Matthias Canault
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View article: High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis
High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis Open
Linking the genetic background of patients with bleeding diathesis and altered platelet function remains challenging. We aimed to assess how a multiparameter microspot-based measurement of thrombus formation under flow can help identify pa…
View article: Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice
Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice Open
Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due to its deleterious dose-related side effects. We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardio…
View article: Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis
Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis Open
Peritonitis and subsequent sepsis lead to high morbidity and mortality in response to uncontrolled systemic inflammation primarily mediated by macrophages. Nicotinamide adenine dinucleotide (NAD+) is an important regulator of oxidative str…
View article: GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis
GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis Open
View article: Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats
Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats Open
β-nicotinamide mononucleotide (NMN) is a natural molecule intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Preclinical evidences point to the beneficial effect of NMN administration on several age-re…
View article: TicagRelor Or Clopidogrel in severe or terminal chronic kidney patients Undergoing PERcutaneous coronary intervention for acute coronary syndrome: The TROUPER trial
TicagRelor Or Clopidogrel in severe or terminal chronic kidney patients Undergoing PERcutaneous coronary intervention for acute coronary syndrome: The TROUPER trial Open
View article: RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology
RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology Open
RasGRP2 is calcium and diacylglycerol-regulated guanine nucleotide exchange factor I that activates Rap1, which is an essential signaling-knot in “inside-out” αIIbβ3 integrin activation in platelets. Inherited platelet function disorder ca…
View article: Subcellular localization of Rap1 GTPase activator CalDAG‐GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides
Subcellular localization of Rap1 GTPase activator CalDAG‐GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides Open
View article: ISSUE INFORMATION
ISSUE INFORMATION Open
View article: Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment in acute coronary syndrome
Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment in acute coronary syndrome Open
Antiplatelet therapy through inhibition of the adenosine diphosphate (ADP)/P2Y12 pathway is commonly used in the treatment of acute coronary syndrome (ACS). Although efficient in preventing platelet activation and thrombus formation, it in…
View article: Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human
Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human Open
SUMMARY Syndromes caused by mutations in Ras-MAP kinase signaling molecules are known as RASopathies and share features such as developmental delay, autistic traits, and cancer. Syndromic features of Rap-MAP kinase signaling defects remain…
View article: A Novel Rapid Method of Red Blood Cell and Platelet Permeabilization and Staining for Flow Cytometry Analysis
A Novel Rapid Method of Red Blood Cell and Platelet Permeabilization and Staining for Flow Cytometry Analysis Open
BACKGROUND Flow cytometry essentially focuses on surface‐expressed proteins, with few protocols being devoted to intracellular components. We evaluated a two‐step procedure using new formaldehyde‐free permeabilization and staining reagents…
View article: Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis
Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis Open
Increased platelet activity occurs in type 2 diabetes mellitus (T2DM) and such platelet dysregulation likely originates from altered megakaryopoiesis. We initiated identification of dysregulated pathways in megakaryocytes in the setting of…
View article: ISSUE INFORMATION
ISSUE INFORMATION Open
Research and Prac ce in Thrombosis andHaemostasis (RPTH) is the newest journal of the Interna onal Society on Thrombosis and Haemostasis (ISTH) and the newest journal in the fi eld of thrombosis and hemostasis.Complemen ng
View article: Letter by Laine et al Regarding Article, “Antithrombotic Agents: New Directions in Antithrombotic Therapy”
Letter by Laine et al Regarding Article, “Antithrombotic Agents: New Directions in Antithrombotic Therapy” Open
View article: Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation
Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation Open
International audience
View article: Peripartum bleeding management in a patient with Cal<scp>DAG</scp>‐<scp>GEFI</scp> deficiency
Peripartum bleeding management in a patient with Cal<span>DAG</span>‐<span>GEFI</span> deficiency Open
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View article: Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding
Expanded repertoire of RASGRP2 variants responsible for platelet dysfunction and severe bleeding Open
Key Points Eleven pedigrees were identified with biallelic pathogenic variants in RASGPR2, which encodes platelet CalDAG-GEFI. CalDAG-GEFI deficiency is a severe, recessive, nonsyndromic platelet function disorder with defective aggregatio…
View article: Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features
Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features Open
Congenital macrothrombocytopenia is a family of rare diseases, of which a significant fraction remains to be genetically characterized. To analyze cases of unexplained thrombocytopenia, 27 individuals from a patient cohort of the Bleeding …
View article: Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.
Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors. Open
Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy. We sequenced the DNA from cases w…
View article: Germline variants in <i>ETV6</i> underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34 <sup>+</sup> progenitors
Germline variants in <i>ETV6</i> underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34 <sup>+</sup> progenitors Open
Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy. We sequenced the DNA from cases w…
View article: Role of eNOS‐ and NOX‐containing microparticles in endothelial dysfunction in patients with obesity
Role of eNOS‐ and NOX‐containing microparticles in endothelial dysfunction in patients with obesity Open
Objective To explore the pathophysiological profile of patients who have obesity and to investigate the potential role of circulating microparticles (MPs) in endothelial dysfunction in patients who have obesity. Methods The inflammatory an…
View article: Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the<i>ITGA2B</i>and<i>ITGB3</i>Genes in a Large International Cohort
Expanding the Mutation Spectrum Affecting αIIbβ3 Integrin in Glanzmann Thrombasthenia: Screening of the<i>ITGA2B</i>and<i>ITGB3</i>Genes in a Large International Cohort Open
International audience