Matthew Rickman
YOU?
Author Swipe
View article: Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial
Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial Open
Background Short-term studies suggest that dietary nitrate (NO 3 − ) supplementation may improve the cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial effects …
View article: T1 Alterations in vasoconstrictor biomarkers persist up to a year post-COVID-19 and are associated with pulmonary pathology
T1 Alterations in vasoconstrictor biomarkers persist up to a year post-COVID-19 and are associated with pulmonary pathology Open
Introduction Persistent respiratory disease and endothelial dysfunction are recognised complications of severe COVID-19 infection. Using data from the PROSAIC-19 study, we explored whether alterations in vasoconstrictor biomarkers persist …
Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway Open
Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was high…
Frizzled-4 regulates β-catenin in endothelial cells exposed to disturbed flow via an atypical Wnt pathway leading to proinflammatory activation and increased permeability Open
Objective Endothelial cells are regulated by hemodynamic wall shear stress and multidirectional shear stress is known to promote endothelial dysfunction, although the molecular mechanisms are poorly defined. Wnt pathways play an important …
A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits Open
The small EDRK-rich factor 2 (SERF2) is a highly conserved protein that modifies amyloid fibre assembly in vitro and promotes protein misfolding. However, the role of SERF2 in regulating age-related proteotoxicity remains largely unexplore…
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease Open
Background: Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a transgenic mouse involves random integration of exogenous DNA into the host genome that c…
View article: Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of <i>APP</i>
Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of <i>APP</i> Open
Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease. Worldwide approximately 6 million people have Down syndrome, and all these individuals will develop the hallmark …
The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease Open
Background: Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a transgenic mouse involves random integration of exogenous DNA into the host genome that c…
View article: [P2–141]: TRISOMY 21 CAUSES A DEFICIT IN LYSOSOMAL CATHEPSINS AND ALTERS APP/Aβ PROCESSING, INDEPENDENTLY OF AN EXTRA COPY OF <i>APP</i>
[P2–141]: TRISOMY 21 CAUSES A DEFICIT IN LYSOSOMAL CATHEPSINS AND ALTERS APP/Aβ PROCESSING, INDEPENDENTLY OF AN EXTRA COPY OF <i>APP</i> Open
Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and increases the risk of Alzheimer disease (AD). People who have DS universally develop AD pathology by the age of 40 and the majority develop early-onset dementia (AD-DS). …