Matthias Heuberger
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View article: Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat
Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat Open
The wheat race-specific resistance gene Lr14a encodes an ankyrin-repeat transmembrane domain protein that confers immunity against the fungal pathogen Puccinia triticina, but the underlying mechanisms remain unclear. Here, using a range of…
View article: Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat
Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat Open
Broad-spectrum resistance genes are highly valuable for sustainable crop protection, yet the molecular basis of their activity is often unknown. The Pm3 allelic series in wheat encodes NLR receptors that recognize avirulence (AVR) effector…
View article: A reference metagenome sequence of the lichen Cladonia rangiformis
A reference metagenome sequence of the lichen Cladonia rangiformis Open
Background Lichens are an ancient symbiosis comprising the thalli of lichen-forming fungi, their photoautotrophic partners, and their microbiome. So far, they were poorly studied at the genome sequence level. Here, we present a reference m…
View article: What makes a mycoparasite? Similarities between fungi that attack other fungi and fungal and oomycete plant pathogens based on structural homology of their candidate effectors
What makes a mycoparasite? Similarities between fungi that attack other fungi and fungal and oomycete plant pathogens based on structural homology of their candidate effectors Open
Fungi that feed and thrive on other living fungi and damage those through specific adaptations to this lifestyle are known as mycoparasites. Despite its ecological significance and practical applications in crop protection, this type of pa…
View article: Interactions of Wheat Powdery Mildew Effectors Involved in Recognition by the Wheat NLR PM3
Interactions of Wheat Powdery Mildew Effectors Involved in Recognition by the Wheat NLR PM3 Open
To successfully colonize the living tissue of its host, the fungal wheat powdery mildew pathogen produces diverse effector proteins that are suggested to reprogram host defense responses and physiology. When recognized by host immune recep…
View article: An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector
An HMA-like integrated domain in the wheat tandem kinase WTK4 recognises an RNase-like pathogen effector Open
Proteins with a tandem kinase structure have recently emerged as new players in race-specific resistance in cereal crops. However, the molecular understanding of these novel immune receptors’ resistance mechanisms is limited by the lack of…
View article: k-mer-based GWAS in a wheat collection reveals novel and diverse sources of powdery mildew resistance
k-mer-based GWAS in a wheat collection reveals novel and diverse sources of powdery mildew resistance Open
Wheat genetic resources hold the diversity required to mitigate agricultural challenges from climate change and reduced inputs. Using DArTseq, we genotype 461 wheat landraces and cultivars and evaluate them for powdery mildew resistance. B…
View article: Comparative analysis of centromeres of oat ( <i>Avena sativa</i> ) and its tetraploid and diploid relatives reveals rapid evolution of centromere composition and architecture
Comparative analysis of centromeres of oat ( <i>Avena sativa</i> ) and its tetraploid and diploid relatives reveals rapid evolution of centromere composition and architecture Open
Background Recent advances in assemblies of nearly gap-free, high-quality genomes have enabled detailed analysis of centromeres in large and highly repetitive crop genomes. Here, we analyse the hexaploid Avena sativa genome and its tetrapl…
View article: Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat
Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat Open
The race-specific resistance gene Lr14a in wheat confers a unique type of heterogenous resistance reaction. It encodes an ankyrin-repeat transmembrane domain protein that confers immunity against the fungal pathogen Puccinia triticina. Her…
View article: Interactions of sequence diverse effector proteins of wheat powdery mildew control recognition specificity by the corresponding immune receptor
Interactions of sequence diverse effector proteins of wheat powdery mildew control recognition specificity by the corresponding immune receptor Open
To successfully colonize the living tissue of its host, the fungal wheat powdery mildew pathogen produces diverse effector proteins that are suggested to reprogram host defense responses and physiology. When recognized by host immune recep…
View article: A reference metagenome sequence of the lichen<i>Cladonia rangiformis</i>
A reference metagenome sequence of the lichen<i>Cladonia rangiformis</i> Open
Summary ● Lichens are an ancient symbiosis comprising the thalli of lichen-forming fungi, their photoautotrophic partners and their microbiome. So far, they were poorly studied at the genome sequence level. Here, we present a reference met…
View article: Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat
Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat Open
The race-specific resistance gene Lr14a in wheat confers a unique type of heterogenous resistance reaction. It encodes an ankyrin-repeat transmembrane domain protein that confers immunity against the fungal pathogen Puccinia triticina . He…
View article: Analysis of a global wheat panel reveals a highly diverse introgression landscape and provides evidence for inter-homoeologue chromosomal recombination
Analysis of a global wheat panel reveals a highly diverse introgression landscape and provides evidence for inter-homoeologue chromosomal recombination Open
View article: Evolution of Einkorn wheat centromeres is driven by the mutualistic interplay of two LTR retrotransposons
Evolution of Einkorn wheat centromeres is driven by the mutualistic interplay of two LTR retrotransposons Open
View article: A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance
A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance Open
View article: Analysis of a diverse wheat germplasm panel reveals a highly diverse introgression landscape and provides evidence for inter-homoeolog chromosomal recombination
Analysis of a diverse wheat germplasm panel reveals a highly diverse introgression landscape and provides evidence for inter-homoeolog chromosomal recombination Open
Agriculturally important genes are often introgressed into crops from closely related donor species or landraces. The gene pool of hexaploid bread wheat ( Triticum aestivum) is known to contain numerous such “alien” introgressions. Recentl…
View article: Dataset_MH_19_12_24
Dataset_MH_19_12_24 Open
View article: Dataset_MH_19_12_24
Dataset_MH_19_12_24 Open
View article: A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance
A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance Open
Wheat breeding for disease resistance relies on the availability and use of diverse genetic resources. More than 800,000 wheat accessions are globally conserved in gene banks, but they are mostly uncharacterized for the presence of resista…
View article: Mutagenesis of Wheat Powdery Mildew Reveals a Single Gene Controlling Both NLR and Tandem Kinase-Mediated Immunity
Mutagenesis of Wheat Powdery Mildew Reveals a Single Gene Controlling Both NLR and Tandem Kinase-Mediated Immunity Open
Blumeria graminis f. sp. tritici ( Bgt) is a globally important fungal wheat pathogen. Some wheat genotypes contain powdery mildew resistance ( Pm) genes encoding immune receptors that recognize specific fungal-secreted effector proteins, …
View article: Integration of genetic and genomics resources in einkorn wheat enables precision mapping of important traits
Integration of genetic and genomics resources in einkorn wheat enables precision mapping of important traits Open
View article: Einkorn genomics sheds light on history of the oldest domesticated wheat
Einkorn genomics sheds light on history of the oldest domesticated wheat Open
Einkorn ( Triticum monococcum ) was the first domesticated wheat species, and was central to the birth of agriculture and the Neolithic Revolution in the Fertile Crescent around 10,000 years ago 1,2 . Here we generate and analyse 5.2-Gb ge…
View article: A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance
A diverse panel of 755 bread wheat accessions harbors untapped genetic diversity in landraces and reveals novel genetic regions conferring powdery mildew resistance Open
Wheat breeding for disease resistance relies on the availability and use of diverse genetic resources. More than 800,000 wheat accessions are globally conserved in gene banks, but they are mostly uncharacterized for the presence of resista…
View article: Author Correction: Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins
Author Correction: Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins Open
View article: An online database for einkorn wheat to aid in gene discovery and functional genomics studies
An online database for einkorn wheat to aid in gene discovery and functional genomics studies Open
Diploid A-genome wheat (einkorn wheat) presents a nutrition-rich option as an ancient grain crop and a resource for the improvement of bread wheat against abiotic and biotic stresses. Realizing the importance of this wheat species, referen…
View article: Chromosome-scale genome assembly provides insights into rye biology, evolution and agronomic potential
Chromosome-scale genome assembly provides insights into rye biology, evolution and agronomic potential Open
Rye ( Secale cereale L.) is an exceptionally climate-resilient cereal crop, used extensively to produce improved wheat varieties via introgressive hybridization and possessing the entire repertoire of genes necessary to enable hybrid breed…
View article: Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins
Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins Open
View article: Chromosome-scale genome assembly provides insights into rye biology, evolution, and agronomic potential
Chromosome-scale genome assembly provides insights into rye biology, evolution, and agronomic potential Open
We present a chromosome-scale annotated assembly of the rye ( Secale cereale L. inbred line ‘Lo7’) genome, which we use to explore Triticeae genomic evolution, and rye’s superior disease and stress tolerance. The rye genome shares chromoso…
View article: Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis
Seeding Activity-Based Detection Uncovers the Different Release Mechanisms of Seed-Competent Tau Versus Inert Tau via Lysosomal Exocytosis Open
The pathological aggregation of tau characterizes a set of neurodegenerative diseases collectively referred to as tauopathies. Recent studies using cellular and animal models have suggested that tau pathology progresses by trans-cel…