Matthew S. Jung
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View article: The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling
The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling Open
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key regulator of cancer stem cell (CSC) biology and signaling. In CSCs, ROR1 acts as a receptor or co-receptor, interacting with non-canonical WNT ligands, and forming complexes w…
View article: IL-17 signaling protects against <i>Helicobacter pylori-</i> induced gastric cancer
IL-17 signaling protects against <i>Helicobacter pylori-</i> induced gastric cancer Open
Helicobacter pylori infection is the predominant risk factor for the development of gastric cancer. Risk is enhanced by specific H. pylori virulence factors, diet, and the inflammatory response. Chronic activation of T helper…
View article: IL-17RA–Mediated Epithelial Cell Activity Prevents Severe Inflammatory Response to <i>Helicobacter pylori</i> Infection
IL-17RA–Mediated Epithelial Cell Activity Prevents Severe Inflammatory Response to <i>Helicobacter pylori</i> Infection Open
Helicobacter pylori is a Gram-negative pathogen that colonizes the stomach, induces inflammation, and drives pathological changes in the stomach tissue, including gastric cancer. As the principal cytokine produced by Th17 cells, IL-17 medi…
View article: Essential role of <i>Helicobacter pylori</i> apolipoprotein N-acyltransferase (Lnt) in stomach colonization
Essential role of <i>Helicobacter pylori</i> apolipoprotein N-acyltransferase (Lnt) in stomach colonization Open
Bacterial lipoproteins are post-translationally modified with acyl chains, anchoring these proteins to bacterial membranes. In Gram-negative bacteria, three enzymes complete the modifications. Lgt (which adds two acyl chains) and LspA (whi…
View article: IL-17 Receptor A protects against <i>Helicobacter pylori-</i> induced gastric cancer
IL-17 Receptor A protects against <i>Helicobacter pylori-</i> induced gastric cancer Open
Infection with Helicobacter pylori is the predominant risk factor for the development of gastric cancer. Risk is enhanced by specific H. pylori virulence factors, diet, and the inflammatory response. Chronic activation of T helper (Th) 1 a…