Matthias Balk
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View article: A multimodal dataset for precision oncology in head and neck cancer
A multimodal dataset for precision oncology in head and neck cancer Open
View article: Endoscopic surgery versus various open approaches in esthesioneuroblastoma: a systematic review of the literature
Endoscopic surgery versus various open approaches in esthesioneuroblastoma: a systematic review of the literature Open
Objective Esthesioneuroblastoma (ENB) is treated using several open surgery (OpS) methods, with or without endoscopic assistance ( ± E-ass) or endoscopic surgery (ES). This systematic review compared the results with various approaches usi…
View article: Patient-reported outcomes in head and neck cancer: a cross-sectional analysis of quality of life domains across early and advanced UICC stages
Patient-reported outcomes in head and neck cancer: a cross-sectional analysis of quality of life domains across early and advanced UICC stages Open
Background Head and neck cancer (HNC) patients experience a variety of post-treatment symptoms that affect their quality of life (QoL). This study aims to assess the most prevalent symptoms and their relationship to cancer stage (UICC I–IV…
View article: Forty-Year Long-Term Outcome After Endoscopic and Open Surgery for Esthesioneuroblastoma in Consideration of Prognostic Factors
Forty-Year Long-Term Outcome After Endoscopic and Open Surgery for Esthesioneuroblastoma in Consideration of Prognostic Factors Open
Background: The objective of this study was to compare results after endoscopic (ES) and open surgery (OpS) for esthesioneuroblastoma over a 40-year period. Methods: In a retrospective study, patients who had undergone ES and OpS for esthe…
View article: Symptom Burden and Quality of Life in Long-Term Survivors with Head and Neck Cancer
Symptom Burden and Quality of Life in Long-Term Survivors with Head and Neck Cancer Open
Objectives: In this study, long-term survivors of head and neck cancer (HNC) were evaluated regarding their symptom burden and quality of life (QoL). Methods: This prospective study was performed during the regular follow-up consultations …
View article: Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas
Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas Open
Background We aimed to validate the prognostic significance of tumor budding (TB) in p16-positive oropharyngeal squamous cell carcinomas (OPSCC). Methods We analyzed digitized H&E-stained slides from a multicenter cohort of five large univ…
View article: Chronic hearing loss turns out being a calcified chondroid mesenchymal neoplasm with FN1::FGFR2 fusion
Chronic hearing loss turns out being a calcified chondroid mesenchymal neoplasm with FN1::FGFR2 fusion Open
View article: Postoperative pain after parotid surgery—comparison between superficial/total parotidectomy and extracapsular dissection: a prospective observational study
Postoperative pain after parotid surgery—comparison between superficial/total parotidectomy and extracapsular dissection: a prospective observational study Open
View article: Impact of Cancer Localization on Symptom Burden and Quality of Life in Head and Neck Cancers: A Comparative Study
Impact of Cancer Localization on Symptom Burden and Quality of Life in Head and Neck Cancers: A Comparative Study Open
Background: Head and neck cancer (HNC) is a critical concern in oncology, with notable disparities in survival rates. While the long-term symptom burden in HNC survivors and its impact on quality of life (QoL) has been explored, there is l…
View article: Defining intra-tumoral and systemic immune biomarkers for locally advanced head-and-neck cancer – detailed protocol of a prospective, observatory multicenter trial (ImmunBioKHT) and first results of the immunophenotyping of the patients’ peripheral blood
Defining intra-tumoral and systemic immune biomarkers for locally advanced head-and-neck cancer – detailed protocol of a prospective, observatory multicenter trial (ImmunBioKHT) and first results of the immunophenotyping of the patients’ peripheral blood Open
The approval and effectiveness of immune checkpoint inhibitors in head-and-neck squamous cell carcinoma (HNSCC) highlights the role of the immune system in this tumor entity. HNSCCs not only interacts with the immune system in the tumor ti…
View article: A multimodal dataset for precision oncology in head and neck cancer
A multimodal dataset for precision oncology in head and neck cancer Open
Head and neck cancer is a common disease and is associated with a poor prognosis. A promising approach to improving patient outcomes is personalized treatment, which uses information from a variety of modalities. However, only little progr…
View article: Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma
Exosomal Serum Biomarkers as Predictors for Laryngeal Carcinoma Open
Background: The lack of screening methods for LSCC is a critical issue, as treatment options and the treatment outcome greatly depend on the stage of LSCC at initial diagnosis. Therefore, the objective of this study was to identify potenti…
View article: A New Immortalized Human Lacrimal Gland Cell Line
A New Immortalized Human Lacrimal Gland Cell Line Open
The lacrimal gland is crucial for maintaining ocular health by producing the aqueous component of the tear film, which hydrates and nourishes the ocular surface. Decreased production of this component results in dry eye disease, a conditio…
View article: Case-tailored indicated extracapsular dissection versus “one-size-fits-all” nerve dissection: Has the bet been won?
Case-tailored indicated extracapsular dissection versus “one-size-fits-all” nerve dissection: Has the bet been won? Open
Our study showed that the increased performance of less radical surgery was associated with better functional outcomes over the years.
View article: Characterization of a new lacrimal gland cell line in 2D and 3D cell culture models
Characterization of a new lacrimal gland cell line in 2D and 3D cell culture models Open
The lacrimal gland produces the tear film’s aqueous component, which moistens and nourishes the ocular surface to maintain eye health. Reduced production of this component leads to dry eye disease, which affects over 250 million people wor…
View article: The modified <scp>Polsby–Popper</scp> score, a novel quantitative histomorphological biomarker and its potential to predict lymph node positivity and cancer‐specific survival in oral tongue squamous cell carcinoma
The modified <span>Polsby–Popper</span> score, a novel quantitative histomorphological biomarker and its potential to predict lymph node positivity and cancer‐specific survival in oral tongue squamous cell carcinoma Open
Background The significance of different histological spreading patterns of tumor tissue in oral tongue squamous cell carcinoma (TSCC) is well known. Our aim was to construct a numeric parameter on a continuous scale, that is, the modified…
View article: Surgical Versus Noninvasive Manual Repositioning After Cochlear Implant Partial Magnet Dislocation
Surgical Versus Noninvasive Manual Repositioning After Cochlear Implant Partial Magnet Dislocation Open
Objectives: To compare surgical magnet repositioning (SMR) and noninvasive manual magnet repositioning (MMR) as treatments for partial magnet dislocation (PMD) of the internal magnet in a cochlear implant (CI) caused by magnetic resonance …
View article: The Effects of a ‘New Generation’ of Heat and Moisture Exchangers in Laryngectomized Patients with Previous Heat and Moisture Exchanger Experience
The Effects of a ‘New Generation’ of Heat and Moisture Exchangers in Laryngectomized Patients with Previous Heat and Moisture Exchanger Experience Open
Objectives: To evaluate the effects of a new generation of heat and moisture exchangers (NG-HMEs) on pulmonary rehabilitation, quality of life, patient satisfaction, and usage patterns. Methods: A prospective observational study on 23 lary…
View article: Deep Learning and Registration-Based Mapping for Analyzing the Distribution of Nodal Metastases in Head and Neck Cancer Cohorts: Informing Optimal Radiotherapy Target Volume Design
Deep Learning and Registration-Based Mapping for Analyzing the Distribution of Nodal Metastases in Head and Neck Cancer Cohorts: Informing Optimal Radiotherapy Target Volume Design Open
We introduce a deep-learning- and a registration-based method for automatically analyzing the spatial distribution of nodal metastases (LNs) in head and neck (H/N) cancer cohorts to inform radiotherapy (RT) target volume design. The two me…
View article: A comparison between p16-positive head and neck cancer of unknown primary (HPV-HNCUP) and oropharyngeal squamous cell carcinoma (HPV-OPSCC): are they the same disease?
A comparison between p16-positive head and neck cancer of unknown primary (HPV-HNCUP) and oropharyngeal squamous cell carcinoma (HPV-OPSCC): are they the same disease? Open
View article: EAONO/JOS classification for acquired cholesteatoma: evaluating the impact of the number of affected sites on treatment and outcomes
EAONO/JOS classification for acquired cholesteatoma: evaluating the impact of the number of affected sites on treatment and outcomes Open
Purpose The European and Japanese system for cholesteatoma classification proposed an anatomical differentiation in five sites. In stage I disease, one site would be affected and in stage II, two to five. We tested the significance of this…
View article: Analgesia after tonsillectomy with controlled intravenous morphine – overdue or exaggerated?
Analgesia after tonsillectomy with controlled intravenous morphine – overdue or exaggerated? Open
Objective: To assess the value of a morphine Patient Controlled Intravenous Analgesia (PCIA) after Tonsillectomies (TE). Methods: 30 adult patients were treated with oral analgesics (protocol group) and compared to 30 patients treated with…
View article: Risk of magnetic resonance imaging-induced magnet dislocation for different types of cochlear implants: A single-center retrospective study
Risk of magnetic resonance imaging-induced magnet dislocation for different types of cochlear implants: A single-center retrospective study Open
Background When performing magnetic resonance imaging (MRI) in patients with a cochlear implant (CI), complication rates vary widely in the literature. The primary objective of this retrospective study was to determine the prevalence of co…
View article: Pain management after tonsillectomy—by demand or by-the-clock—is there a difference?
Pain management after tonsillectomy—by demand or by-the-clock—is there a difference? Open
Purpose To improve pain management after tonsillectomy (TE) by comparing individual analgesic management by demand versus a fixed-scheduled analgesic treatment protocol in a prospective trial. Patients and Methods Forty consecutive patient…
View article: Results of contralateral anastomosis of microvascular free flaps in head and neck reconstruction
Results of contralateral anastomosis of microvascular free flaps in head and neck reconstruction Open
Objectives Despite various solutions to the issue of ipsilateral vessel-depleted neck in microvascular head and neck reconstruction, concrete data on its safety and implementation are scarce. This paper focuses on the feasibility and succe…
View article: Systematic classification of confocal laser endomicroscopy for the diagnosis of oral cavity carcinoma
Systematic classification of confocal laser endomicroscopy for the diagnosis of oral cavity carcinoma Open
The results confirm that this scoring system is applicable in the oral cavity mucosa to classify benign and malignant tissue.
View article: Factors Influencing the Outcome of Head and Neck Cancer of Unknown Primary (HNCUP)
Factors Influencing the Outcome of Head and Neck Cancer of Unknown Primary (HNCUP) Open
Background: This study on patients with head and neck cancer of unknown primary (HNCUP) assesses the impact of surgical and non-surgical treatment modalities and the tumour biology on the oncological outcome. Methods: A total of 80 patient…
View article: Symptomlast ambulanter Patienten mit malignen Kopf-Hals-Tumoren
Symptomlast ambulanter Patienten mit malignen Kopf-Hals-Tumoren Open
Einführung Therapeutische Maßnahmen in der Kopf-Hals-Onkologie haben häufig negative Auswirkungen auf die Lebensqualität. In dieser monozentrischen, prospektiven Kohortenstudie untersuchten wir die Symptomlast von Patienten mit malignen Ko…
View article: U-Feder-Tympanoplastik bei anterioren und subtotalen Trommelfelldefekten – experimentelle Felsenbeinstudie und erste klinische Ergebnisse
U-Feder-Tympanoplastik bei anterioren und subtotalen Trommelfelldefekten – experimentelle Felsenbeinstudie und erste klinische Ergebnisse Open
Einleitung Kürzlich wurde die U-Feder-Tympanoplastik als neue Methode zur Rekonstruktion von anterioren und subtotalen Trommelfelldefekten bei chronischer Otitis media vorgestellt. Hierfür wird ein Underlay-Knorpeltransplantat mittels eine…
View article: Symptom burden of outpatients with malignant head and neck cancer
Symptom burden of outpatients with malignant head and neck cancer Open
Introduction Therapeutic interventions in head and neck oncology often have a negative impact on quality of life. In this monocentric, prospective cohort study, we investigated the symptom burden of patients with malignant head and neck ca…