Explanipedia

Total shoulder arthroplasty for glenohumeral osteoarthritis leads to better outcomes than hemiarthroplasty at a minimum 5 years: an intraoperative randomization-controlled trial of 79 patients Open

Norbert P. Südkamp, Martin Jaeger, Lars Adolfsson, Thomas Berndt, Michael Blauth , et al. · 2025

Background and purpose: It is unclear whether total shoulder arthroplasty (TSA) results in better outcomes in patients with degenerative shoulder diseases compared with hemiarthroplasty (HA). This randomized controlled trial (NCT01288066) …

Investigating the utilization mechanism and kinetics of sialic acid mimetics in mammalian cell lines Open

Eline A. Visser, Daniël L. A. H. Hornikx, M. Rahm, Özden Öztürk, Venetia Psomiadou , et al. · 2025

Sialic acid mimetics (SAMs) are chemically modified sialic acid derivatives that can act as metabolic inhibitors or as sugar donors for sialyltransferases.

SAT-345 High levels of circulating and monocyte-derived IL-6 in anaplastic thyroid carcinoma Open

Pepijn van Houten, Prashant Changoer, Martin Jaeger, Liesbeth van Emst, Mihai G. Netea , et al. · 2025

Disclosure: P. van Houten: None. P. Changoer: None. M. Jaeger: None. L. van Emst: None. M.G. Netea: None. H.J. Bonenkamp: None. H.H. de Wilt: None. P.B. Ottevanger: None. J.E. Walraven: None. R.T. Netea-Maier: None. Objectives: Anaplastic …

OR17-04 Reprogramming myeloid bone marrow progenitors in non-medullary thyroid cancer using trained immunity Open

Pepijn van Houten, Martin Jaeger, Prashant Changoer, Liesbeth van Emst, Willem J. M. Mulder , et al. · 2025

Disclosure: P. van Houten: None. M. Jaeger: None. P. Changoer: None. L. van Emst: None. W. Mulder: None. I.C. van Engen-van Grunsven: None. M. Bremmers: None. H.J. Bonenkamp: None. J.H. de Wilt: None. W. Hobo: None. M.G. Netea: None. R.T. …

Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer Open

Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger , et al. · 2025

Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid t…

High Local and Systemic Expression of Pentraxin-3 in Anaplastic Thyroid Cancer Open

Andreea Bojoga, Pepijn van Houten, Martin Jaeger, Katrin Rabold, Birgitte Walgreen , et al. · 2025

Background and objectives: Chronic inflammation plays a key role in cancer patho-genesis. Long pentraxin 3 (PTX3) is an inflammatory protein implicated in tumor pro-gression. Aggressive thyroid cancer is associated with immune infiltration…

Deciphering cross-cohort metabolic signatures of immune responses and their implications for disease pathogenesis Open

Jianbo Fu, Nienke van Unen, Andrei Sarlea, Nhan Nguyen, Martin Jaeger , et al. · 2025

The complex interplay between circulating metabolites and immune responses, which is pivotal to disease pathophysiology, remains poorly understood and understudied in systematic research. Here, we performed a comprehensive analysis of the …

Stabilizing Quantum-Liouville equations with complex absorbing potentials in discontinuous Galerkin frameworks Open

Valmir Ganiu, Pascal Loesing, Martin Jaeger, Dirk Schulz · 2025

Efficiently solving quantum transport equations requires numerical methods that can handle open boundary conditions while maintaining accuracy and stability. This work introduces a novel approach combining the Discontinuous Galerkin (DG) m…

Evaluation of deltoid muscle quality in reverse shoulder arthroplasty: correlation of MRI findings with postoperative function and strength Open

Balázs Bogner, Arsenij Molotkov, Martin Jaeger, Andreas Hupperich, Ferdinand C. Wagner , et al. · 2025

Objectives To evaluate associations between MRI-derived deltoid muscle parameters (areal fatty infiltration [FI] and cross-sectional area [CSA]) and clinical outcomes one year after reverse total shoulder arthroplasty (RTSA). Materials and…

Extracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer Open

Christian Grätz, Prashant Changoer, Dapi Menglin Chiang, Johannes Kersting, Martin Jaeger , et al. · 2025

Background: Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importanc…

Genetic susceptibility to recurrent vulvovaginal candidiasis in an African population from Nairobi, Kenya Open

Gloria Omosa-Manyonyi, Isis Ricaño Ponce, Diletta Rosati, Mariolina Bruno, Nelly W. Kamau , et al. · 2025

High Uptake Detection for Spinal Degenerative Changes: A Comparison Between Bone Scintigraphy and Single Photon Emission Computed Tomography Combined With High-Resolution Computed Tomography Open

Mihai Dimitriu, Robin Brugger, Nikki Rommers, Martin Jaeger, Victoria Schimmelpenning , et al. · 2025

Lactic acid in the vaginal milieu modulates the Candida -host interaction Open

Diletta Rosati, Marisa Valentine, Mariolina Bruno, Arnab Pradhan, Axel Dietschmann , et al. · 2025

Vulvovaginal candidiasis (VVC) is one of the most common infections caused by Candida albicans. VVC is characterized by an inadequate hyperinflammatory response and clinical symptoms associated with Candida colonization of th…

Prevalence of Degenerative Spinal Hot Spots on Bone Scintigraphy Among Orthopedic Patients Open

Helena Milavec, Victoria Schimmelpenning, Nikki Rommers, Mihai Dimitriu, Martin Jaeger , et al. · 2025

The study outlines the prevalence of spinal hot spots in various spinal regions among a general orthopedic population undergoing bone scans for non-spinal complaints. A strong correlation was found between spinal complaints and high uptake…

Deciphering Cross-Cohort Metabolic Signatures of Immune Responses and Their Implications for Disease Pathogenesis Open

Jianbo Fu, Nienke van Unen, Andrei Sarlea, Nhan Nguyen, Martin Jaeger , et al. · 2024

The intricate interplay between circulating metabolites and immune responses, though crucial to disease pathophysiology, remains poorly understood and underexplored in systematic research. Here, we performed a comprehensive analysis of the…

Exploring the innate immune response in polycystic liver disease Open

Renée Duijzer, Daisy Dalloyaux, Melissa M. Boerrigter, Heidi Lemmers, Helga Dijkstra , et al. · 2024

Compared to healthy controls, the PLD patients innate immune system shows an altered response when stimulated by various pathogens. These findings underscore the importance of further investigation into the underlying mechanisms as this mi…

Shape-Matching: A Novel Algorithm To Define The Optimal Reduction Endpoint In Operative Management Of Proximal Humeral Fractures (PHF) Open

Simon Lambert, П. Варга, Martin Jaeger, Karen Mys, Luke Visscher , et al. · 2024

Plasma Inflammatory Proteome Profile in a Cohort of Patients with Recurrent Vulvovaginal Candidiasis in Kenya Open

Diletta Rosati, Isis Ricaño Ponce, Gloria Omosa-Manyonyi, Mariolina Bruno, Nelly W. Kamau , et al. · 2024

Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, and up to 8% of women suffer from frequent recurrent episodes of VVC (RVVC). A lack of a protective host response underlies vaginal Candida infe…

Clavicle Shaft Non-Unions–Do We Even Need Bone Grafts? Open

Nils Mühlenfeld, Ferdinand C. Wagner, Andreas Hupperich, Lukas Heykendorf, Andreas Frodl , et al. · 2024

Background: The surgical treatment of bony non-unions is traditionally performed with additional bone grafts when atrophic and/or stronger implants when hypertrophic. In the case of the clavicle shaft, however, in our experience, a more co…

Development of an extracellular vesicle-associated transcriptomic biomarker signature for vandetanib treatment response of anaplastic thyroid cancer cells Open

Christian Grätz, Prashant Changoer, Benedikt Kirchner, Martin Jaeger, Marlene Reithmair , et al. · 2024

Anaplastic thyroid cancer (ATC) is a relatively rare but highly aggressive form of thyroid carcinoma (TC), with a median overall survival between only 3 and 6 months due to its metastatic tendency and a lack of targeted therapy options. To…

Digoxin treatment does not reinduce radioiodine uptake in radioiodine refractory non-medullary thyroid carcinoma Open

Pepijn van Houten, James Nagarajah, Janneke E. W. Walraven, Martin Jaeger, Adriana C. H. van Engen‐van Grunsven , et al. · 2024

Objective Patients with non-medullary thyroid carcinoma (NMTC) that are refractory to radioactive iodine (RAI) have a poor prognosis. Strategies for restoring the ability to take up iodine, so-called redifferentiation, are promising but no…

Targeting Signalling Modules in Thyroid Cancer Open

Prashant Changoer, Zeinab M. Mamdouh, Christian Grätz, Ana I. Casas, Martin Jaeger , et al. · 2024

Advanced thyroid cancer patients have limited treatment options and rarely result in a cure of the disease [1]. The most challenging patient groups to treat are radioiodine refractory, poorly differentiated and anaplastic thyroid cancer pa…

Development of an extracellular vesicle-associated transcriptomic biomarker signature for vandetanib treatment response of anaplastic thyroid cancer cells Open

Christian Grätz, Prashant Changoer, Benedikt Kirchner, Martin Jaeger, Marlene Reithmair , et al. · 2024

Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation Open

Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz , et al. · 2024

Our immune system possesses sophisticated mechanisms to cope with invading microorganisms, while pathogens evolve strategies to deal with threats imposed by host immunity. Human plasma protein α1-antitrypsin (AAT) exhibits pleiotropic immu…

Candida albicans N-Linked Mannans Potentiate the Induction of Trained Immunity via Dectin-2 Open

Diletta Rosati, Arnab Pradhan, Julia I. P. van Heck, Leonie Helder, Martin Jaeger , et al. · 2024

The interaction between the Candida albicans cell wall and pattern recognition receptors is crucial for the initiation of host immune responses, which, ultimately, contribute to the clearance of this pathogenic fungus. In the present study…

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses Open

Asier Fernández-Pato, Trishla Sinha, Ranko Gaćeša, Sergio Andreu‐Sánchez, Milla F. Brandao Gois , et al. · 2024

The lack of standardization in the methods of DNA extraction from fecal samples represents the major source of experimental variation in the microbiome research field. In this study, we aimed to compare the metagenomic profiles and microbi…

Common and distinct metabolomic markers related to immune aging in Western European and East African populations Open

Özlem Bulut, Godfrey S. Temba, Valerie A. C. M. Koeken, Simone J.C.F.M. Moorlag, L. Charlotte J. de Bree , et al. · 2024

In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity and mortality, and poorer vaccination efficiency. Many factors, such as genetics, diet, and lifestyle, impact aging. This study aimed to in…

IL-6 and TNF are Potential Inflammatory Biomarkers in Facioscapulohumeral Muscular Dystrophy Open

Anna Greco, Karlien Mul, Martin Jaeger, Jéssica Cristina dos Santos, Hans J. P. M. Koenen , et al. · 2024

Background: FSHD is a highly prevalent inherited myopathy with a still poorly understood pathology. Objective: To investigate whether proinflammatory cytokines are associated with FSHD and which specific innate immune cells are involved in…

11-deoxycortisol positively correlates with T cell immune traits in physiological conditions Open

Chunying Peng, Xun Jiang, Martin Jaeger, Pepijn van Houten, Antonius E. van Herwaarden , et al. · 2023

Found in acknowledgements.

Concomitant systemic inflammation and cellular immunosuppression in patients with Cushing's syndrome Open

Pepijn van Houten, Chunying Peng, Martin Jaeger, Antonius E. van Herwaarden, Mihai G. Netea , et al. · 2023

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