dri…
View article: EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics Open
View article: BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2
BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2 Open
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) plays an important role in driving immortalization of EBV-infected B cells through regulating the expression of many viral and cellular genes. We report a structural study of the tumor sup…
View article: Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration
Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration Open