Matthew W. Hulver
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View article: MYC and Epithelial to Mesenchymal Transition (EMT) Independently Predict Circadian Rhythm Disruption in Lung Adenocarcinoma
MYC and Epithelial to Mesenchymal Transition (EMT) Independently Predict Circadian Rhythm Disruption in Lung Adenocarcinoma Open
The molecular circadian clock is known to be disrupted in lung adenocarcinoma, and its disruption is pro-tumorigenic in mouse models of this disease. However, the determinants of disruption of the molecular clock in human cancer are not cl…
View article: Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues
Adropin expression reflects circadian, lipoprotein, and mitochondrial processes in human tissues Open
View article: Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial
Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial Open
Prediabetes affects 84.1 million adults, and many will progress to type 2 diabetes (T2D). The objective of this proof-of-concept trial was to determine the efficacy of inulin supplementation to improve glucose metabolism and reduce T2D ris…
View article: Fasting and postprandial trimethylamine <i>N</i> ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet
Fasting and postprandial trimethylamine <i>N</i> ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet Open
Gut bacteria release trimethylamine (TMA) from dietary substrates. TMA is absorbed and is subsequently oxidized in the liver to produce trimethylamine N-oxide (TMAO). Plasma TMAO levels are positively correlated with risk for type 2 diabet…
View article: Heat Stress Reduces Metabolic Rate While Increasing Respiratory Exchange Ratio in Growing Pigs
Heat Stress Reduces Metabolic Rate While Increasing Respiratory Exchange Ratio in Growing Pigs Open
Heat stress (HS) diminishes animal production, reducing muscle growth and increasing adiposity, especially in swine. Excess heat creates a metabolic phenotype with limited lipid oxidation that relies on aerobic and anaerobic glycolysis as …
View article: Nox4 mediates skeletal muscle metabolic responses to exercise
Nox4 mediates skeletal muscle metabolic responses to exercise Open
We report that H2O2 and Nox4 promote immediate responses to exercise in skeletal muscle. Glucose and fatty acid oxidation were blunted in the Nox4-deficient mice post-exercise, potentially through regulation of UCP3 e…
View article: Overfeeding and Substrate Availability, But Not Age or BMI, Alter Human Satellite Cell Function
Overfeeding and Substrate Availability, But Not Age or BMI, Alter Human Satellite Cell Function Open
Satellite cells (SC) aid skeletal muscle growth and regeneration. SC-mediated skeletal muscle repair can both be influenced by and exacerbate several diseases linked to a fatty diet, obesity, and aging. The purpose of this study was to eva…
View article: Patterns of Clinical Care Subsequent to Nonindicated Vitamin D Testing in Primary Care
Patterns of Clinical Care Subsequent to Nonindicated Vitamin D Testing in Primary Care Open
Evidence of a health service cascade following nonindicated vitamin D testing exists. Opportunities for improved consistency and quality of care related to vitamin D were observed in our health system. These results may inform clinical pat…
View article: Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis
Dietary and Biological Assessment of the Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis Open
Omega-3 fatty acids (ω-3 FA) are associated with cardiovascular health, brain function, reduction of inflammation, and several other physiological roles of importance to competitive athletes. The ω-3 FA status of National Collegiate Athlet…
View article: Postprandial skeletal muscle metabolism following a high-fat diet in sedentary and endurance-trained males
Postprandial skeletal muscle metabolism following a high-fat diet in sedentary and endurance-trained males Open
Our objective was to determine the influence of a high-fat diet (HFD) on fasting and postprandial skeletal muscle substrate metabolism in endurance-trained (ET) compared with sedentary (SED) humans. SED ( n = 17) and ET ( n = 7) males were…
View article: Dietary and Biological Assessment of Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis
Dietary and Biological Assessment of Omega-3 Status of Collegiate Athletes: A Cross-Sectional Analysis Open
Omega-3 fatty acids (ω-3 FA) play a number of important functions in health and human performance. While previous research has suggested that low ω-3 FA status is prevalent in the general population, little information about athletes’ ω-3 …
View article: Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans
Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans Open
View article: Vitamin D Practice Patterns in National Collegiate Athletic Association Division I Collegiate Athletics Programs
Vitamin D Practice Patterns in National Collegiate Athletic Association Division I Collegiate Athletics Programs Open
Context Vitamin D status has been associated with performance, health, and well-being in athletic populations. The measurement of vitamin D status via 25-hydroxyvitamin D [25(OH)D] testing has increased in the general population, as has vi…
View article: Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus
Selective Histone Deacetylase 6 Inhibition Normalizes B Cell Activation and Germinal Center Formation in a Model of Systemic Lupus Erythematosus Open
Autoantibody production by plasma cells (PCs) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). The molecular pathways by which B cells become pathogenic PC secreting autoantibodies in SLE are incompletely cha…
View article: Implementation of Blood Flow Restriction for Injury Rehabilitation in the Athletic Training Setting
Implementation of Blood Flow Restriction for Injury Rehabilitation in the Athletic Training Setting Open
Rehabilitation after an injury in athletics is a major concern for athletes and athletic trainers. The athletic trainer is responsible for returning the injured athlete back to participation as fast and safely as possible. Since it is typi…
View article: Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism Open
View article: Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs
Heat stress decreases metabolic flexibility in skeletal muscle of growing pigs Open
Heat-stressed pigs experience metabolic alterations, including altered insulin profiles, reduced lipid mobilization, and compromised intestinal integrity. This is bioenergetically distinct from thermal neutral pigs on a similar nutritional…
View article: Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes
Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes Open
Trimethylamine N-oxide (TMAO) is associated with type 2 diabetes (T2DM) and increased risk of adverse cardiovascular events. Prebiotic supplementation has been purported to reduce TMAO production, but whether prebiotics reduce fasting or p…
View article: Clinical Management of Low Vitamin D: A Scoping Review of Physicians’ Practices
Clinical Management of Low Vitamin D: A Scoping Review of Physicians’ Practices Open
The role of vitamin D in the prevention and treatment of non-skeletal health issues has received significant media and research attention in recent years. Costs associated with clinical management of low vitamin D (LVD) have increased expo…
View article: Clinical Management of Low Vitamin D: A Scoping Review of Physician Practices
Clinical Management of Low Vitamin D: A Scoping Review of Physician Practices Open
The role of vitamin D in the prevention and treatment of non-skeletal health issues has received significant media and research attention in recent years. Costs associated with clinical management of low vitamin D (LVD) have increased expo…
View article: Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity
Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity Open
Elevated muscle O-GlcNAc levels paralleled insulin resistance and type 2 diabetes in humans. Moreover, OGT-mediated signaling is necessary for proper skeletal muscle metabolism and whole-body energy homeostasis, and our data highlight O-Gl…
View article: Effects of heat stress during porcine reproductive and respiratory syndrome virus infection on metabolic responses in growing pigs
Effects of heat stress during porcine reproductive and respiratory syndrome virus infection on metabolic responses in growing pigs Open
Heat stress (HS) and immune challenges negatively impact nutrient allocation and metabolism in swine, especially due to elevated heat load. In order to assess the effects of HS during Porcine Reproductive and Respiratory Syndrome Virus (PR…
View article: Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal
Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal Open
In summary, mitophagy may be enhanced in endurance-trained runners based on elevated markers of mitophagy and mitochondrial dynamics. The HFM did not alter autophagy or mitophagy in either group. The absence of a relationship between mitop…
View article: NLRX1 Regulates Effector and Metabolic Functions of CD4+ T Cells
NLRX1 Regulates Effector and Metabolic Functions of CD4+ T Cells Open
Nucleotide oligomerization domain–like receptor X1 (NLRX1) has been implicated in viral response, cancer progression, and inflammatory disorders; however, its role as a dual modulator of CD4+ T cell function and metabolism has not been def…
View article: Acute low-dose endotoxin treatment results in improved whole-body glucose homeostasis in mice
Acute low-dose endotoxin treatment results in improved whole-body glucose homeostasis in mice Open
View article: Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens
Fasting rapidly increases fatty acid oxidation in white adipose tissue of young broiler chickens Open
Upregulating the fatty acid oxidation capacity of white adipose tissue in mice protects against diet-induced obesity, inflammation and insulin resistance. Part of this capacity results from induction of brown-like adipocytes within classic…
View article: GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro
GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro Open
View article: Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults
Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults Open
Whether resistance exercise training (RET) improves skeletal muscle substrate oxidative capacity and reduces mitochondrial production of reactive oxygen species in older adults remains unclear. To address this, 19 older males (≥60 years) w…
View article: X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner
X-linked intellectual disability gene CASK regulates postnatal brain growth in a non-cell autonomous manner Open
View article: Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model
Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model Open
Acute oral administration of grape powder attenuates the hyperglycemic effects of GLP-1 receptor antagonism in rats.