Matthias M. Herth
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View article: Initial Investigations into Nanobody Functionalization and Radiolabeling with Astatine-211
Initial Investigations into Nanobody Functionalization and Radiolabeling with Astatine-211 Open
View article: Design of innovative FAP-target modules for simultaneous delivery of CAR-T cell-and radiotherapy
Design of innovative FAP-target modules for simultaneous delivery of CAR-T cell-and radiotherapy Open
View article: Development of Theranostics Targeting the Neuropeptide Y Receptors
Development of Theranostics Targeting the Neuropeptide Y Receptors Open
View article: The Synthesis and In Vivo Evaluation of a Lysosome-Targeting Chimera for the Clearance of Bloodstream Antibodies
The Synthesis and In Vivo Evaluation of a Lysosome-Targeting Chimera for the Clearance of Bloodstream Antibodies Open
View article: Development of a stable pretargeting platform for immuno-PET imaging
Development of a stable pretargeting platform for immuno-PET imaging Open
View article: Comparison of Organometallics Towards Electrophilic Aromatic 211At-Astatinations of Tetrazines and Application in Pretargeted Therapy
Comparison of Organometallics Towards Electrophilic Aromatic 211At-Astatinations of Tetrazines and Application in Pretargeted Therapy Open
View article: Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications Open
Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 ( 211 At…
View article: Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain
Preliminary First-in-Human Pharmacokinetic Evaluation, Dosimetry and Safety of 7-[<sup>18</sup>F]-Fluorotryptophan as PET Imaging Agent to Visualize Serotonin Synthesis in the Brain Open
Tryptophan (Trp) is the precursor for serotonin synthesis and other biologically relevant metabolites. We evaluated the novel radiotracer 7-[ 18 F]Fluorotryptophan (7-[ 18 F]FTrp) to assess its biodistribution, dosimetry, and potential for…
View article: Triazole-Based Radioligands for PET of P2X<sub>7</sub>R: Syntheses, Conformational Studies, and Preliminary Autoradiographic Evaluation of <b>[<sup>18</sup>F]AM-10</b>
Triazole-Based Radioligands for PET of P2X<sub>7</sub>R: Syntheses, Conformational Studies, and Preliminary Autoradiographic Evaluation of <b>[<sup>18</sup>F]AM-10</b> Open
The P2X7 receptor is an emerging target for molecular imaging of inflammation in the brain and peripheral tissues. In this work, we focus on five triazole-based ligands with high affinity and selectivity for P2X7 rece…
View article: Synthesis and in vivo evaluation of a polar [18F]BODIPY-Tetrazine as a pretargeted bimodal imaging agent
Synthesis and in vivo evaluation of a polar [18F]BODIPY-Tetrazine as a pretargeted bimodal imaging agent Open
Fluorescence intraoperative guided surgery (FIGS) allows surgeons to resect tumors more completely - without damaging or removing healthy tissue. We have recently shown that pretargeted FIGS can improve contrast between malignances and hea…
View article: Radiofluorinated Analogs of NCS-382 as Potential PET Tracers for Imaging the CaMKIIα Hub Domain
Radiofluorinated Analogs of NCS-382 as Potential PET Tracers for Imaging the CaMKIIα Hub Domain Open
The Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a key regulator of calcium signaling in the central nervous system and is suggested to play a crucial role in neurodegenerative diseases and stroke. The CaMKIIα …
View article: Copper-mediated radiochemistry: historical impact, current trends, and future possibilities
Copper-mediated radiochemistry: historical impact, current trends, and future possibilities Open
Modern approaches to copper-mediated radiolabeling have proven an important addition to the radiochemical toolbox. Radiopharmaceuticals prepared using this methodology have been translated from preclinical PET studies into clinical trials,…
View article: How green are radiopharmaceutical sciences?
How green are radiopharmaceutical sciences? Open
The rapid growth of radiopharmaceutical sciences, driven by regulatory approvals of theranostic agents and the expanding role of PET imaging, underscores the need for sustainable and green practices. While radiopharmaceuticals offer high p…
View article: Head-to-Head Comparison of the <i>in Vivo</i> Performance of Highly Reactive and Polar <sup>18</sup>F-Labeled Tetrazines
Head-to-Head Comparison of the <i>in Vivo</i> Performance of Highly Reactive and Polar <sup>18</sup>F-Labeled Tetrazines Open
Pretargeted imaging harnessing tetrazine ligation has gained increased interest over recent years. Targeting vectors with slow pharmacokinetics may be visualized using short-lived radionuclides, such as fluorine-18 (18F) for pos…
View article: Solid-phase supported direct 18F-radiofluorination of peptides
Solid-phase supported direct 18F-radiofluorination of peptides Open
The absence of universal and expedient labeling procedures hampers the widespread application of peptides as molecular tracers for positron emission tomography (PET). In this work, we have developed a proof-of-concept direct radiofluorinat…
View article: Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor
Development of β-arrestin biased positron emission tomography radioligands for the cerebral serotonin 2A receptor Open
View article: Comparison of Different Organometallics Towards Electrophilic Aromatic <sup>211</sup>At‐Astatinations of Highly Reactive Tetrazines
Comparison of Different Organometallics Towards Electrophilic Aromatic <sup>211</sup>At‐Astatinations of Highly Reactive Tetrazines Open
Organometallics can be used as precursors for electrophilic 211 At‐statinations. In this report, we compared the potential of aryl trimethylsilanes, ‐germanes, or –stannanes to be used as precursors to 211 At‐label highly reactive tetrazin…
View article: Brain Pretargeted PET – New Horizons to Image CNS Targets with Monoclonal Antibodies
Brain Pretargeted PET – New Horizons to Image CNS Targets with Monoclonal Antibodies Open
Antibodies are excellent targeting vectors for molecular imaging. Slow pharmacokinetics and low blood-brain barrier penetration hinder their widespread application for molecular imaging within CNS. Improved brain uptake can be achieved via…
View article: Development of Polar BODIPY-Tetrazines for Rapid Pretargeted Fluorescence Imaging
Development of Polar BODIPY-Tetrazines for Rapid Pretargeted Fluorescence Imaging Open
Polar BODIPY-tetrazine dyes were developed and clicked in vivo to a preaccumulated trans-cyclooctene-modified anti-TAG72 monoclonal antibody CC49 (CC49-TCO). The in vivo click performance was evaluated using an in-house developed ex…
View article: [68Ga]Ga-DOTAGA-Glu(FAPi)2 Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging
[68Ga]Ga-DOTAGA-Glu(FAPi)2 Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging Open
The use of fibroblast activation protein inhibitors (FAPis) for positron emission tomography (PET) imaging in cancer has garnered significant interest in recent years, yielding promising results in preclinical and clinical settings. FAP is…
View article: Rapid Electrophilic <sup>211</sup>At‐Astatination of Trimethylgermyl Arenes
Rapid Electrophilic <sup>211</sup>At‐Astatination of Trimethylgermyl Arenes Open
A set of 211 At‐astatoarenes were synthesized from corresponding trimethylgermyl arenes with an average radiochemical conversion (RCC) of ca. 50 % for electron‐rich and approx. 70 % in case of electron‐deficient arenes. Both electron rich …
View article: Not all serotonergic psychedelics are alike - they induce distinct patterns of altered metabolic activity and connectivity
Not all serotonergic psychedelics are alike - they induce distinct patterns of altered metabolic activity and connectivity Open
Serotonergic psychedelic drugs have shown promising benefits in trials for various neuropsychiatric disorders. While the acute effects of these psychedelics last only a few hours, the positive therapeutic effects can persist long after a s…
View article: Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging Open
Background: The development of bispecific antibodies that can traverse the blood–brain barrier has paved the way for brain-directed immunotherapy and when radiolabelled, immunoPET imaging. The objective of this study was to investigate how…
View article: Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model
Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model Open
Pretargeting, which is the separation of target accumulation and the administration of a secondary imaging agent into two sequential steps, offers the potential to improve image contrast and reduce radiation burden for nuclear imaging. In …
View article: Investigation of imaging the somatostatin receptor by opening the blood-brain barrier with melittin – A feasibility study using positron emission tomography and [64Cu]Cu-DOTATATE
Investigation of imaging the somatostatin receptor by opening the blood-brain barrier with melittin – A feasibility study using positron emission tomography and [64Cu]Cu-DOTATATE Open
DOTATATE is a somatostatin peptide analog used in the clinic to detect somatostatin receptors which are highly expressed on neuroendocrine tumors. Somatostatin receptors are found naturally in the intestines, pancreas, lungs, and brain (ma…
View article: Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET Open
Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based ligands through the blood–brain barrier (BBB). To overcome this physiological o…
View article: Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET
Synthesis and evaluation of fluorine-18 labelled tetrazines as pre-targeting imaging agents for PET Open
Background The brain is a challenging target for antibody-based positron emission tomography (immunoPET) imaging due to the restricted access of antibody-based ligands through the blood-brain barrier (BBB). To overcome this physiological o…
View article: A facile synthesis of precursor for the σ‐1 receptor PET radioligand [<sup>18</sup>F]FTC‐146 and its radiofluorination
A facile synthesis of precursor for the σ‐1 receptor PET radioligand [<sup>18</sup>F]FTC‐146 and its radiofluorination Open
The σ‐1 receptor is a non‐opioid transmembrane protein involved in various human pathologies including neurodegenerative diseases, inflammation, and cancer. The previously published ligand [ 18 F]FTC‐146 is among the most promising tools f…
View article: Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine
Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging. Comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine Open
View article: Editorial: Prof. Frank Rösch's legacy in the radiopharmaceutical chemistry field
Editorial: Prof. Frank Rösch's legacy in the radiopharmaceutical chemistry field Open
EDITORIAL article Front. Nucl. Med., 27 November 2023Sec. Radiopharmacy and Radiochemistry Volume 3 - 2023 | https://doi.org/10.3389/fnume.2023.1336481