James Walters
YOU?
Author Swipe
View article: 1H-MRS metabolites in antipsychotic-responsive versus non-responsive psychosis: a meta- and mega-analysis.
1H-MRS metabolites in antipsychotic-responsive versus non-responsive psychosis: a meta- and mega-analysis. Open
Understanding the mechanisms underlying the response to antipsychotic medications is critical for refining targets for new interventions and predicting clinical outcomes. This study presents a mega-analysis of individual participant data (…
View article: Disentangling Perinatal Depression from General Major Depression: A GWAS Meta-Analysis and Genetic Correlation Approach in European Datasets
Disentangling Perinatal Depression from General Major Depression: A GWAS Meta-Analysis and Genetic Correlation Approach in European Datasets Open
Perinatal depression (PND), defined as depression occurring during the perinatal period, has a higher heritability than general major depressive disorder (MDD) yet remains understudied. This study aimed to increase power in PND GWAS and ex…
View article: Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences
Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences Open
We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulativ…
View article: Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort
Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort Open
Depression is associated with immunological and metabolic alterations, but immunometabolic characteristics of developmental trajectories of depressive symptoms remain unclear. Studies of longitudinal trends of depressive symptoms in young …
View article: The impact of genetic and sociodemographic factors on life course trajectories of physical-mental health multimorbidity in a UK South Asian cohort
The impact of genetic and sociodemographic factors on life course trajectories of physical-mental health multimorbidity in a UK South Asian cohort Open
Background UK South Asian populations have a high risk of many cardiometabolic and internalising mental health conditions such as depression and anxiety, and they commonly co-exist as physical and mental health multimorbidity. However, the…
View article: Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects
Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects Open
Rationale Antipsychotic medications are the first-line treatment for schizophrenia. Around 40% of people who are treated with antipsychotics could develop extrapyramidal side-effects (EPSE) including: (1) Dyskinesia, (2) Parkinsonism, (3) …
View article: Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans
Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans Open
Background Major Depressive Disorder (MDD) is a disabling condition that arises from the interplay of genetic and environmental risk factors. Most genetic studies of depression to date have failed to include continental African populations…
View article: 39. NEURODEVELOPMENTAL COPY NUMBER VARIANTS INCREASE RISK OF INTERNALISING AND CARDIOMETABOLIC MULTIMORBIDITY
39. NEURODEVELOPMENTAL COPY NUMBER VARIANTS INCREASE RISK OF INTERNALISING AND CARDIOMETABOLIC MULTIMORBIDITY Open
View article: Estimating disorder probability based on polygenic prediction using the BPC approach
Estimating disorder probability based on polygenic prediction using the BPC approach Open
View article: Combined family history and polygenic score prediction of major depressive disorder
Combined family history and polygenic score prediction of major depressive disorder Open
Importance Major depressive disorder (MDD) is a complex psychiatric disorder influenced by genetic, social, and environmental factors. Family history, genome-wide polygenic scores, and childhood trauma are key predictors of MDD onset with …
View article: Change in Cognition Following Ischaemic Stroke
Change in Cognition Following Ischaemic Stroke Open
Objective Cognitive decline can occur following ischaemic stroke. How cognition changes over time and associations with cognitive change are poorly understood. This study aimed to explore these issues over 2 years following ischaemic strok…
View article: Acceptability of the Cardiff ONline Cognitive Assessment (CONCA), a web-based tool for clinical assessment of cognition in patients with psychosis: Protocol for a mixed methods study (Preprint)
Acceptability of the Cardiff ONline Cognitive Assessment (CONCA), a web-based tool for clinical assessment of cognition in patients with psychosis: Protocol for a mixed methods study (Preprint) Open
BACKGROUND Early detection of cognitive impairments in individuals with psychosis offers a means to support clinical and functional recovery. However, there are significant barriers to assessing cognition in clinical services, including l…
View article: Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort
Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort Open
Background Some psychotic experiences in the general population show associations with higher schizophrenia and other mental health-related polygenic risk scores (PRSs), but studies have not usually included interviewer-rated positive, neg…
View article: Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank
Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank Open
View article: The relationship between schizophrenia polygenic scores, blood-based proteins and psychosis diagnosis in the UK Biobank
The relationship between schizophrenia polygenic scores, blood-based proteins and psychosis diagnosis in the UK Biobank Open
Despite notable progress in psychiatric genomics, there are no validated blood-based biomarkers for psychosis. Previous studies have failed to establish a link between schizophrenia polygenic scores (PGS) and blood protein levels. We aimed…
View article: Whole-exome sequencing analysis identifies risk genes for schizophrenia
Whole-exome sequencing analysis identifies risk genes for schizophrenia Open
Rare coding variants across many genes contribute to schizophrenia liability, but they have only been implicated in 12 genes at exome-wide levels of significance. To increase power for gene discovery, we analyse exome-sequencing data for r…
View article: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk Open
View article: Using Passive Sensing to Predict Psychosis Relapse: An In-Depth Qualitative Study Exploring Perspectives of People With Psychosis
Using Passive Sensing to Predict Psychosis Relapse: An In-Depth Qualitative Study Exploring Perspectives of People With Psychosis Open
Background Relapses result in negative consequences for individuals with psychosis and considerable health service costs. Digital remote monitoring (DRM) systems incorporating “passive sensing” (sensor data gathered via smartphones/wearabl…
View article: Genome-wide insights into generalised anxiety using a dimensional symptom severity approach
Genome-wide insights into generalised anxiety using a dimensional symptom severity approach Open
We performed a genome-wide association meta-analysis of generalised anxiety symptom severity in 696,563 individuals of European ancestry from 14 cohorts. We identified 82 independent genome-wide significant variants within 76 loci, 41 of w…
View article: Correction: WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis
Correction: WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis Open
View article: The Role of <scp>SLC39A8</scp> .p.( <scp>Ala391Thr</scp> ) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General <scp>UK</scp> Population
The Role of <span>SLC39A8</span> .p.( <span>Ala391Thr</span> ) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General <span>UK</span> Population Open
The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide ass…
View article: Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder
Genome-wide meta-analysis identifies genetic risk factors and implicates multiple body systems in panic attacks and disorder Open
Introductory paragraph Panic attacks, sudden episodes of intense fear accompanied by physical and psychological symptoms, affect approximately 23% of the population 1,2 . Panic disorder, diagnosed in 2– 4% 3 , involves recurrent attacks fo…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study
Genetic overlap between functional impairment and depression and anxiety symptom severity: Evidence from the GLAD Study Open
Background Functional impairment in daily activities, such as work and socialising, is part of the diagnostic criteria for major depressive disorder (MDD) and most anxiety disorders. Despite evidence that symptom severity and functional im…
View article: Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank
Neurodevelopmental copy number variants increase risk of internalising and cardiometabolic multimorbidity: findings from UK Biobank Open
Background Internalising and cardiometabolic multimorbidity (ICM-MM) represents a major clinical challenge, negatively impacting life expectancy and quality of life and resulting in considerable healthcare costs. Individuals with a copy nu…
View article: Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia
Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia Open
View article: Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK
Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK Open
View article: Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank
Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in the UK Biobank Open
Background Mood and anxiety disorders co-occur and share symptoms, treatments and genetic risk, but it is unclear whether combining them into a single phenotype would better capture genetic variation. The contribution of common genetic var…
View article: Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans
Depression Genetics in Africa (DepGenAfrica): protocol for the first large-scale case-control study of major depressive disorder among continental Africans Open
BACKGROUND: Major Depressive Disorder (MDD) is a disabling condition that arises from the interplay of genetic and environmental risk factors. Most genetic studies of depression to date have failed to include continental African population…
View article: Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data
Recommendations for defining treatment outcomes in major psychiatric disorders leveraging real-world data Open
While information from real-world data (RWD) can be utilized to identify factors able to aid treatment choice, guidelines for the use of RWD are lacking. The aim of this narrative review and expert opinion is to summarize and evaluate defi…