Matthias Goebeler
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View article: Brentuximab‐Vedotin als Mono‐ oder Kombinationstherapie bei kutanen peripheren T‐Zell‐Lymphomen – eine retrospektive Analyse
Brentuximab‐Vedotin als Mono‐ oder Kombinationstherapie bei kutanen peripheren T‐Zell‐Lymphomen – eine retrospektive Analyse Open
Zusammenfassung Hintergrund Kutane periphere T‐Zell‐Lymphome (PTCL) sind selten und zeigen einen aggressiven Verlauf mit limitiertem Therapieansprechen. Die Wirksamkeit von Brentuximab‐Vedotin bei kutanen PTCL wurde bisher nicht systematis…
View article: Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy
Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy Open
Background Metal allergies are prime examples of delayed‐type hypersensitivity divided into two phases: in the sensitization phase, initial contact with an allergen leads to activation of skin‐resident cells and formation of metal‐reactive…
View article: MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression
MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression Open
Despite the advent of immune-oncological therapies, patients with advanced NRAS -mutant melanoma still have a significantly worse prognosis than their BRAF -mutant counterparts. This is mainly due to a high propensity for resistance to ava…
View article: Brentuximab vedotin and radiotherapy for CD30‐positive cutaneous T‐cell lymphoma – a retrospective multicenter analysis
Brentuximab vedotin and radiotherapy for CD30‐positive cutaneous T‐cell lymphoma – a retrospective multicenter analysis Open
Summary Background and Objectives While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30‐positive cutaneous T‐cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy a…
View article: High Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Hidradenitis Suppurativa: A Guide to Easily Assess the Clinical Risk of Comorbid Liver Disease
High Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Hidradenitis Suppurativa: A Guide to Easily Assess the Clinical Risk of Comorbid Liver Disease Open
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with considerable comorbidity. The link between HS and metabolic dysfunction-associated steatotic liver disease (MASLD) is of particular interest owing to sh…
View article: NFATc1 Abrogation in B Cells Ameliorates Contact Hypersensitivity Responses
NFATc1 Abrogation in B Cells Ameliorates Contact Hypersensitivity Responses Open
Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease that evolves upon exposure to contact allergens in sensitized individuals. Both the adaptive and innate immune system play pivotal roles in the pathogenesis of ACD. …
View article: Brentuximab vedotin as monotherapy or combination therapy for cutaneous peripheral T cell lymphoma – a retrospective study
Brentuximab vedotin as monotherapy or combination therapy for cutaneous peripheral T cell lymphoma – a retrospective study Open
Summary Background Cutaneous peripheral T cell lymphomas (PTCL) are rare and show an aggressive course with limited response to therapy. The efficacy of brentuximab vedotin in cutaneous peripheral T cell lymphomas has not yet been systemat…
View article: Influence of a Th17-Inducing Cytokine Milieu on Phenotypical and Functional Properties of Regulatory T Cells in Chronic Inflammatory Arthritis
Influence of a Th17-Inducing Cytokine Milieu on Phenotypical and Functional Properties of Regulatory T Cells in Chronic Inflammatory Arthritis Open
Considering the high plasticity of FoxP3+ regulatory T (Treg) cells and Interleukin (IL)-17-producing Th17 cells, we hypothesized that a Th17 inflammatory milieu may impair the functional properties of Treg cells in chronic inflammatory ar…
View article: Identifying and Evaluating Mobile and Web Apps for Patients to Manage Hidradenitis Suppurativa: Systematic Search in App Stores and Content Analysis
Identifying and Evaluating Mobile and Web Apps for Patients to Manage Hidradenitis Suppurativa: Systematic Search in App Stores and Content Analysis Open
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas in intertriginous sites. It significantly impacts patients’ quality of life. Early diagnosis and time…
View article: Vaccination in dermatology 2025: Update considering current recommendations of the German Standing Committee on Vaccination
Vaccination in dermatology 2025: Update considering current recommendations of the German Standing Committee on Vaccination Open
Summary The immunosuppressive and immunomodulatory treatment of dermatological patients necessitates the regular review and updating of standard vaccinations and vaccines indicated for specific conditions. The German Standing Committee on …
View article: Case Report: Effectiveness of deucravacitinib in chronic recurrent multifocal osteomyelitis and concomitant psoriasis
Case Report: Effectiveness of deucravacitinib in chronic recurrent multifocal osteomyelitis and concomitant psoriasis Open
We present the case of a 22-year-old male who was first diagnosed with chronic recurrent multifocal osteomyelitis (CRMO) at the age of 16 years. During treatment with the tumor necrosis factor (TNF)-alpha inhibitor adalimumab, he developed…
View article: Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study Open
Artificial intelligence (AI) systems substantially improve dermatologists’ diagnostic accuracy for melanoma, with explainable AI (XAI) systems further enhancing their confidence and trust in AI-driven decisions. Despite these advancements,…
View article: Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion
Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion Open
In the bullous autoimmune disease pemphigus vulgaris (PV), autoantibodies directed mainly against desmoglein 1 (Dsg1) and Dsg3 cause loss of desmosomal adhesion. We recently showed that intracellular cAMP increase by the phosphodiesterase …
View article: Patient-Centered Lupus Erythematosus Mobile Apps: Systematic Search and Evaluation by Patients and Physicians (Preprint)
Patient-Centered Lupus Erythematosus Mobile Apps: Systematic Search and Evaluation by Patients and Physicians (Preprint) Open
BACKGROUND Lupus erythematosus (LE) is a chronic autoimmune disease that significantly impacts patients' quality of life. Photosensitivity is a key impairment that severely limits the quality of life, especially in cutaneous lupus erythem…
View article: History, clinical presentation, therapy, and patient reported outcomes of mucosal lichen planus: a cross‐sectional study
History, clinical presentation, therapy, and patient reported outcomes of mucosal lichen planus: a cross‐sectional study Open
Summary Background and Objectives Mucosal lichen planus (LP) is a chronic inflammatory disease. The patient's journey can be arduous as diagnosis and therapy are challenging. Patients and Methods In this cross‐sectional study, a wide range…
View article: Patient-Centered Urticaria Mobile Apps: Systematic Identification, Analysis and Assessment (Preprint)
Patient-Centered Urticaria Mobile Apps: Systematic Identification, Analysis and Assessment (Preprint) Open
BACKGROUND Urticaria is a prevalent disease characterized by the appearance of wheals and/or angioedema. The transient, frequently intermittent wheals cause severe pruritus and have a significant impact on the lives of those affected. Eff…
View article: Effectiveness of Tildrakizumab in the Long‐Term Treatment of Plaque Psoriasis: A Retrospective, Multicenter Analysis Over 76 Weeks
Effectiveness of Tildrakizumab in the Long‐Term Treatment of Plaque Psoriasis: A Retrospective, Multicenter Analysis Over 76 Weeks Open
Background: Psoriasis is a chronic inflammatory disease affecting skin and patients’ quality of life. Tildrakizumab is an IL‐23p19‐inhibitor approved for treatment of moderate‐to‐severe plaque psoriasis. Objective: To evaluate the effectiv…
View article: NFATc1 Fosters Allergic Contact Dermatitis Responses by Enhancing the Induction of IL-17–Producing CD8 Cells
NFATc1 Fosters Allergic Contact Dermatitis Responses by Enhancing the Induction of IL-17–Producing CD8 Cells Open
A plethora of data supports a major role of CD4+ and CD8+ T lymphocytes for the initiation, progression, and maintenance of allergic contact dermatitis. However, in-depth understanding of the molecular mechanisms is still limited. NFATc1 p…
View article: Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice
Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice Open
Digital papillary adenocarcinoma (DPAC) is a rare, low-grade sweat gland carcinoma primarily found on the hands, fingers, or toes and predominantly affecting males. Distinguishing DPAC from benign sweat gland tumors can be challenging. We …
View article: Re-exposition to ipilimumab plus nivolumab in metastatic Merkel cell carcinoma
Re-exposition to ipilimumab plus nivolumab in metastatic Merkel cell carcinoma Open
Background Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous malignancy. Immune checkpoint inhibition (ICI) with PD-(L)1 blockade has significantly improved treatment outcomes in metastatic disease. In patients with pri…
View article: Patient-Centered Hidradenitis suppurativa Mobile Apps: Systematic Identification, Analysis and Assessment (Preprint)
Patient-Centered Hidradenitis suppurativa Mobile Apps: Systematic Identification, Analysis and Assessment (Preprint) Open
BACKGROUND Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by inflammatory nodules, abscesses and fistulas in intertriginous sites such as the axilla, groin and anogenital areas. HS lesions cause persist…
View article: Bee/Vespula Venom-Specific IgE Ratio Greater Than 5:1 Indicates Culprit Insect in Double-Sensitized Patients
Bee/Vespula Venom-Specific IgE Ratio Greater Than 5:1 Indicates Culprit Insect in Double-Sensitized Patients Open
Dominant specific IgE at a ratio of 5:1 indicates the culprit venom in double-sensitized allergic patients. Additional component-resolved diagnostic testing can be restricted to cases with double sensitization to whole venom at a ratio of …
View article: Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study Open
Artificial intelligence (AI) systems have substantially improved dermatologists' diagnostic accuracy for melanoma, with explainable AI (XAI) systems further enhancing clinicians' confidence and trust in AI-driven decisions. Despite these a…
View article: Prospective multicenter study using artificial intelligence to improve dermoscopic melanoma diagnosis in patient care
Prospective multicenter study using artificial intelligence to improve dermoscopic melanoma diagnosis in patient care Open
Background Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective studies, artificial intelligence (AI) has proven to be helpful for enhancing mela…
View article: Anti-p200 Pemphigoid Mimicking Acquired Reactive Perforating Collagenosis
Anti-p200 Pemphigoid Mimicking Acquired Reactive Perforating Collagenosis Open
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