Matthias Brückner
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View article: MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia
MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia Open
MotiQ is an open-source software for automated quantification of microglial motility and morphology. MotiQ can be applied to in vivo, ex vivo, and in vitro data from confocal, epifluorescence, and two-photon microscopy. MotiQ is not limite…
View article: Generation of specialized blood vessels via lymphatic transdifferentiation
Generation of specialized blood vessels via lymphatic transdifferentiation Open
View article: Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology Open
View article: Generation of specialized blood vessels through transdifferentiation of lymphatic endothelial cells
Generation of specialized blood vessels through transdifferentiation of lymphatic endothelial cells Open
The lineage and developmental trajectory of a cell are key determinants of cellular identity. Yet, the functional relevance of deriving a specific cell type from ontologically distinct progenitors, remains an open question. In the case of …
View article: New role of P2X7 receptor in an Alzheimer’s disease mouse model
New role of P2X7 receptor in an Alzheimer’s disease mouse model Open
Extracellular aggregates of amyloid β (Aβ) peptides, which are characteristic of Alzheimer's disease (AD), act as an essential trigger for glial cell activation and the release of ATP, leading to the stimulation of purinergic receptors, es…
View article: Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint
Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint Open
We consider estimation of treatment effects in two-stage adaptive multi-arm trials with a common control. The best treatment is selected at interim, and the primary endpoint is modeled via a Cox proportional hazards model. The maximum part…
View article: Comparison of different contouring definitions of the rectum as organ at risk (OAR) and dose–volume parameters predicting rectal inflammation in radiotherapy of prostate cancer: which definition to use?
Comparison of different contouring definitions of the rectum as organ at risk (OAR) and dose–volume parameters predicting rectal inflammation in radiotherapy of prostate cancer: which definition to use? Open
Objective: The objective of this retrospective planning study was to find a contouring definition for the rectum as an organ at risk (OAR) in curative three-dimensional external beam radiotherapy (EBRT) for prostate cancer (PCa) with a pre…
View article: βB2-Crystallin Promotes Axonal Regeneration in the Injured Optic Nerve in Adult Rats
βB2-Crystallin Promotes Axonal Regeneration in the Injured Optic Nerve in Adult Rats Open
The purpose of the study was to further scrutinize the potential of βB2-crystallin in supporting regeneration of injured retinal ganglion cell axons both in vitro and in vivo. Retinal explants obtained from animals after treatment either w…