Matthew S. Brown
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View article: Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer
Automated radiosynthesis of [18F]fluoromannitol for clinical research on a commercially available trasis allinone radiosynthesizer Open
An automated method for the radiochemical synthesis of [18F]fluoromannitol was developed and optimized on a commercially available Trasis AllinOne radiosynthesizer. This method allows for the reliable production and global disse…
View article: Automated Radiosynthesis of [18F]Fluoromannitol for Clinical Research on a Commercially Available Trasis AllinOne Radiosynthesizer
Automated Radiosynthesis of [18F]Fluoromannitol for Clinical Research on a Commercially Available Trasis AllinOne Radiosynthesizer Open
Background : Infections pose a significant risk to immunocompromised individuals, and accurate, efficient diagnosis remain challenging. Current imaging methods like MRI and FDG PET lack pathogen specificity which complicate diagnosis and l…
View article: Minimum clinically important difference in Quantitative Lung Fibrosis score associated with all-cause mortality in idiopathic pulmonary fibrosis: subanalysis from two phase II trials of pamrevlumab
Minimum clinically important difference in Quantitative Lung Fibrosis score associated with all-cause mortality in idiopathic pulmonary fibrosis: subanalysis from two phase II trials of pamrevlumab Open
Objectives Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease. Chest high-resolution CT (HRCT) is instrumental in IPF management, and the Quantitative Lung Fibrosis (QLF) score is a computer-assisted metric for …
View article: A comparative analysis of image harmonization techniques in mitigating differences in CT acquisition and reconstruction
A comparative analysis of image harmonization techniques in mitigating differences in CT acquisition and reconstruction Open
Objective . The study aims to systematically characterize the effect of CT parameter variations on images and lung radiomic and deep features, and to evaluate the ability of different image harmonization methods to mitigate the observed va…
View article: Assessing variability in non-contrast CT for the evaluation of stroke: the effect of CT image reconstruction conditions on AI-based CAD measurements of ASPECTS value and hypodense volume
Assessing variability in non-contrast CT for the evaluation of stroke: the effect of CT image reconstruction conditions on AI-based CAD measurements of ASPECTS value and hypodense volume Open
Automated ASPECTS and hypodense volume measurements can be significantly impacted by reconstruction kernel and slice thickness.
View article: Quantitative Computed Tomography Lung COVID Scores with Laboratory Markers: Utilization to Predict Rapid Progression and Monitor Longitudinal Changes in Patients with Coronavirus 2019 (COVID-19) Pneumonia
Quantitative Computed Tomography Lung COVID Scores with Laboratory Markers: Utilization to Predict Rapid Progression and Monitor Longitudinal Changes in Patients with Coronavirus 2019 (COVID-19) Pneumonia Open
Coronavirus disease 2019 (COVID-19), is an ongoing issue in certain populations, presenting rapidly worsening pneumonia and persistent symptoms. This study aimed to test the predictability of rapid progression using radiographic scores and…
View article: Pretreatment visceral metastases in castration resistant metastatic prostate cancer: role in prediction versus actual site of disease progression
Pretreatment visceral metastases in castration resistant metastatic prostate cancer: role in prediction versus actual site of disease progression Open
View article: The Forgotten Margins of AI Ethics
The Forgotten Margins of AI Ethics Open
How has recent AI Ethics literature addressed topics such as fairness and justice in the context of continued social and structural power asymmetries? We trace both the historical roots and current landmark work that have been shaping the …
View article: Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors
Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors Open
Imaging response assessment is a cornerstone of patient care and drug development in oncology. Clinicians/clinical researchers rely on tumor imaging to estimate the impact of new treatments and guide decision making for patients and candid…
View article: Orthodontists' perceptions of and adaptations to nonspecialist and direct-to-consumer orthodontic service providers
Orthodontists' perceptions of and adaptations to nonspecialist and direct-to-consumer orthodontic service providers Open
Objectives To evaluate orthodontists' perceived impacts on their practices as a result of general practitioners (GPs) and direct-to-consumer (DTC) orthodontic care providers and the adaptational changes implemented in the past 10 years. Ma…
View article: Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial
Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial Open
Rationale The long-acting β 2 -agonist/long-acting muscarinic antagonist combination indacaterol/glycopyrronium (IND/GLY) elicits bronchodilation, improves symptoms, and reduces exacerbations in COPD. Magnetic resonance imaging (MRI) of th…
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Contents Open
View article: Additional file 1 of Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial
Additional file 1 of Effect of indacaterol/glycopyrronium on ventilation and perfusion in COPD: a randomized trial Open
Additional file 1: Online data supplement and supplementary videos.
View article: Developing 2D and 3D Deep Learning-Based Models for an Automated Diagnosis of Idiopathic Pulmonary Fibrosis (IPF) Using Chest CT Scans
Developing 2D and 3D Deep Learning-Based Models for an Automated Diagnosis of Idiopathic Pulmonary Fibrosis (IPF) Using Chest CT Scans Open
RATIONALE Distinguishing idiopathic pulmonary fibrosis (IPF) among non-IPF interstitial lung disease (ILD) subjects is an important, but challenging task.Making a correct from a single HRCT study will be helpful to identify patients for ea…
View article: Reproducibility of lung nodule radiomic features: Multivariable and univariable investigations that account for interactions between CT acquisition and reconstruction parameters
Reproducibility of lung nodule radiomic features: Multivariable and univariable investigations that account for interactions between CT acquisition and reconstruction parameters Open
Purpose Recent studies have demonstrated a lack of reproducibility of radiomic features in response to variations in CT parameters. In addition, reproducibility of radiomic features has not been well established in clinical datasets. We ai…
View article: Radiographic read paradigms and the roles of the central imaging laboratory in neuro-oncology clinical trials
Radiographic read paradigms and the roles of the central imaging laboratory in neuro-oncology clinical trials Open
Determination of therapeutic benefit in intracranial tumors is intimately dependent on serial assessment of radiographic images. The Response Assessment in Neuro-Oncology (RANO) criteria were established in 2010 to provide an updated frame…
View article: Collection and Monitoring via Planning for Active Situational Scenarios (COMPASS) (Strategic Multi-Layer Assessment Report)
Collection and Monitoring via Planning for Active Situational Scenarios (COMPASS) (Strategic Multi-Layer Assessment Report) Open
An emergent type of geopolitical warfare in recent years has been coined "Gray Zone competition," "competition short of armed conflict", or simply "competition," because it sits in a nebulous area between peace and conventional conflict. A…
View article: Ethics, Privacy and Data Collection: A Complex Intersection
Ethics, Privacy and Data Collection: A Complex Intersection Open
The technology around us enables incredible abilities such as high-resolution video calls and the ability to stay connected with everyone we care about through social media. This technology also comes with a hidden cost in the form of data…
View article: Correction to: Toward clinically usable CAD for lung cancer screening with computed tomography
Correction to: Toward clinically usable CAD for lung cancer screening with computed tomography Open
View article: Using Transitional Changes on High‐Resolution Computed Tomography to Monitor the Impact of Cyclophosphamide or Mycophenolate Mofetil on Systemic Sclerosis–Related Interstitial Lung Disease
Using Transitional Changes on High‐Resolution Computed Tomography to Monitor the Impact of Cyclophosphamide or Mycophenolate Mofetil on Systemic Sclerosis–Related Interstitial Lung Disease Open
Objective To examine changes in the extent of specific patterns of interstitial lung disease ( ILD ) as they transition from one pattern to another in response to immunosuppressive therapy in systemic sclerosis–related ILD ( SS c‐ ILD ). M…
View article: The INTEGRITY Trial: Preservation of Uterine-Wall Integrity 12 Months After Transcervical Fibroid Ablation with the Sonata System
The INTEGRITY Trial: Preservation of Uterine-Wall Integrity 12 Months After Transcervical Fibroid Ablation with the Sonata System Open
Objective: The aim of this research was to evaluate uterine-wall integrity 12 months after transcervical fibroid ablation (TFA) of uterine fibroids with the Sonata® system (Gynesonics Inc., Redwood City, CA).
View article: Technical Note: Design and implementation of a high‐throughput pipeline for reconstruction and quantitative analysis of CT image data
Technical Note: Design and implementation of a high‐throughput pipeline for reconstruction and quantitative analysis of CT image data Open
Purpose With recent substantial improvements in modern computing, interest in quantitative imaging with CT has seen a dramatic increase. As a result, the need to both create and analyze large, high‐quality datasets of clinical studies has …
View article: Building a high-resolution T2-weighted MR-based probabilistic model of tumor occurrence in the prostate
Building a high-resolution T2-weighted MR-based probabilistic model of tumor occurrence in the prostate Open
View article: Quantitative bone scan lesion area as an early surrogate outcome measure indicative of overall survival in metastatic prostate cancer
Quantitative bone scan lesion area as an early surrogate outcome measure indicative of overall survival in metastatic prostate cancer Open
A clinical validation of the bone scan lesion area (BSLA) as a quantitative imaging biomarker was performed in metastatic castration-resistant prostate cancer (mCRPC). BSLA was computed from whole-body bone scintigraphy at baseline and wee…
View article: The effect of radiation dose reduction on computer-aided detection (CAD) performance in a low-dose lung cancer screening population
The effect of radiation dose reduction on computer-aided detection (CAD) performance in a low-dose lung cancer screening population Open
CAD sensitivity decreased very slightly for larger nodules as dose was reduced, indicating that reducing the dose to 50% of original levels may be investigated further for use in CT screening. However, the effect of dose was small relative…
View article: Prediction of IPF with the Early Changes in Quantitative Imaging Patterns Using High Resolution Computed Tomography
Prediction of IPF with the Early Changes in Quantitative Imaging Patterns Using High Resolution Computed Tomography Open
View article: P014 <break /> Quantitative CT as an Outcome Measure in the Scleroderma Lung Study II
P014 Quantitative CT as an Outcome Measure in the Scleroderma Lung Study II Open
View article: Introducing the Head-Mounted Rotating Drum
Introducing the Head-Mounted Rotating Drum Open
The rotating drum is a classic apparatus used to study circular vection – the visually induced illusion of self-rotation in a stationary observer. The observer sits in a large cylinder that has an illuminated interior, consisting of black …
View article: Variability in CT lung-nodule quantification: Effects of dose reduction and reconstruction methods on density and texture based features
Variability in CT lung-nodule quantification: Effects of dose reduction and reconstruction methods on density and texture based features Open
As expected, the histogram mean is the most robust feature in their study. The effects of acquisition and reconstruction conditions on GLCM features vary widely, though trending toward features involving summation of product between intens…
View article: Efficacy of MR-guided focused ultrasound ablation for localized adenomyosis in comparison to leiomyoma
Efficacy of MR-guided focused ultrasound ablation for localized adenomyosis in comparison to leiomyoma Open
Symptomatic localized adenomyosis is generally treated conservatively, or with more radical treatments such as hysterectomy. An effective non-invasive therapy is needed, especially for those who wish to preserve their fertility. MR-guided …