Matthias Blüher
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View article: Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo
Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo Open
Altered activity of brown adipose tissue (BAT) contributes to obesity, insulin resistance, and cardiovascular disease. BAT secretes endocrine factors (“batokines”) that regulate thermogenesis. We identify the serpin vaspin as a batokine th…
View article: 13C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals
13C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals Open
Human exposure to certain environmental chemicals, including phthalates, is linked to metabolic disruption and may thereby contribute to diseases like obesity. However, regulatory methods to evaluate such effects are lacking. DINCH was int…
View article: Nutritional and lifestyle supportive care recommendations for management of obesity with GLP-1 - based therapies: An expert consensus statement using a modified Delphi approach
Nutritional and lifestyle supportive care recommendations for management of obesity with GLP-1 - based therapies: An expert consensus statement using a modified Delphi approach Open
View article: Effectiveness of an internet-based self-help intervention for improving mental health in individuals with obesity: study protocol for a randomised controlled trial
Effectiveness of an internet-based self-help intervention for improving mental health in individuals with obesity: study protocol for a randomised controlled trial Open
Introduction Patients with chronic somatic diseases such as obesity often develop comorbid depressive symptoms. E-mental health interventions are an innovative and effective treatment option within a stepped care approach. Studies have sho…
View article: A prospective cohort analysis from Germany shows transition into adulthood is an underestimated vulnerable period for children with overweight/obesity
A prospective cohort analysis from Germany shows transition into adulthood is an underestimated vulnerable period for children with overweight/obesity Open
View article: Secretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity
Secretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity Open
Obesity is a major driver of type 2 diabetes (T2D) and related metabolic disorders, characterized by chronic inflammation and adipocyte dysfunction. However, the molecular triggers initiating these processes remain poorly understood. We id…
View article: From model to man: Understanding Tregs' dual role in MASLD
From model to man: Understanding Tregs' dual role in MASLD Open
View article: Salivary extracellular vesicle-derived microRNAs are related to variances in parameters of obesity, taste and eating behaviour
Salivary extracellular vesicle-derived microRNAs are related to variances in parameters of obesity, taste and eating behaviour Open
This study, one of the largest on salivary EVs, supports an interrelation of EV's microRNA load with metabolism, eating behaviour and taste recognition offering potential targets for obesity intervention.
View article: MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes Open
View article: Prevention of type 2 diabetes through prediabetes remission without weight loss
Prevention of type 2 diabetes through prediabetes remission without weight loss Open
View article: Disease-Management-Programm Adipositas
Disease-Management-Programm Adipositas Open
View article: Cholinergic network modulation in disinhibited eating behavior
Cholinergic network modulation in disinhibited eating behavior Open
View article: Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome
Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome Open
Adipocyte hypertrophy during obesity triggers chronic inflammation, leading to metabolic disorders. However, the role of adipocyte-specific inflammatory signaling in metabolic syndrome remains unclear. The linear ubiquitin chain assembly c…
View article: Regulators of RNA m5C methylation are adipose tissue depot-specific expressed and correlate with clinical variables of obesity in humans
Regulators of RNA m5C methylation are adipose tissue depot-specific expressed and correlate with clinical variables of obesity in humans Open
Background Obesity is a global health burden and recent evidence indicates that epitranscriptomic regulation is potentially involved in its etiology. The epitranscriptomic mark 5-methylcytosine (m 5 C) is implicated in cancer and recent da…
View article: A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.
A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. Open
Cardiometabolic diseases (CMD) are on the rise globally with one billion people expected to suffer from obesity and 643 million from type 2 diabetes by 2030, of which one-third will likely develop chronic kidney disease and two-thirds will…
View article: Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation
Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation Open
Controlling brown adipose tissue (BAT) plasticity in adulthood holds promising potential for effective new obesity therapies by targeting the mechanisms of adaptive thermogenesis. Recent studies have shown that BAT development and function…
View article: Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial
Serum Galectin-9 and Decorin in relation to brain aging and the green-Mediterranean diet: A secondary analysis of the DIRECT PLUS randomized trial Open
NCT03020186.
View article: A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation
A DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation Open
View article: A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity Open
Altogether, we identified AZIN2 as a novel AP marker that regulates AP fate and preserves adipose tissue health.
View article: Reference Values for Serum Leptin Levels in Children, Adolescents, and Adults With Normal Weight, Overweight, and Obesity
Reference Values for Serum Leptin Levels in Children, Adolescents, and Adults With Normal Weight, Overweight, and Obesity Open
Background Interpretation of blood leptin concentration in clinical practice and research is limited by a lack of comprehensive reference values. We aimed to establish reference ranges across the age and weight spectrum, taking into consid…
View article: NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo
NRAC controls CD36-mediated fatty acid uptake in adipocytes and lipid clearance in vivo Open
Adipose tissue is a central organiser of systemic lipid homeostasis and a pharmacological target in obesity, orchestrating cellular responses to environmental cues. Nutritionally regulated adipose and cardiac enriched protein (NRAC) is a s…
View article: Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH
Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH Open
The concept of metabolic disruption through exposure to chemicals has expanded our understanding of how environmental pollution can contribute to metabolic dysregulation and, ultimately, diseases like obesity. New strategies for assessing …
View article: Circulating Immune Cell Signature Analysis in HFpEF Across Species
Circulating Immune Cell Signature Analysis in HFpEF Across Species Open
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical picture that is closely related to extracardiac comorbidities such as obesity, hypertension, and diabetes and is associated with chronic, low-gr…
View article: HOOK1 Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits
HOOK1 Gene Expression and DNA Methylation in Obesity and Related Cardiometabolic Traits Open
Introduction: Accumulation of fat in omental visceral adipose tissue (OVAT) is strongly linked to metabolic diseases. Our recent findings show a distinct and more accessible chromatin landscape of the visceral depot compared to its subcuta…
View article: Recognising, quantifying and accounting for classification uncertainty in type 2 diabetes subtypes
Recognising, quantifying and accounting for classification uncertainty in type 2 diabetes subtypes Open
Aims/hypothesis Despite continued interest in precision diagnostics and type 2 diabetes subtypes, the challenge of uncertainty in the classification of individuals into subtypes remains. This study introduces a novel method for quantifying…
View article: Closing the Gap in Behavioral Weight Loss Therapy: Prospective Analysis of Clinical Real-World Data of a Four-Year Health Insurance-Financed Program
Closing the Gap in Behavioral Weight Loss Therapy: Prospective Analysis of Clinical Real-World Data of a Four-Year Health Insurance-Financed Program Open
Our four-year interdisciplinary behavioral weight loss program is fully covered by public health insurance for patients with a body mass index of ≥35 kg/m2. We evaluated the real-world outcomes of anthropometric, metabolic and psychologic …
View article: Author Correction: Adipose tissue retains an epigenetic memory of obesity after weight loss
Author Correction: Adipose tissue retains an epigenetic memory of obesity after weight loss Open
View article: Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure
Human adipose tissue gene expression signatures indicate an inflammatory response and retinoic receptor activation under persistent organic pollutants exposure Open
Adipose tissue (AT) is subject to permanent accumulation of persistent organic pollutants (POP) due to their hydrophobic nature. Therefore, AT can be considered as interface between the body and an increasingly complex exposure to the chem…
View article: Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals
Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals Open
Background/objectives Obesity poses a major public health concern. Although BMI heritability is estimated at 40–80%, genetic diagnostics remain challenging. This study aims to (i) assess the diagnostic yield of monogenic obesity in a large…
View article: The effect of 6 months of structured strength or endurance exercise program on weight loss after gastric bypass surgery in a randomized controlled trial
The effect of 6 months of structured strength or endurance exercise program on weight loss after gastric bypass surgery in a randomized controlled trial Open