Matthias Buechter
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View article: Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid
Obeticholic Acid Improves Cholestasis, Liver Fibrosis, and Liver Function in Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid Open
Background and Aims: Primary biliary cholangitis (PBC) leads to the slow, progressive destruction of the small bile ducts with consecutive cholestasis and intrahepatic cholangitis. If this disease remains untreated, liver parenchyma will b…
View article: Factors Positively Correlated with Hepatitis B Surface Antigen Seroconversion in Chronic Hepatitis B
Factors Positively Correlated with Hepatitis B Surface Antigen Seroconversion in Chronic Hepatitis B Open
Background and Aims: Chronic hepatitis B virus (HBV) infection is a global public health challenge since more than 250 million individuals are affected worldwide. Since different treatment modalities are available and not all patients are …
View article: Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis—The 20-Year Experience of a High-Volume Tertiary Center
Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis—The 20-Year Experience of a High-Volume Tertiary Center Open
Background and aims: Autoimmune hepatitis (AIH) is a complex and progressive inflammatory liver disease characterized by immune-mediated destruction of the liver parenchyma, hypergammaglobulinemia, the presence of circulating autoantibodie…
View article: No Differences in Rotational Thromboelastometry Measurements between Portal and Peripheral Circulation in Cirrhotic Patients Undergoing TIPS
No Differences in Rotational Thromboelastometry Measurements between Portal and Peripheral Circulation in Cirrhotic Patients Undergoing TIPS Open
Background: In patients with liver cirrhosis, transjugular intrahepatic portosystemic shunt (TIPS) is considered a standardized treatment of refractory ascites or variceal bleeding. TIPS thrombosis (TT) and/or portal vein thrombosis (PVT) …
View article: Liver Function—How to Screen and to Diagnose: Insights from Personal Experiences, Controlled Clinical Studies and Future Perspectives
Liver Function—How to Screen and to Diagnose: Insights from Personal Experiences, Controlled Clinical Studies and Future Perspectives Open
Acute and chronic liver disease is a relevant problem worldwide. Liver function plays a crucial role in the course of liver diseases not only in estimating prognosis but also with regard to therapeutic interventions. Within this review, we…
View article: High volume retrograde portography for better discrimination of the portal vein during TIPS procedure
High volume retrograde portography for better discrimination of the portal vein during TIPS procedure Open
Background: Imaging of the portal vein prior to puncture for TIPS is essential. Purpose: With this study, we examined a modified retrograde portography with regard to the reliable representation of the portal vein. Material and Methods: Pr…
View article: FIB-4 and APRI as Predictive Factors for Short- and Long-Term Survival in Patients with Transjugular Intrahepatic Portosystemic Stent Shunts
FIB-4 and APRI as Predictive Factors for Short- and Long-Term Survival in Patients with Transjugular Intrahepatic Portosystemic Stent Shunts Open
(1) Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a standard therapy for portal hypertension. We aimed to explore the association of established baseline scores with TIPS outcomes. (2) Methods: In total, 136 liver cir…
View article: Supplementary Material for: Performance of the LiMAx test, fibrinogen, and transient elastography in patients with acute liver injury
Supplementary Material for: Performance of the LiMAx test, fibrinogen, and transient elastography in patients with acute liver injury Open
Background Acute liver failure (ALF) occurs as a rare, sudden, extensive loss of liver function in a previously healthy liver. In advanced cases, ALF may require liver transplantation (LT). Available prognostic parameters have limited accu…
View article: Enzymatic liver function measured by LiMAx is superior to current standard methods in predicting transplant-free survival after TIPS implantation
Enzymatic liver function measured by LiMAx is superior to current standard methods in predicting transplant-free survival after TIPS implantation Open
Transjugular intrahepatic portosystemic shunt (TIPS) is one of the main treatment options in patients with decompensated liver cirrhosis but is still associated with partly severe complications. For adequate patient selection, prognostic p…
View article: Characteristics and Long-term Outcome of 535 Patients with Histologically Confirmed Autoimmune Hepatitis (AIH) - A Single Center Experience of 18 Years
Characteristics and Long-term Outcome of 535 Patients with Histologically Confirmed Autoimmune Hepatitis (AIH) - A Single Center Experience of 18 Years Open
Introduction: Autoimmune hepatitis (AIH) is a rare liver disease with a favorable prognosis following immunosuppression. In this work-up, we present our long-term experience with this patient collective. Patients and Methods: Overall, we w…
View article: Non-invasive detection of liver cirrhosis - the “Essen algorithm”
Non-invasive detection of liver cirrhosis - the “Essen algorithm” Open
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and th…
View article: Evaluation of liver function before and during therapy
Evaluation of liver function before and during therapy Open
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and th…
View article: FIB-4 and APRI-scores predict survival in patients with transjugular intrahepatic portosystemic stent shunts
FIB-4 and APRI-scores predict survival in patients with transjugular intrahepatic portosystemic stent shunts Open
Measuring the density of iodine depositions: Detecting an invisible residual tumor after conventional transarterial chemoembolization Open
View article: Predictive value of spleen stiffness in hepatocellular carcinoma
Predictive value of spleen stiffness in hepatocellular carcinoma Open
In their Letter to the Editor, Wei et al . address on the role of spleen stiffness measurement (SSM) for predicting the late recurrence (>24 months post-surgery) of hepatocellular carcinoma (HCC) after resection (1). They comment on a rec…
View article: Enzymatic liver function measured by LiMAx – a reliable diagnostic and prognostic tool in chronic liver disease
Enzymatic liver function measured by LiMAx – a reliable diagnostic and prognostic tool in chronic liver disease Open
Chronic liver disease (CLD) is a major cause of morbidity and mortality worldwide. Non-invasive assessment of hepatic disease severity represents a relevant issue to further improve clinical management and therapeutic treatment. We retrosp…
View article: Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis
Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis Open
BACKGROUND Germany has the highest rate of patients dying or becoming unfit for transplant while waitlisted within the Eurotransplant region. Therefore, the aim of the current study was to analyze mortality as well as risk factors for mort…
View article: Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report
Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report Open
View article: Comparison of the sixth and the seventh editions of the UICC classification for intrahepatic cholangiocarcinoma
Comparison of the sixth and the seventh editions of the UICC classification for intrahepatic cholangiocarcinoma Open
View article: Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients
Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients Open
Drugs, viral infections, and previous surgery may trigger ALF as the initial presentation of AIH. Advanced age and high MELD-score were associated with lethal outcome.
View article: Course of hepatitis E infection in a patient with rheumatoid arthritis and autoimmune hepatitis
Course of hepatitis E infection in a patient with rheumatoid arthritis and autoimmune hepatitis Open
Despite the HEV infection and due to the strength of autoimmunity, we decided to continue immunosuppressive therapy and monitored HEV-PCR regularly. However, HEV-RNA became negative after 2 months and HEV-IgM turned negative after 13 month…
View article: Partial spleen embolization reduces the risk of portal hypertension-induced upper gastrointestinal bleeding in patients not eligible for TIPS implantation
Partial spleen embolization reduces the risk of portal hypertension-induced upper gastrointestinal bleeding in patients not eligible for TIPS implantation Open
Partial SE, as a minimally invasive intervention with low procedure-associated complications, may be a valuable alternative for patients with recurrent PH-induced UGIB refractory to standard therapy.
View article: De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report
De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report Open
: A 49-year-old male patient was referred to our institution for acute liver failure (ALV). Apart from cholestasis, coagulopathy, and hepatic encephalopathy (HE) I°, laboratory studies revealed a significant increase in liver enzymes with …
View article: Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience Open
Introduction . Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods . We analyzed 36 pat…
View article: Acute occlusion of the ductus pancreaticus due to abdominal aortic aneurysm: Uncommon cause of silent severe acute pancreatitis - a case report and review of the literature
Acute occlusion of the ductus pancreaticus due to abdominal aortic aneurysm: Uncommon cause of silent severe acute pancreatitis - a case report and review of the literature Open
We report an uncommon case of severe silent acute pancreatitis (SSAP) caused by compression of the Ductuspancreaticus due to an abdominal aortic aneurysm (AAA) of 79 mm × 59 mm external diameter. A 78-year-old patient with knowncutaneous p…