Matthias Hackl
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View article: Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury
Serum MicroRNA signatures associated with hypertrophic callus formation in polytrauma patients with traumatic brain injury Open
Long-bone fractures occasionally develop excessive callus formation in the presence of traumatic brain injury, a clinically relevant but poorly understood injury response. Although this phenomenon is known for decades, the causal factors a…
View article: Synovial Fluid MicroRNA Biomarkers Enable Accurate Diagnosis of Hip and Knee Periprosthetic Joint Infections
Synovial Fluid MicroRNA Biomarkers Enable Accurate Diagnosis of Hip and Knee Periprosthetic Joint Infections Open
Background: Diagnosing hip and knee periprosthetic joint infections (PJIs) is challenging, necessitating sensitive and specific biomarkers for accurate diagnosis. Cell-free microRNAs (miRNAs) are emerging as noninvasive biomarkers. We hypo…
View article: Distinct miRNA profiles in human amniotic tissue and its vesicular and non-vesicular secretome
Distinct miRNA profiles in human amniotic tissue and its vesicular and non-vesicular secretome Open
Introduction The human amniotic membrane (hAM) has largely been used in tissue regeneration and wound healing applications. A promising alternative to decellularized hAM or isolated cells is the usage of native viable hAM which contains an…
View article: MON-790 The Use Of Microrna Ratios To Predict Fractures In Older Women: The Opus Study
MON-790 The Use Of Microrna Ratios To Predict Fractures In Older Women: The Opus Study Open
Disclosure: D. Carro Vazquez: None. P. Zarecki: None. A. Duseja: None. M. Hackl: Matthias Hackl is CEO and founder of TAmiRNA GmbH. K.C. Glüer: None. D.M. Reid: None. C. Roux: None. G. Armbrecht: None. F. Gossiel: None. M. Paggiosi: None. …
View article: Validation of plasma microRNAs as biomarkers in sepsis associated acute kidney injury upon first clinical presentation reveals limited diagnostic and prognostic performance
Validation of plasma microRNAs as biomarkers in sepsis associated acute kidney injury upon first clinical presentation reveals limited diagnostic and prognostic performance Open
Background Sepsis is a life-threatening response to an infection, often complicated by sepsis-associated acute kidney injury (SA-AKI). Early recognition of SA-AKI is critical but challenged by the limited sensitivity of existing diagnostic…
View article: Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis
Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis Open
Background Osteoarthritis (OA) remains an intractable condition due to the limited regenerative capacity of adult cartilage. Extracellular vesicles (EVs) have emerged as promising therapeutics, yet the optimal donor cell source is still un…
View article: TechNote - Minimum Preanalytical Information for the Publication of Studies on Circulating Cell-Free microRNA-based Biomarkers
TechNote - Minimum Preanalytical Information for the Publication of Studies on Circulating Cell-Free microRNA-based Biomarkers Open
Circulating cell-free microRNAs (miRNAs) are emerging as promising biomarkers with broad potential for clinical applications. However, pre-analytical variability significantly affects miRNA quantification and hampers reproducibility across…
View article: Identification of a hydroxycinnamoyl‐<scp>CoA</scp> double bond reductase (<scp>HDR</scp>) affirms multiple pathways for dihydrochalcone formation in apple
Identification of a hydroxycinnamoyl‐<span>CoA</span> double bond reductase (<span>HDR</span>) affirms multiple pathways for dihydrochalcone formation in apple Open
Summary Dihydrochalcones are secondary metabolites with manifold dietary and pharmaceutical properties, but with a yet unclear function in plants. The abundance of dihydrochalcones, particularly phloridzin, makes Malus ssp. unique in the p…
View article: Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics
Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics Open
The unsuccessful translation of cardiac regeneration and cardioprotection from animal experiments to clinical applications in humans has raised the question of whether microRNA bioinformatics can narrow the gap between animal and human res…
View article: Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach
Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach Open
This study describes a novel technique to analyze the extracellular vesicle (EV)-derived microRNA (miRNA) crosstalk between equine chondrocytes and synoviocytes. Donor cells (chondrocytes, n = 8; synoviocytes, n = 9) were labelled with 5-e…
View article: Circulating miRNAs are associated with successful bone regeneration
Circulating miRNAs are associated with successful bone regeneration Open
Introduction Bone healing is a well-orchestrated process involving various bone cells and signaling pathways, where disruptions can result in delayed or incomplete healing. MicroRNAs (miRNAs) are small non-coding RNAs capable of influencin…
View article: Extracellular Vesicle-Derived MicroRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An<i> in vitro A</i>pproach
Extracellular Vesicle-Derived MicroRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An<i> in vitro A</i>pproach Open
We describe a novel technique to analyze the extracellular vesicle (EV)-derived microRNA (miRNA) crosstalk between equine chondrocytes and synoviocytes. Donor cells (chondrocytes, n=8; synoviocytes, n=9) were labelled with 5-ethynyl uridin…
View article: Raw data - Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses
Raw data - Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses Open
Raw data of the manuscript "Sepsis-Associated Acute Kidney Injury in Mice and Humans Elicits Heterogeneous Renal Microvascular MicroRNA Responses" as published in Scientific Reports (https://doi.org/10.1038/s41598-025-17319-0) are included…
View article: Exploratory miRNA profiling from serum and bone tissue of mice with T1D-induced bone loss
Exploratory miRNA profiling from serum and bone tissue of mice with T1D-induced bone loss Open
Type 1 diabetes (T1D) represents a significant health burden worldwide, with associated complications including bone fragility. Current clinical methods and biomarkers for assessing bone health and predicting fracture risk in T1D are limit…
View article: Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles
Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles Open
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as promising and safe therapeutic agents, however, donor heterogeneities, limited replicative life span and changes in the cellular phenotype throughout in vitr…
View article: P06.10.A THE MIRNA 216B-5P ACTS AS A PROMISING TUMOR-SUPPRESSOR BY MANIPULATING CELL CYCLE PROGRESSION IN HIGH-GRADE GLIOMA CELLS
P06.10.A THE MIRNA 216B-5P ACTS AS A PROMISING TUMOR-SUPPRESSOR BY MANIPULATING CELL CYCLE PROGRESSION IN HIGH-GRADE GLIOMA CELLS Open
BACKGROUND Glioblastoma is the most common brain tumor in adults and with an approximate survival rate of 15 months, new treatment strategies are of utmost urgency. In our previous phase II clinical trial, applying immunotherapy with dendr…
View article: Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification
Snorkel‐tag based affinity chromatography for recombinant extracellular vesicle purification Open
Extracellular vesicles (EVs) are lipid nanoparticles and play an important role in cell‐cell communications, making them potential therapeutic agents and allowing to engineer for targeted drug delivery. The expanding applications of EVs in…
View article: Differential microRNA expression patterns between TallyHo/JngJ mice and non-diabetic Swiss Webster Random/Jackson mice
Differential microRNA expression patterns between TallyHo/JngJ mice and non-diabetic Swiss Webster Random/Jackson mice Open
Type 2 diabetes mellitus (T2DM) increases the susceptibility of bone fragility. The underlying mechanisms have, however, remained largely unknown. MicroRNAs (miRNAs) are short single-stranded non-coding RNA molecules with utility as biomar…
View article: Candidate Signature miRNAs from Secreted miRNAome of Human Lung Microvascular Endothelial Cells in Response to Different Oxygen Conditions: A Pilot Study
Candidate Signature miRNAs from Secreted miRNAome of Human Lung Microvascular Endothelial Cells in Response to Different Oxygen Conditions: A Pilot Study Open
Oxygen conditions in the lung determine downstream organ functionality by setting the partial pressure of oxygen, regulating the redox homeostasis and by activating mediators in the lung that can be propagated in the blood stream. Examples…
View article: Longitudinal course of circulating miRNAs in a patient with hypophosphatasia and asfotase alfa treatment: a case report
Longitudinal course of circulating miRNAs in a patient with hypophosphatasia and asfotase alfa treatment: a case report Open
Hypophosphatasia (HPP) is characterized by low activity of tissue nonspecific alkaline phosphatase (TNSALP). The enzyme replacement therapy asfotase alfa has been approved for childhood-onset forms of HPP. MicroRNAs (miRNAs) have emerged a…
View article: Circulating Micro-RNAs in Patients with Hypophosphatasia Results of the first micro-RNA analysis in HPP
Circulating Micro-RNAs in Patients with Hypophosphatasia Results of the first micro-RNA analysis in HPP Open
Introduction Adult hypophosphatasia (HPP) patients present with diffuse heterogenous symptoms often mimicking rheumatological diseases or osteoporosis and therefore accompanied by delayed diagnosis. The aim of this study was to identify ci…
View article: MicroRNA expression analysis in peripheral blood and soft-tissue of patients with periprosthetic hip infection
MicroRNA expression analysis in peripheral blood and soft-tissue of patients with periprosthetic hip infection Open
Aims Current diagnostic tools are not always able to effectively identify periprosthetic joint infections (PJIs). Recent studies suggest that circulating microRNAs (miRNAs) undergo changes under pathological conditions such as infection. T…
View article: Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification
Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification Open
Extracellular vesicles (EVs) are lipid nanoparticles and play an important role in cell-cell communications, making them potential therapeutic agents and allowing to engineer for targeted drug delivery. The expanding applications of EVs in…
View article: Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden Open
In the last decade cellular senescence, a hallmark of aging, has come into focus for pharmacologically targeting aging processes. Senolytics are one of these interventive strategies that have advanced into clinical trials, creating an unme…
View article: Aged‐vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt‐axis
Aged‐vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt‐axis Open
Age‐induced decline in osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) potentiates osteoporosis and increases the risk for bone fractures. Despite epidemiology studies reporting concurrent development of vascular and bon…
View article: The plasma miRNome and venous thromboembolism in high‐grade glioma: miRNA Sequencing of a nested case–control cohort
The plasma miRNome and venous thromboembolism in high‐grade glioma: miRNA Sequencing of a nested case–control cohort Open
Patients with high‐grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non‐coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in hi…
View article: MiR-144-5p and miR-21-5p do not drive bone disease in a mouse model of type 1 diabetes mellitus
MiR-144-5p and miR-21-5p do not drive bone disease in a mouse model of type 1 diabetes mellitus Open
The increased risk of fractures in patients with type 1 diabetes mellitus (T1DM) is nowadays well recognized. However, the exact mechanism of action of diabetic bone disease has not been fully elucidated. MicroRNAs (miRNAs) are gene regula…