Matthias Majetschak
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View article: Activation of Chemokine (C‐C Motif) Receptor 1 Modulates α <sub>1B</sub> ‐Adrenoceptor and Arginine Vasopressin Receptor 1A Signaling and Function
Activation of Chemokine (C‐C Motif) Receptor 1 Modulates α <sub>1B</sub> ‐Adrenoceptor and Arginine Vasopressin Receptor 1A Signaling and Function Open
Background We reported previously that α 1B ‐AR (α 1B ‐adrenoceptor) and AVPR1A (arginine vasopressin receptor 1A) heteromerize with CCR1 (C‐C motif [chemokine] receptor 1) in human monocytes, through which CCR1 is controlled. Whether CCR1…
View article: The Chemokine (C-C Motif) Receptor 1 Antagonist BX471 Improves Fluid Resuscitation in Rat Models of Hemorrhagic Shock
The Chemokine (C-C Motif) Receptor 1 Antagonist BX471 Improves Fluid Resuscitation in Rat Models of Hemorrhagic Shock Open
Background/Objectives: We reported previously that antagonists at chemokine receptors CCR2 and CCR3 have fluid-sparing effects during resuscitation from hemorrhagic shock. Because CCR1 shares several chemokine ligands with CCR2/3, we teste…
View article: β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock
β-Adrenoceptor Agonists Attenuate Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function and Protect the Lung Vascular Barrier during Resuscitation from Hemorrhagic Shock Open
β-adrenoceptor (β-AR) agonists are known to antagonize thrombin-induced impairment (TII) of bovine and ovine lung endothelial barrier function. The effects of adrenoceptor agonists and other vasoactive agents on human lung microvascular en…
View article: Chemokine receptor hetero-oligomers regulate monocyte chemotaxis
Chemokine receptor hetero-oligomers regulate monocyte chemotaxis Open
It is known that stress influences immune cell function. The underlying molecular mechanisms are unclear. We recently reported that many chemokine receptors (CRs) heteromerize with α 1 -adrenoceptors (α 1 -ARs) through which CRs are regula…
View article: G protein activation <i>via</i> chemokine (<scp>C‐X‐C</scp> motif) receptor 4 and α<sub>1b</sub>‐adrenoceptor is ligand and heteromer‐dependent
G protein activation <i>via</i> chemokine (<span>C‐X‐C</span> motif) receptor 4 and α<sub>1b</sub>‐adrenoceptor is ligand and heteromer‐dependent Open
It is unknown whether heteromerization between chemokine (C‐X‐C motif) receptor 4 (CXCR4), atypical chemokine receptor 3 (ACKR3) and α 1b ‐adrenoceptor (α 1b ‐AR) influences effects of the CXCR4/ACKR3 agonist chemokine (C‐X‐C motif) ligand…
View article: Effects of chemokine (C-C motif) receptor 2 and 3 antagonists in rat models of hemorrhagic shock
Effects of chemokine (C-C motif) receptor 2 and 3 antagonists in rat models of hemorrhagic shock Open
Systemic concentrations of chemokine CCL2, an agonist at chemokine receptors CCR2/3/5, have been associated with hemodynamic instability after traumatic-hemorrhagic shock. We reported previously that the CCR2 antagonist INCB3284 prevents c…
View article: α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation
α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation Open
View article: Weche et al minimal data set.xlsx
Weche et al minimal data set.xlsx Open
Minial data set for Weche et al, PLOS One, 2023
View article: Heteromerization between <scp>α<sub>1B</sub></scp>‐adrenoceptor and chemokine (<scp>C‐C</scp> motif) receptor 2 biases <scp>α<sub>1B</sub></scp>‐adrenoceptor signaling: Implications for vascular function
Heteromerization between <span>α<sub>1B</sub></span>‐adrenoceptor and chemokine (<span>C‐C</span> motif) receptor 2 biases <span>α<sub>1B</sub></span>‐adrenoceptor signaling: Implications for vascular function Open
Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α 1B ‐adrenoceptor (α 1B ‐AR) in leukocytes, through which α 1B ‐AR controls CCR2. Whether such heteromers are expressed in human vascular smooth muscl…
View article: α<sub>1B/D</sub>-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes
α<sub>1B/D</sub>-adrenoceptors regulate chemokine receptor–mediated leukocyte migration via formation of heteromeric receptor complexes Open
Significance Here we show that most chemokine receptors (CRs) form heteromeric complexes with α 1 -adrenergic receptors (ARs) in recombinant systems and that such heteromers are detectable in human monocytes and in the human monocytic leuk…
View article: The Chemokine (C-C Motif) Receptor 2 Antagonist INCB3284 Reduces Fluid Requirements and Protects From Hemodynamic Decompensation During Resuscitation From Hemorrhagic Shock
The Chemokine (C-C Motif) Receptor 2 Antagonist INCB3284 Reduces Fluid Requirements and Protects From Hemodynamic Decompensation During Resuscitation From Hemorrhagic Shock Open
OBJECTIVES: Clinical correlations suggest that systemic chemokine (C-C motif) ligand (CCL) 2 release may contribute to blood pressure regulation and the development of hemodynamic instability during the early inflammatory response to traum…
View article: Linopirdine-supplemented resuscitation fluids reduce mortality in a model of ischemia-reperfusion injury induced acute respiratory distress syndrome
Linopirdine-supplemented resuscitation fluids reduce mortality in a model of ischemia-reperfusion injury induced acute respiratory distress syndrome Open
reperfusion and fluid resuscitation to a mean arterial blood pressure of 60 mmHg with normal saline (NS, n=9) or NS supplemented with 50 µg/ml linopridine (NS-L), n=7) until t=360 min. As compared with NS, fluid resuscitation with NS-L sta…
View article: Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells
Plasticity of seven-transmembrane-helix receptor heteromers in human vascular smooth muscle cells Open
Recently, we reported that the chemokine (C-X-C motif) receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) heteromerize with α 1A/B/D -adrenoceptors (ARs) and arginine vasopressin receptor 1A (AVPR1A) in recombinant systems and in…
View article: Chemokine receptor antagonists with α<sub>1</sub>-adrenergic receptor blocker activity
Chemokine receptor antagonists with α<sub>1</sub>-adrenergic receptor blocker activity Open
Objectives Chemokine receptor antagonists are being explored for their therapeutic potential in various disease processes. As the chemokine (C–C motif) receptor 2 (CCR2) antagonist RS504393 is known to compete with ligand binding to α 1 -a…
View article: Class A G protein‐coupled receptors assemble into functional higher‐order hetero‐oligomers
Class A G protein‐coupled receptors assemble into functional higher‐order hetero‐oligomers Open
Although class A seven‐transmembrane helix (7TM) receptor hetero‐oligomers have been proposed, information on the assembly and function of such higher‐order hetero‐oligomers is not available. Utilizing bioluminescence resonance energy tran…
View article: Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (CXC motif) receptor 4
Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (CXC motif) receptor 4 Open
The chemokine receptor CXCR4, a G protein-coupled receptor (GPCR) capable of heteromerizing with other GPCRs, is involved in many processes, including immune responses, hematopoiesis, and organogenesis. Evidence suggests that CXCR4 activat…
View article: Natural and engineered chemokine (C-X-C motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia–reperfusion injury and hemorrhage
Natural and engineered chemokine (C-X-C motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia–reperfusion injury and hemorrhage Open
We compared therapeutic properties of natural and engineered chemokine (C-X-C motif) receptor 4 (CXCR4) agonists in a rat acute respiratory distress syndrome (ARDS) model utilizing the PaO 2 /FiO 2 -ratio as a clinically relevant primary o…
View article: Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays
Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays Open
View article: Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings
Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings Open
On August 27 and 28, 2018, the American Burn Association, in conjunction with Underwriters Laboratories, convened a group of experts on burn and inhalation injury in Washington, DC. The goal of the meeting was to identify and discuss the e…
View article: Effects of ethanol and ethanol metabolites on intrinsic function of mesenteric resistance arteries
Effects of ethanol and ethanol metabolites on intrinsic function of mesenteric resistance arteries Open
Evidence suggests that ethanol-induced hypertension is associated with increased cardiovascular responsiveness to vasopressors in vivo and enhanced reactivity of isolated arteries to vasopressors ex vivo. The underlying mechanisms are not …
View article: Chemokine (C-X-C motif) receptor 4 regulates lung endothelial barrier permeability during resuscitation from hemorrhagic shock
Chemokine (C-X-C motif) receptor 4 regulates lung endothelial barrier permeability during resuscitation from hemorrhagic shock Open
Chemokine (C-X-C motif) receptor 4 (CXCR4) agonists have been shown to protect lung endothelial barrier function in vitro. In vivo effects of CXCR4 modulation on lung endothelial permeability are unknown. Here we tested the effects of the …
View article: Biased antagonism of CXCR4 avoids antagonist tolerance
Biased antagonism of CXCR4 avoids antagonist tolerance Open
Selectively blocking G protein signaling but not GPCR internalization may provide therapeutic benefit.
View article: Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3
Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 Open
We observed in PRESTO-Tango β-arrestin recruitment assays that the α1-adrenergic receptor (AR) antagonist prazosin activates chemokine (C-X-C motif) receptor (CXCR)4. This prompted us to further examine this unexpected pharmacological beha…
View article: Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex
Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C motif) receptor 4 by α1-adrenergic receptors at the heteromeric receptor complex Open
View article: Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle
Identification and functional characterization of arginine vasopressin receptor 1A : atypical chemokine receptor 3 heteromers in vascular smooth muscle Open
Recent observations suggest that atypical chemokine receptor (ACKR)3 and chemokine (C-X-C motif) receptor (CXCR)4 regulate human vascular smooth muscle function through hetero-oligomerization with α 1 -adrenoceptors. Here, we show that ACK…
View article: Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function
Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function Open
Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function. A detailed characterization of the effects of CXCL12 on throm…
View article: Pharmacological modulation of C‐X‐C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischaemia–reperfusion injury
Pharmacological modulation of C‐X‐C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischaemia–reperfusion injury Open
Summary Activation of C‐X‐C motif chemokine receptor 4 (CXCR4) has been reported to result in lung protective effects in various experimental models. The effects of pharmacological CXCR4 modulation on the development of acute respiratory d…
View article: α<sub>1</sub>‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells
α<sub>1</sub>‐Adrenergic Receptors Function Within Hetero‐Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C‐X‐C motif) Receptor 4 in Vascular Smooth Muscle Cells Open
Background Recently, we provided evidence that α 1 ‐adrenergic receptors ( ARs ) in vascular smooth muscle are regulated by chemokine (C‐X‐C motif) receptor ( CXCR ) 4 and atypical chemokine receptor 3 ( ACKR 3). While we showed that CXCR …
View article: Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists
Functional and structural consequences of chemokine (C-X-C motif) receptor 4 activation with cognate and non-cognate agonists Open
View article: Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats
Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats Open
Our data suggest that Kv7 channel blockers could be used to stabilize blood pressure and reduce fluid resuscitation requirements after hemorrhagic shock.