Matthias Günther
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View article: Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: Machine learning results from the German National Cohort (NAKO) study
Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: Machine learning results from the German National Cohort (NAKO) study Open
Anxiety disorders (ANX) are common and impairing mental health conditions. This study aimed to classify self-reported symptoms of generalized anxiety disorder (GAD) and panic attacks as two psychopathological manifestations of ANX by apply…
View article: On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models
On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models Open
Purpose Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it …
View article: Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: Machine learning results from the German National Cohort (NAKO) study
Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: Machine learning results from the German National Cohort (NAKO) study Open
Anxiety disorders (ANX) are common and impairing mental health conditions. This study aimed to classify self-reported symptoms of generalized anxiety disorder (GAD) and panic attacks as two psychopathological manifestations of ANX by apply…
View article: Brain Perfusion Imaging of a Large Population: Arterial Spin Labelling MRI in UK Biobank
Brain Perfusion Imaging of a Large Population: Arterial Spin Labelling MRI in UK Biobank Open
Blood flow to the brain is a sensitive marker of neuronal activity as well as of a number of diseases, including stroke, tumours and neurodegenerative conditions. Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (…
View article: Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO)
Associations of road traffic noise with adipose tissue depots and hepatic fat content – Results from the German National Cohort (NAKO) Open
View article: Noninvasive blood–brain barrier integrity mapping in patients with high‐grade glioma and metastasis by multi–echo time–encoded arterial spin labeling
Noninvasive blood–brain barrier integrity mapping in patients with high‐grade glioma and metastasis by multi–echo time–encoded arterial spin labeling Open
Purpose In brain tumors, disruption of the blood–brain barrier (BBB) indicates malignancy. Clinical assessment is qualitative; quantitative evaluation is feasible using the K 2 leakage parameter from dynamic susceptibility contrast MRI. Ho…
View article: Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study
Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study Open
An emerging biomarker of blood-brain barrier (BBB) permeability is the time of exchange (Tex) of water from the blood to tissue, as measured by multi-echo arterial spin labeling (ASL) MRI. This new non-invasive sequence, already tested in …
View article: Blood-Brain Barrier Water Exchange in Relation to Amyloid, Cognition and Cerebrovascular Burden
Blood-Brain Barrier Water Exchange in Relation to Amyloid, Cognition and Cerebrovascular Burden Open
View article: Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial
Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial Open
This study provides Class II evidence that for patients with unknown-onset ischemic stroke with AVO, MRI-guided treatment with IV tissue plasminogen activator improves outcomes.
View article: Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence
Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence Open
Water exchange rate (Kw) across the blood–brain barrier (BBB) is an important physiological parameter that may provide new insight into ageing and neurodegenerative disease. Recently, two non‐invasive arterial spin labelling (ASL) MRI meth…
View article: Baseline MRI examination in the NAKO Health Study—findings on feasibility, participation and dropout rates, comfort, and image quality
Baseline MRI examination in the NAKO Health Study—findings on feasibility, participation and dropout rates, comfort, and image quality Open
Whole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on a…
View article: Recommendations for quantitative cerebral perfusion <scp>MRI</scp> using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications
Recommendations for quantitative cerebral perfusion <span>MRI</span> using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications Open
Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview of qu…
View article: Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol
Developing blood-brain barrier arterial spin labelling as a non-invasive early biomarker of Alzheimer’s disease (DEBBIE-AD): a prospective observational multicohort study protocol Open
Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the earliest microvascular signs of Alzheimer’s disease (AD). Existing BBB integrity imaging methods involve contrast agents or ionising radiation, and p…
View article: Model‐based analysis and specification of functional requirements and tests for complex automotive systems
Model‐based analysis and specification of functional requirements and tests for complex automotive systems Open
The specification of requirements and tests are crucial activities in automotive development projects. However, due to the increasing complexity of automotive systems, practitioners fail to specify requirements and tests for distributed an…
View article: Insights into single-timepoint ASL hemodynamics: what visual assessment and spatial coefficient of variation can tell
Insights into single-timepoint ASL hemodynamics: what visual assessment and spatial coefficient of variation can tell Open
Purpose Arterial spin labeling (ASL) represents a noninvasive perfusion biomarker, and, in the study of nonvascular disease, the use of the single-timepoint ASL technique is recommended. However, the obtained cerebral blood flow (CBF) maps…
View article: Normal Blood-Brain Barrier Water Permeability Across the Lifespan: A Multi-Echo Asl Study
Normal Blood-Brain Barrier Water Permeability Across the Lifespan: A Multi-Echo Asl Study Open
View article: DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design
DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design Open
Introduction: Arterial spin labeling (ASL) MRI, a non-invasive technique for imaging perfusion, now allows studying BBB permeability. The DEveloping BBB-ASL as a non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD) multi-cohort …
View article: Blood‐brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan
Blood‐brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan Open
Background Blood‐brain barrier (BBB) dysfunction is considered a hallmark of Alzheimer’s disease (AD), making non‐invasive imaging of BBB with arterial spin labeling (ASL) MRI a potential imaging biomarker (BBB‐ASL). However, the normal BB…
View article: Blood‐brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan
Blood‐brain barrier permeability measured with arterial spin labeling as potential cerebrovascular biomarker over the lifespan Open
Background Blood‐brain barrier (BBB) dysfunction is considered a hallmark of Alzheimer’s disease (AD), making non‐invasive imaging of BBB with arterial spin labeling (ASL) MRI a potential imaging biomarker (BBB‐ASL). However, the normal BB…
View article: Associations Between Cardiovascular Risk Factors and Arterial Spin Labelling Derived Perfusion Parameters
Associations Between Cardiovascular Risk Factors and Arterial Spin Labelling Derived Perfusion Parameters Open
Background Decreased cerebral blood flow (CBF) and deterioration of blood‐brain barrier (BBB) are suggested to be precursor conditions of cognitive impairment. Using a novel multi‐echo‐time arterial spin labelling (ASL) protocol, we examin…
View article: Subject-specific timing adaption in time-encoded arterial spin labeling imaging
Subject-specific timing adaption in time-encoded arterial spin labeling imaging Open
Objectives One challenge in arterial spin labeling (ASL) is the high variability of arterial transit times (ATT), which causes associated arterial transit delay (ATD) artifacts. In patients with pathological changes, these artifacts occur …
View article: Recommendations for Quantitative Cerebral Perfusion MRI using Multi-Timepoint Arterial Spin Labeling: Acquisition, Quantification, and Clinical Applications
Recommendations for Quantitative Cerebral Perfusion MRI using Multi-Timepoint Arterial Spin Labeling: Acquisition, Quantification, and Clinical Applications Open
Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of qu…
View article: Blood–Brain Barrier Permeability to Water Measured Using Multiple Echo Time Arterial Spin Labeling <scp>MRI</scp> in the Aging Human Brain
Blood–Brain Barrier Permeability to Water Measured Using Multiple Echo Time Arterial Spin Labeling <span>MRI</span> in the Aging Human Brain Open
Background The blood–brain barrier (BBB) plays a vital role in maintaining brain homeostasis, but the integrity of this barrier deteriorates slowly with aging. Noninvasive water exchange magnetic resonance imaging (MRI) methods may identif…
View article: AI-driven and automated MRI sequence optimization in scanner-independent MRI sequences formulated by a domain-specific language
AI-driven and automated MRI sequence optimization in scanner-independent MRI sequences formulated by a domain-specific language Open
Introduction The complexity of Magnetic Resonance Imaging (MRI) sequences requires expert knowledge about the underlying contrast mechanisms to select from the wide range of available applications and protocols. Automation of this process …
View article: MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange Open
View article: Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective
Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective Open
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in- and outflow of molecules from the blood to brain parenchyma, protecting the brain’s microenvironment. If one of the BBB components starts to fail, it…
View article: Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells Open
View article: Current state and guidance on arterial spin labeling perfusion <scp>MRI</scp> in clinical neuroimaging
Current state and guidance on arterial spin labeling perfusion <span>MRI</span> in clinical neuroimaging Open
This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recomme…
View article: Framework and baseline examination of the German National Cohort (NAKO)
Framework and baseline examination of the German National Cohort (NAKO) Open
View article: Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study Open
Introduction Magnetic resonance imaging (MRI) of the brain could be a key diagnostic and research tool for understanding the neuropsychiatric complications of COVID-19. For maximum impact, multi-modal MRI protocols will be needed to measur…