Matthias Löhle
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View article: Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary
Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary Open
Background Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited. Objective This study disassembled the effects of nonm…
View article: High correlation of quantitative susceptibility mapping and echo intensity measurements of nigral iron overload in Parkinson’s disease
High correlation of quantitative susceptibility mapping and echo intensity measurements of nigral iron overload in Parkinson’s disease Open
View article: Pain Fluctuations in Parkinson’s Disease and Their Association with Motor and Non-Motor Fluctuations
Pain Fluctuations in Parkinson’s Disease and Their Association with Motor and Non-Motor Fluctuations Open
Background: Pain fluctuations are a characteristic phenomenon in advanced Parkinson’s disease (PD), but their temporal association with motor and non-motor symptom (NMS) fluctuations remains largely enigmatic. Moreover, data on their impor…
View article: Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology
Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Akinetic crisis and withdrawal syndromes: guideline “Parkinson’s disease” of the German Society of Neurology
Akinetic crisis and withdrawal syndromes: guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology
Diagnostics and treatment of impulse control disorders, psychosis and delirium: systemic review-based recommendations - guideline “Parkinson’s disease” of the German Society of Neurology Open
View article: Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care
Guideline “Parkinson’s disease” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): concepts of care Open
View article: Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology)
Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology) Open
View article: Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients Open
Synucleinopathies such as Parkinson’s disease (PD) are defined by the accumulation and aggregation of the α-synuclein protein in neurons, glia and other tissues. We have previously shown that destabilization of α-synuclein tetramers is ass…
View article: The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis
The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis Open
View article: Intercultural Translation and Application of the German Version of King’s Parkinson’s Disease Pain Questionnaire in Fluctuating Parkinson’s Disease
Intercultural Translation and Application of the German Version of King’s Parkinson’s Disease Pain Questionnaire in Fluctuating Parkinson’s Disease Open
Background . Pain is common in Parkinson’s disease (PD) and impairs quality of life. The King’s PD pain questionnaire (KPPQ) is a standardized, reliable, and valid self‐administered questionnaire for screening of pain in PD. We developed a…
View article: Combining ultrasound and microelectrode recordings for postoperative localization of subthalamic electrodes in Parkinson’s disease
Combining ultrasound and microelectrode recordings for postoperative localization of subthalamic electrodes in Parkinson’s disease Open
Our method provides a new option for monitoring of STN-DBS electrode location and guidance of DBS programming in Parkinson's disease.
View article: Application of single wrist-wearable accelerometry for objective motor diary assessment in fluctuating Parkinson’s disease
Application of single wrist-wearable accelerometry for objective motor diary assessment in fluctuating Parkinson’s disease Open
Advanced Parkinson’s disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations lar…
View article: Agreement between Parkinson Disease Home Diary and Observer Assessments before and after Structured Patient Training
Agreement between Parkinson Disease Home Diary and Observer Assessments before and after Structured Patient Training Open
Objectives. Recent studies showed only fair agreement between observer and patients’ motor state assessments on the Parkinson’s disease (PD) home diary (HD). This could possibly be explained by the patients’ insufficient knowledge about mo…
View article: Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinson's Disease
Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinson's Disease Open
Background The Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers. Objective Validation of patient-reported HD by inve…
View article: Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson’s disease
Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson’s disease Open
The Parkinson’s disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the d…
View article: Motor-Independent Cognitive Testing in Motor Degenerative Diseases
Motor-Independent Cognitive Testing in Motor Degenerative Diseases Open
Cognitive function is tested through speech- or writing-based neuropsychological instruments. The application and validity of those tests is impeded for patients with diseases that affect speech and hand motor skills. We therefore develope…
View article: Functional <i>MAOB</i> Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson’s Disease
Functional <i>MAOB</i> Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson’s Disease Open
Identification of individual risk factors for motor complications in Parkinson’s disease (PD) can help to guide personalised medical treatment, particularly since treatment options are still limited. To determine whether common functional …
View article: Dissonance in Music Impairs Spatial Gait Parameters in Patients with Parkinson’s Disease
Dissonance in Music Impairs Spatial Gait Parameters in Patients with Parkinson’s Disease Open
Background: It is known that music influences gait parameters in Parkinson’s disease (PD). However, it remains unclear whether this effect is merely due to temporal aspects of music (rhythm and tempo) or other musical parameters. Objective…
View article: Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease
Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease Open
Sleep apnea and other sleep disturbances impair cognitive performance in PD and should be evaluated in routine care, and treatment options such as continuous airway pressure therapy should be considered.
View article: Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial
Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial Open
BACKGROUND Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of \\textgreeka-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits \\textgreeka-synuclein aggregat…
View article: Atrophy of the Vagus Nerve in Parkinson's Disease Revealed by High-Resolution Ultrasonography
Atrophy of the Vagus Nerve in Parkinson's Disease Revealed by High-Resolution Ultrasonography Open
Background: The vagus nerve has been suggested to represent one major route of disease progression in Parkinson's disease (PD). Here, we examined whether patients with idiopathic PD exhibit an atrophy of the vagus nerve in compariso…
View article: Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease
Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease Open
Objective : The objective of this study was to evaluate the effects of common functional polymorphisms in genes involved in dopamine metabolism on striatal dopamine turnover in de novo Parkinson's disease (PD). Methods : This was an observ…
View article: Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment
Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment Open
Background: Patients with Parkinson disease are at high risk of developing dementia. During the course of the disease, a substantial number of patients will experience a cognitive decline, indicating the dynamics of the underlying neuropat…
View article: Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson’s Disease
Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson’s Disease Open
Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient varia…
View article: Clinical prodromes of neurodegeneration in Anderson-Fabry disease
Clinical prodromes of neurodegeneration in Anderson-Fabry disease Open
Aside from cerebrovascular manifestations and small fiber neuropathy, AFD results in a distinct neurologic phenotype comprising poorer motor performance and specific nonmotor features. In contrast to functional loss of glucocerebrosidase i…