Matthew T. Richers
YOU?
Author Swipe
View article: Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission
Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission Open
We have developed photochromic probes for the nicotinic acetylcholine receptor that exploit the unique chemical properties of the tetrafluoroazobenzene (4FAB) scaffold. Ultraviolet light switching and rapid thermal relaxation of the metast…
View article: Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π‐Electron Caging Chromophore
Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π‐Electron Caging Chromophore Open
We have developed a caged neurotransmitter using an extended π‐electron chromophore for efficient multiphoton uncaging on living neurons. Widely studied in a chemical context, such chromophores are inherently bioincompatible due to their h…
View article: Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue
Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue Open
Key points A new caged nicotinic acetylcholine receptor (nAChR) agonist was developed, ABT594, which is photolysed by one‐ and two‐photon excitation. The caged compound is photolysed with a quantum yield of 0.20. One‐photon uncaging of ABT…
View article: Thermodynamically Stable, Photoreversible Pharmacology in Neurons with One‐ and Two‐Photon Excitation
Thermodynamically Stable, Photoreversible Pharmacology in Neurons with One‐ and Two‐Photon Excitation Open
Photoswitchable bioprobes enable bidirectional control of cell physiology with different wavelengths of light. Many current photoswitches use cytotoxic UV light and are limited by the need for constant illumination owing to thermal relaxat…
View article: Coumarin-diene photoswitches for rapid and efficient isomerization with visible light
Coumarin-diene photoswitches for rapid and efficient isomerization with visible light Open
Coumarin-dienyl chromophores undergo rapid, fatigue-resistant bi-directional photoswitching with visible light.
View article: Two-color, one-photon uncaging of glutamate and GABA
Two-color, one-photon uncaging of glutamate and GABA Open
Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction between excitatory and inhibitory receptors with exogenously applied transmitters in t…
View article: Cloaked Caged Compounds: Chemical Probes for Two‐Photon Optoneurobiology
Cloaked Caged Compounds: Chemical Probes for Two‐Photon Optoneurobiology Open
Caged neurotransmitters, in combination with focused light beams, enable precise interrogation of neuronal function, even at the level of single synapses. However, most caged transmitters are, surprisingly, severe antagonists of ionotropic…
View article: Development of Anionically Decorated Caged Neurotransmitters: In Vitro Comparison of 7‐Nitroindolinyl‐ and 2‐(<i>p</i>‐Phenyl‐<i>o</i>‐nitrophenyl)propyl‐Based Photochemical Probes
Development of Anionically Decorated Caged Neurotransmitters: In Vitro Comparison of 7‐Nitroindolinyl‐ and 2‐(<i>p</i>‐Phenyl‐<i>o</i>‐nitrophenyl)propyl‐Based Photochemical Probes Open
Neurotransmitter uncaging, especially that of glutamate, has been used to study synaptic function for over 30 years. One limitation of caged glutamate probes is the blockade of γ‐aminobutyric acid (GABA)‐A receptor function. This problem c…
View article: C–H functionalization of cyclic amines: redox-annulations with α,β-unsaturated carbonyl compounds
C–H functionalization of cyclic amines: redox-annulations with α,β-unsaturated carbonyl compounds Open
Pyrrolidine and related amines undergo carboxylic acid promoted redox-annulations with α,β-unsaturated ketonesviathe intermediacy of conjugated azomethine ylides.
View article: CCDC 1061074: Experimental Crystal Structure Determination
CCDC 1061074: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1061075: Experimental Crystal Structure Determination
CCDC 1061075: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of amine alpha-functionalizations involving azomethine ylides intermediates
Development of amine alpha-functionalizations involving azomethine ylides intermediates Open
The α-functionalization of amines is a synthetic challenge of much interest to organic chemists. Common methods involve deprotonation with strong bases or oxidation with stoichiometric oxidants or transition metal catalysts. An alternative…