Matthias J.P. van Osch
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View article: In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy
In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy Open
Leakage of gadolinium-based contrast agent through the BBB can be measured in vivo in CAA from the leptomeningeal vessels, and findings point to likely leakage from cortical small vessels as well. Leakage from leptomeningeal vessels was as…
View article: The association between cerebral “dirty-appearing” white matter and progression of small vessel disease in community-dwelling older adults
The association between cerebral “dirty-appearing” white matter and progression of small vessel disease in community-dwelling older adults Open
Cerebral “dirty-appearing” white matter (DAWM) may represent early white matter alterations linked to cerebral small vessel disease (cSVD), though its role in cSVD progression is unclear. Therefore, DAWM prevalence and associations with cS…
View article: Insights Into CEST Contrast at 2 ppm in Enhancing and Nonenhancing Lesions From Glioma Patients Scanned at 7 T
Insights Into CEST Contrast at 2 ppm in Enhancing and Nonenhancing Lesions From Glioma Patients Scanned at 7 T Open
Introduction Chemical exchange saturation transfer (CEST) has been demonstrated to provide a noninvasive opportunity to image gliomas. Preclinical ultrahigh‐field MRI studies have shown the value of the 2 ppm pool; however, in vivo studies…
View article: Hyperintense lesions suspect for acute cerebral microbleeds on ultra-high field T1 weighted 7 Tesla MRI in patients with cerebral amyloid angiopathy
Hyperintense lesions suspect for acute cerebral microbleeds on ultra-high field T1 weighted 7 Tesla MRI in patients with cerebral amyloid angiopathy Open
7 T T1 hyperintense lesions were identified in approximately one in ten patients in our cohort. Acute CMBs were more often identified on 7 T MRI in comparison to 3 T MRI. This highlights the additional value of ultra-high field MRI in the …
View article: Hybrid Multidelay PCASL Acquired With Time‐Encoded and Variable‐TR Schemes for the Assessment of Cerebral Perfusion in Moyamoya Disease
Hybrid Multidelay PCASL Acquired With Time‐Encoded and Variable‐TR Schemes for the Assessment of Cerebral Perfusion in Moyamoya Disease Open
Multidelay arterial spin labeling (ASL) MRI requires balancing temporal information with signal‐to‐noise ratio (SNR). A hybrid scheme combines the high SNR of time‐encoded pseudo‐continuous ASL (PCASL) with the temporal flexibility of vari…
View article: Navigator‐free multi‐shot diffusion <scp>MRI</scp> via non‐local low‐rank reconstruction
Navigator‐free multi‐shot diffusion <span>MRI</span> via non‐local low‐rank reconstruction Open
Purpose To develop a non‐local low‐rank (NLLR) reconstruction method for multi‐shot EPI (ms‐EPI) in DWI, addressing phase inconsistencies and noise issues while maintaining high spatial resolution in clinically feasible scan times. Theory …
View article: One-Year Radiologic Progression in Sporadic and Hereditary Cerebral Amyloid Angiopathy
One-Year Radiologic Progression in Sporadic and Hereditary Cerebral Amyloid Angiopathy Open
CAA is a radiologically progressive disease even in the short-term. After 1 year, all symptomatic and most of the presymptomatic participants showed progression of at least 1 MRI-marker. CMBs and WMH volume (in symptomatic CAA) and WMH vol…
View article: A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults
A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults Open
WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults. The current study aimed to investigate the association of WMH shape and decline in three cognitive domains over five years' time in…
View article: <scp>MRI</scp> ‐based surrogates of brain clearance in narcolepsy type 1
<span>MRI</span> ‐based surrogates of brain clearance in narcolepsy type 1 Open
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate meas…
View article: Rapid quantitative <scp>MRI</scp> at 46 <scp>mT</scp> : Accelerated <scp> T <sub>1</sub> </scp> and <scp> T <sub>2</sub> </scp> mapping with low‐rank reconstructions
Rapid quantitative <span>MRI</span> at 46 <span>mT</span> : Accelerated <span> T <sub>1</sub> </span> and <span> T <sub>2</sub> </span> mapping with low‐rank reconstructions Open
Purpose To evaluate accelerated T 1 ‐ and T 2 ‐mapping techniques for ultra–low‐field MRI using low‐rank reconstruction methods. Methods Two low‐rank–based algorithms, image‐based locally low‐rank (LLR) and k‐space–based structured low‐ran…
View article: Extension of T<sub>2</sub> Hyperintense Areas in Patients With a Glioma: A Comparison Between High‐Quality 7 T MRI and Clinical Scans
Extension of T<sub>2</sub> Hyperintense Areas in Patients With a Glioma: A Comparison Between High‐Quality 7 T MRI and Clinical Scans Open
Gliomas are highly heterogeneous and often include a nonenhancing component that is hyperintense on T 2 weighted MRI. This can often not be distinguished from secondary gliosis and surrounding edema. We hypothesized that the extent of thes…
View article: Noninvasive blood–brain barrier integrity mapping in patients with high‐grade glioma and metastasis by multi–echo time–encoded arterial spin labeling
Noninvasive blood–brain barrier integrity mapping in patients with high‐grade glioma and metastasis by multi–echo time–encoded arterial spin labeling Open
Purpose In brain tumors, disruption of the blood–brain barrier (BBB) indicates malignancy. Clinical assessment is qualitative; quantitative evaluation is feasible using the K 2 leakage parameter from dynamic susceptibility contrast MRI. Ho…
View article: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial
The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial Open
Aerobic exercise may improve cerebral perfusion and may thereby attenuate, or delay, cognitive decline. Excersion-VCI aimed to evaluate the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment (VC…
View article: Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks
Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks Open
Recent advancements in MRI hardware, including ultra-high magnetic field scanners (≥7T) and MR data acquisition methods, have enhanced functional imaging techniques, allowing for the detailed study of brain function, particularly at the me…
View article: The Road to a Realistic 3D Model for Estimating <i>R</i><sub>2</sub> and <i>R</i><sub>2</sub>* Relaxation Versus Gd‐DTPA Concentration in Whole Blood and Brain Tumor Vasculature
The Road to a Realistic 3D Model for Estimating <i>R</i><sub>2</sub> and <i>R</i><sub>2</sub>* Relaxation Versus Gd‐DTPA Concentration in Whole Blood and Brain Tumor Vasculature Open
Dynamic susceptibility contrast (DSC) MRI is commonly part of brain tumor imaging. For quantitative analysis, measurement of the arterial input function and tissue concentration time curve is required. Usually, a linear relationship betwee…
View article: Unmasking early cerebral blood flow alterations with time‐encoded ASL in Alzheimer's continuum
Unmasking early cerebral blood flow alterations with time‐encoded ASL in Alzheimer's continuum Open
Background Arterial spin labelling (ASL) is a non‐invasive MRI technique for quantifying cerebral blood flow (CBF), used for monitoring changes over the course of a disease or treatment. A crucial parameter in ASL is the post‐labelling del…
View article: Exploring the need for a preload on the estimation of permeability, vessel radius, and relative cerebral blood volume in <scp>MR</scp> vascular fingerprinting–based dynamic susceptibility contrast perfusion imaging
Exploring the need for a preload on the estimation of permeability, vessel radius, and relative cerebral blood volume in <span>MR</span> vascular fingerprinting–based dynamic susceptibility contrast perfusion imaging Open
Purpose Dynamic susceptibility contrast (DSC) MRI is commonly part of the clinical brain tumor imaging protocol. Usually, a preload of contrast agent is administered to minimize contrast‐leakage T 1 effects. However, recent studies have in…
View article: Anti-Platelet IgG-Fc Glycosylation As a Novel Regulator in Platelet Transfusion Refractoriness
Anti-Platelet IgG-Fc Glycosylation As a Novel Regulator in Platelet Transfusion Refractoriness Open
Platelet transfusion refractoriness (PTR) is a major clinical burden that remains challenging and very costly to manage. While platelet transfusions significantly reduce mortality in patients with thrombocytopenia, in approximately 5-15% o…
View article: BOLD-CSF dynamics assessed using real time phase contrast CSF flow interleaved with cortical BOLD MRI
BOLD-CSF dynamics assessed using real time phase contrast CSF flow interleaved with cortical BOLD MRI Open
Background: Cerebrospinal fluid (CSF) motion and pulsatility has been proposed to play a crucial role in clearing brain waste. Although its driving forces remain debated, increasing evidence suggests that large amplitude vasomotion drives …
View article: MRI-based surrogates of brain clearance in narcolepsy type 1
MRI-based surrogates of brain clearance in narcolepsy type 1 Open
Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI-based methods attempt to approximate human brain clearance with surrogate measures. Th…
View article: Region specific drivers of cerebrospinal fluid mobility as measured by high-resolution non-invasive MRI in humans
Region specific drivers of cerebrospinal fluid mobility as measured by high-resolution non-invasive MRI in humans Open
Highlights CSF-mobility can be measured in humans down to the level of perivascular spaces surrounding penetrating vessels using CSF-STREAM In perivascular spaces surrounding penetrating vessels, the cardiac and respiratory cycles have sim…
View article: Perfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice
Perfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice Open
Background Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study exa…
View article: Chemical shift–encoded multishot <scp>EPI</scp> for navigator‐free prostate DWI
Chemical shift–encoded multishot <span>EPI</span> for navigator‐free prostate DWI Open
Purpose DWI is an important contrast for prostate MRI to enable early and accurate detection of cancer. This study introduces a Dixon 3‐shot‐EPI protocol with structured low‐rank reconstruction for navigator‐free DWI. The aim is to overcom…
View article: Cognition in (pre)symptomatic Dutch‐type hereditary and sporadic cerebral amyloid angiopathy
Cognition in (pre)symptomatic Dutch‐type hereditary and sporadic cerebral amyloid angiopathy Open
INTRODUCTION Cerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association…
View article: A Plug-and-Play Method for Guided Multi-contrast MRI Reconstruction based on Content/Style Modeling
A Plug-and-Play Method for Guided Multi-contrast MRI Reconstruction based on Content/Style Modeling Open
Since multiple MRI contrasts of the same anatomy contain redundant information, one contrast can guide the reconstruction of an undersampled subsequent contrast. To this end, several end-to-end learning-based guided reconstruction methods …