Matthew S. Faber
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View article: 1081 MICA/BxCD3 bispecific antibodies with integrated immunomodulatory activity
1081 MICA/BxCD3 bispecific antibodies with integrated immunomodulatory activity Open
View article: 1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers
1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers Open
Background Tumor microenvironment induced antigens present a unique opportunity to effectively target diseased tissue over normal and to modulate the immune suppression they might elicit. MICA and MICB (MICA/B) are stress-induced antigens …
View article: 1067 Synergistic combination of natural killer cell engagers (NKEs) with proinflammatory cytokines
1067 Synergistic combination of natural killer cell engagers (NKEs) with proinflammatory cytokines Open
Background While promoting antigen-dependent T cell responses has proven successful in a subset of patients and in certain tumors, the emergence of resistance and tumor heterogeneity with respect to MHC class I expression suggests addition…
View article: 787 Natural killer cell engagers activate innate and adaptive immunity and show synergy with proinflammatory cytokines
787 Natural killer cell engagers activate innate and adaptive immunity and show synergy with proinflammatory cytokines Open
Background Natural Killer cell Engagers (NKEs) are multifunctional molecules that target activating receptors on the surface of NK cells, bind to tumor associated antigens and engage Fc gamma receptors expressed on effector cells of the im…
View article: Saturation Mutagenesis Genome Engineering of Infective ΦX174 Bacteriophage <i>via</i> Unamplified Oligo Pools and Golden Gate Assembly
Saturation Mutagenesis Genome Engineering of Infective ΦX174 Bacteriophage <i>via</i> Unamplified Oligo Pools and Golden Gate Assembly Open
Here we present a novel protocol for the construction of saturation single-site-and massive multisite-mutant libraries of a bacteriophage. We segmented the ΦX174 genome into 14 nontoxic and nonreplicative fragments compatible with Golden G…
View article: Saturation mutagenesis genome engineering of infective ΦX174 bacteriophage via unamplified oligo pools and golden gate assembly
Saturation mutagenesis genome engineering of infective ΦX174 bacteriophage via unamplified oligo pools and golden gate assembly Open
Here we present a novel protocol for the construction of saturation single-site—and massive multi-site—mutant libraries of a bacteriophage. We segmented the ΦX174 genome into 14 non-toxic and non-replicative fragments compatible with golde…
View article: Impact of In Vivo Protein Folding Probability on Local Fitness Landscapes
Impact of In Vivo Protein Folding Probability on Local Fitness Landscapes Open
It is incompletely understood how biophysical properties like protein stability impact molecular evolution and epistasis. Epistasis is defined as specific when a mutation exclusively influences the phenotypic effect of another mutation, of…
View article: User-defined single pot mutagenesis using unamplified oligo pools
User-defined single pot mutagenesis using unamplified oligo pools Open
User-defined mutagenic libraries are fundamental for applied protein engineering workflows. Here we show that unamplified oligo pools can be used to prepare site saturation mutagenesis libraries from plasmid DNA with near-complete coverage…
View article: Deep sequencing methods for protein engineering and design
Deep sequencing methods for protein engineering and design Open
View article: Metallic CoS<sub>2</sub> nanowire electrodes for high cycling performance supercapacitors
Metallic CoS<sub>2</sub> nanowire electrodes for high cycling performance supercapacitors Open
We report metallic cobalt pyrite (CoS2) nanowires (NWs) prepared directly on current collecting electrodes, e.g., carbon cloth or graphite disc, for high-performance supercapacitors. These CoS2 NWs have a variety of advantages for supercap…
View article: Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing
Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing Open
Knowledge of the fine location of neutralizing and non-neutralizing epitopes on human pathogens affords a better understanding of the structural basis of antibody efficacy, which will expedite rational design of vaccines, prophylactics, an…
View article: Amorphous MoS<sub>x</sub>Cl<sub>y</sub> electrocatalyst supported by vertical graphene for efficient electrochemical and photoelectrochemical hydrogen generation
Amorphous MoS<sub>x</sub>Cl<sub>y</sub> electrocatalyst supported by vertical graphene for efficient electrochemical and photoelectrochemical hydrogen generation Open
Amorphous MoSxCly electrocatalyst on vertical graphene shows high catalytic performance for electrochemical and photoelectrochemical hydrogen generation.