Matthias Hochadel
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View article: Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry
Impact of sex on the utilization of defibrillation-capable cardiac implantable devices and outcome: results from the German device registry Open
Background and aims Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy with defibrillation-function (CRT-D) are widely used in patients with life-threatening arrhythmias or heart failure. We aim to investi…
View article: Digitalis Therapy Is Associated With an Increased Risk of <scp>ICD</scp> Shock Delivery and Device Revision
Digitalis Therapy Is Associated With an Increased Risk of <span>ICD</span> Shock Delivery and Device Revision Open
Background Digitalis glycosides are employed for rate control of atrial fibrillation and treatment of heart failure. Previous studies suggested potential harmful effects of digitalis therapy. The aim of the present study was to assess the …
View article: Pacemaker Versus Defibrillator Therapy in Patients Eligible for Cardiac Resynchronisation Therapy: Evidence from the German Device Registry
Pacemaker Versus Defibrillator Therapy in Patients Eligible for Cardiac Resynchronisation Therapy: Evidence from the German Device Registry Open
Background: According to current guidelines, cardiac resynchronisation therapy (CRT) is recommended in patients with significantly impaired left ventricular systolic function and left bundle branch block. However, the decision between pace…
View article: Ten‐Year Outcomes and Predictors of Mortality Following Catheter Ablation of Ventricular Tachycardia
Ten‐Year Outcomes and Predictors of Mortality Following Catheter Ablation of Ventricular Tachycardia Open
Background Catheter ablation is the primary treatment option for idiopathic ventricular tachycardia (VT). It plays a key role in acute therapy of electrical storm, treatment of VTs in patients with structural heart disease (SHD), and can r…
View article: Phenotypes of Patients with Direct Oral Anticoagulant (DOAC) Underdosing in Atrial Fibrillation: Results from the ARENA Registry
Phenotypes of Patients with Direct Oral Anticoagulant (DOAC) Underdosing in Atrial Fibrillation: Results from the ARENA Registry Open
NCT02978248; date of registration: 30 November 2016.
View article: Do DanGer-SHOCK-like patients benefit from VA-ECMO treatment in infarct-related cardiogenic shock? results of an individual patient data meta-analysis
Do DanGer-SHOCK-like patients benefit from VA-ECMO treatment in infarct-related cardiogenic shock? results of an individual patient data meta-analysis Open
Aims In a recent meta-analysis of randomized controlled trials, routine use of veno-arterial ECMO (VA-ECMO) did not improve outcomes in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS), while a microaxial flow p…
View article: Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project
Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project Open
View article: Procedural Outcome and 1-Year Follow-Up of Young Patients Undergoing Implantable Cardioverter–Defibrillator Implantation—Insights from the German DEVICE I+II Registry
Procedural Outcome and 1-Year Follow-Up of Young Patients Undergoing Implantable Cardioverter–Defibrillator Implantation—Insights from the German DEVICE I+II Registry Open
Background: The number of young patients receiving ICDs or CRT-Ds has been increasing in recent decades and understanding the key characteristics of this special population is paramount to optimized patient care. Methods: The DEVICE I+II r…
View article: Influence of prior myocardial infarction on outcome in patients with ischaemic HFrEF: insights from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry
Influence of prior myocardial infarction on outcome in patients with ischaemic HFrEF: insights from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry Open
Background There is scarce information about the influence of prior myocardial infarction (pMI) on outcomes in patients (pts) with ischaemic HFrEF. We analysed data from the EVIdence based TreAtment in Heart Failure (EVITA-HF) registry. Me…
View article: Mortality and rehospitalization in patients with pre-existing implantable pacemakers undergoing catheter ablation are related to increased comorbidity burden—data from the German Ablation Registry
Mortality and rehospitalization in patients with pre-existing implantable pacemakers undergoing catheter ablation are related to increased comorbidity burden—data from the German Ablation Registry Open
View article: Impact of atrial fibrillation on 1-year outcome in patients with implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator: results from the German DEVICE Registry
Impact of atrial fibrillation on 1-year outcome in patients with implantable cardioverter defibrillator or cardiac resynchronization therapy with defibrillator: results from the German DEVICE Registry Open
Our clinical data on an extended cohort of contemporary patients confirm the significant impact of AF, and its associated comorbidities, upon mortality and major adverse events after implantation of ICD/CRT.
View article: LAA occlusion is effective and safe in very high-risk atrial fibrillation patients with prior stroke: results from the multicentre German LAARGE registry
LAA occlusion is effective and safe in very high-risk atrial fibrillation patients with prior stroke: results from the multicentre German LAARGE registry Open
Background Interventional left atrial appendage occlusion (LAAO) mitigates the risk of thromboembolic events in nonvalvular atrial fibrillation (AF) patients with contraindication for long-term oral anticoagulation (OAC). Patients with pri…
View article: Generalized anxiety is a predictor of impaired quality of life in patients with atrial fibrillation: Findings from the prospective observational ARENA study
Generalized anxiety is a predictor of impaired quality of life in patients with atrial fibrillation: Findings from the prospective observational ARENA study Open
The investigators registered on ClinicalTrials.gov (NCT02978248) on November 30, 2016 https://clinicaltrials.gov/ct2/show/NCT02978248.
View article: Interventional left atrial appendage occlusion is effective and safe in high-risk patients with prior stroke: comprehensive insights from the multicenter German LAARGE registry
Interventional left atrial appendage occlusion is effective and safe in high-risk patients with prior stroke: comprehensive insights from the multicenter German LAARGE registry Open
Background Interventional left atrial appendage occlusion (LAAO) is an alternative therapeutic strategy equivalent to non-vitamin K antagonist oral anticoagulation (OAC) in preventing thromboembolism (TE) for non-valvular atrial fibrillati…
View article: Single beta-blocker or combined amiodarone therapy in ICD and CRT-D patients - Insights from the German DEVICE-registry
Single beta-blocker or combined amiodarone therapy in ICD and CRT-D patients - Insights from the German DEVICE-registry Open
Background Because of its antiarrhythmic potency and due to the lack of alternatives, amiodarone is often used for antiarrhythmic therapy in patients with ICD or CRT-D systems. To date, robust data on the safety and clinical benefit of ami…
View article: Biodegradable-Polymer or Durable-Polymer Stents in Patients at High Bleeding Risk: A Randomized, Open-Label Clinical Trial
Biodegradable-Polymer or Durable-Polymer Stents in Patients at High Bleeding Risk: A Randomized, Open-Label Clinical Trial Open
BACKGROUND: Limited information is available on the comparative efficacy and safety of different stent platforms in patients at high bleeding risk undergoing an abbreviated dual antiplatelet therapy duration after percutaneous coronary int…
View article: Cardiac defibrillator implantation in patients with syncope and inducible ventricular arrhythmia: insights from the German Device Registry
Cardiac defibrillator implantation in patients with syncope and inducible ventricular arrhythmia: insights from the German Device Registry Open
View article: Is spontaneous echo contrast associated with device-related thrombus or embolic events after left atrial appendage occlusion? - Insights from the multicenter German LAARGE registry
Is spontaneous echo contrast associated with device-related thrombus or embolic events after left atrial appendage occlusion? - Insights from the multicenter German LAARGE registry Open
View article: Amiodarone does not significantly affect the success rate of ventricular fibrillation induction tests performed during or after ICD implantation. Insights from the German DEVICE registry
Amiodarone does not significantly affect the success rate of ventricular fibrillation induction tests performed during or after ICD implantation. Insights from the German DEVICE registry Open
Funding Acknowledgements Type of funding sources: Other. Main funding source(s): The DEVICE registries were financed by “Stiftung Institut für Herzinfarktforschung (IHF)”, with additional support by grants from Biotronik, Medtronic, and St…
View article: Impact of gender on the utilization of cardiac implantable devices and outcome: results from the German DEVICE registry
Impact of gender on the utilization of cardiac implantable devices and outcome: results from the German DEVICE registry Open
Funding Acknowledgements Type of funding sources: None. Background Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) are widely used in patients with life-threatening cardiac arrhythmias or systolic…
View article: Gender-specific differences in young patients receiving implantable cardioverter-defibrillator therapy - a subgroup analysis of the german device registry
Gender-specific differences in young patients receiving implantable cardioverter-defibrillator therapy - a subgroup analysis of the german device registry Open
Funding Acknowledgements Type of funding sources: None. Background Implantable cardioverter-defibrillator (ICD) and cardiac resynchronization therapy defibrillators (CRT-D) are well established therapies in heart failure. Therapeutic and t…
View article: Cardiac defibrillator implantation in patients with syncope and inducible ventricular arrhythmia: insights from the German DEVICE registry
Cardiac defibrillator implantation in patients with syncope and inducible ventricular arrhythmia: insights from the German DEVICE registry Open
Funding Acknowledgements Type of funding sources: None. Background Programmed ventricular stimulation may be considered for risk stratification of sudden cardiac death. The history of syncope is an independent predictor for appropriate dev…
View article: The management of atrial fibrillation with oral anticoagulant drugs—an analysis of guideline adherence in the setting of the ARENA project
The management of atrial fibrillation with oral anticoagulant drugs—an analysis of guideline adherence in the setting of the ARENA project Open
View article: Correction: Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study
Correction: Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study Open
View article: Association of atrial myopathy in mitral valve disease on safety outcomes in left atrial appendage closure
Association of atrial myopathy in mitral valve disease on safety outcomes in left atrial appendage closure Open
Background Patients undergoing left atrial appendage (LAA) occlusion (LAAO) are multi-morbid, including mitral valve disease (MVD) which is associated with anatomic changes of the left atrium (LA). This study aims to identify how atrial my…
View article: Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study
Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study Open
Background Pulmonary vein isolation (PVI) is recommended to treat paroxysmal and persistent atrial fibrillation (AF). This analysis aimed to assess the hospital efficiency of single-shot cryoballoon ablation (CBA) and point-by-point radiof…
View article: Adverse events and stroke prevention by interventional left atrial appendage occlusion in patients with low CHA<sub>2</sub>DS<sub>2</sub>‐VASc score—results from the multicenter German LAARGE registry
Adverse events and stroke prevention by interventional left atrial appendage occlusion in patients with low CHA<sub>2</sub>DS<sub>2</sub>‐VASc score—results from the multicenter German LAARGE registry Open
Background Interventional left atrial appendage occlusion (LAAO) is routinely performed in patients with nonvalvular atrial fibrillation and contraindications to standard anticoagulation. Aims We investigated its role in patients at low st…
View article: Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study
Symptom Severity and Health-Related Quality of Life in Patients with Atrial Fibrillation: Findings from the Observational ARENA Study Open
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with impaired health-related quality of life (HRQoL), high symptom severity, and poor cardiovascular outcomes. Both clinical and psychol…
View article: Selection and outcome of implantable cardioverter‐defibrillator patients with and without cardiac resynchronization therapy: Comparison of 4384 patients from the German Device Registry to randomized controlled trials
Selection and outcome of implantable cardioverter‐defibrillator patients with and without cardiac resynchronization therapy: Comparison of 4384 patients from the German Device Registry to randomized controlled trials Open
Background Registry data add important information to randomized controlled trials (RCT) on real‐life aspects of implantable cardioverter‐defibrillator (ICD) patients with and without cardiac resynchronization therapy (CRT‐D). This analysi…
View article: Antiarrhythmic drug therapy after catheter ablation for atrial fibrillation—Insights from the German Ablation Registry
Antiarrhythmic drug therapy after catheter ablation for atrial fibrillation—Insights from the German Ablation Registry Open
Data on the optimal treatment strategy for antiarrhythmic drug therapy (AAD) after catheter ablation for atrial fibrillation (AF) are inconsistent. The present study investigates whether postinterventional AAD leads to an improved long‐ter…