Matthew W. Elmes
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View article: CCDC 1983862: Experimental Crystal Structure Determination
CCDC 1983862: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-Based Screening
Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-Based Screening Open
[Image: see text] Fatty acid binding protein 5 (FABP5) is a promising target for development of inhibitors to help control pain and inflammation. In this work, computer-based docking (DOCK6 program) was employed to screen ∼2 M commercially…
View article: Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation
Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation Open
(-)-Incarvillateine (INCA) is a natural product that has garnered attention due to its purported analgesic effects and historical use as a pain reliever in China. α-Truxillic acid monoesters (TAMEs) constitute a class of inhibitors targeti…
View article: FABP1 controls hepatic transport and biotransformation of Δ9-THC
FABP1 controls hepatic transport and biotransformation of Δ9-THC Open
View article: SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins
SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins Open
View article: Author Index
Author Index Open
View article: Fatty-acid–binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses
Fatty-acid–binding protein 5 controls retrograde endocannabinoid signaling at central glutamate synapses Open
Significance Endocannabinoids (eCBs), a family of active lipids, modulate synaptic transmission in the brain. Research conducted over the past decades has delineated the mechanisms by which eCBs control synaptic function. However, how thes…
View article: Fatty acid–binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation
Fatty acid–binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation Open
Fatty acid-binding proteins (FABPs) are intracellular lipid carriers that regulate inflammation, and pharmacological inhibition of FABP5 reduces inflammation and pain. The mechanism(s) underlying the anti-inflammatory effects associated wi…
View article: The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites
The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites Open
Human FABP5 and FABP7 are intracellular endocannabinoid transporters. SBFI-26 is an α-truxillic acid 1-naphthyl monoester that competitively inhibits the activities of FABP5 and FABP7 and produces antinociceptive and anti-inflammatory effe…
View article: Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms
Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms Open
Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of…
View article: Author Index
Author Index Open
View article: Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
Fatty Acid-binding Proteins (FABPs) Are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) Open
Δ(9)-Tetrahydrocannabinol (THC) and cannabidiol (CBD) occur naturally in marijuana (Cannabis) and may be formulated, individually or in combination in pharmaceuticals such as Marinol or Sativex. Although it is known that these hydrophobic …