Philippe Hubert
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View article: Updating of Quantitative Models in Validation and Routine Tests of Comparative Chemical Methods
Updating of Quantitative Models in Validation and Routine Tests of Comparative Chemical Methods Open
Nowadays, health and safety requirements are becoming more urgent, through normative and regulatory texts, considering the intense demands of customers from the different sectors of socio-economic activities. Chemical testing must undoubte…
View article: N-nitrosamine risk assessment in pharmaceuticals: Where are we from a regulatory point of view in 2025?
N-nitrosamine risk assessment in pharmaceuticals: Where are we from a regulatory point of view in 2025? Open
View article: Innovative QSRR modeling approach for the development of an ultra-sensitive LC-MS/MS method for trace analysis of N-nitrosamines
Innovative QSRR modeling approach for the development of an ultra-sensitive LC-MS/MS method for trace analysis of N-nitrosamines Open
peer reviewed
View article: Is surface-enhanced Raman spectroscopy (SERS) a good alternative to separation techniques for nicotine dosage in e-liquid boosters?
Is surface-enhanced Raman spectroscopy (SERS) a good alternative to separation techniques for nicotine dosage in e-liquid boosters? Open
peer reviewed
View article: Determination of Size, Size Distribution, and Concentration of Nanoparticles Using ICP‐MS in the Context of SERS Substrates
Determination of Size, Size Distribution, and Concentration of Nanoparticles Using ICP‐MS in the Context of SERS Substrates Open
Surface enhanced Raman scattering (SERS) is a widely used vibrational spectroscopic technique employing metallic nanostructures to enhance an inherent Raman signal. This study aimed to develop a method for the characterization of SERS subs…
View article: Surface enhanced transmission Raman spectroscopy: Quantitative performances for impurity analysis in complex matrices
Surface enhanced transmission Raman spectroscopy: Quantitative performances for impurity analysis in complex matrices Open
View article: Hydrodynamic injection for microchip electrophoresis: Development of an innovative passive system
Hydrodynamic injection for microchip electrophoresis: Development of an innovative passive system Open
The world is facing challenges in terms of environmental sustainability and rising costs. In this context, miniaturized equipment such as microfluidic devices can be used to manipulate small volumes of fluids in micrometer-sized channels i…
View article: Optimisation of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve SERS Analytical Performances
Optimisation of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve SERS Analytical Performances Open
A major limitation preventing the use of surface-enhanced Raman scattering (SERS) in routine analyses is the signal variability due to the heterogeneity of metallic nanoparticles used as SERS substrates. This study aimed to robustly optimi…
View article: Uncertainty management for In Silico screening of reversed-phase liquid chromatography methods for small compounds
Uncertainty management for In Silico screening of reversed-phase liquid chromatography methods for small compounds Open
View article: Challenges in the most challenging course as perceived by the students of health sciences during the Covid‐19 pandemic: What are they and who were struggling the most?
Challenges in the most challenging course as perceived by the students of health sciences during the Covid‐19 pandemic: What are they and who were struggling the most? Open
The immediate shift to remote teaching or distance learning, due to COVID‐19 management strategies, most notably limited in‐person contact, was abruptly implemented in universities worldwide. This process was demanding for both the instruc…
View article: The Removal of As(III) Using a Natural Laterite Fixed-Bed Column Intercalated with Activated Carbon: Solving the Clogging Problem to Achieve Better Performance
The Removal of As(III) Using a Natural Laterite Fixed-Bed Column Intercalated with Activated Carbon: Solving the Clogging Problem to Achieve Better Performance Open
Natural laterite fixed-bed columns intercalated with two types of layers (inert materials, such as fine sand and gravel, and adsorbent materials, such as activated carbon prepared from Balanites aegyptiaca (BA-AC)) were used for As(III) re…
View article: Optimization of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve Sers Analytical Performances
Optimization of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve Sers Analytical Performances Open
View article: Determination of Size, Size Distribution and Concentration of Nanoparticles Using Icp-Ms in the Context of Sers Substrates
Determination of Size, Size Distribution and Concentration of Nanoparticles Using Icp-Ms in the Context of Sers Substrates Open
View article: Optimization of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve Sers Analytical Performances
Optimization of a Microwave Synthesis of Silver Nanoparticles by a Quality by Design Approach to Improve Sers Analytical Performances Open
View article: Surface Enhanced Transmission Raman Spectroscopy: Quantitative Performances for Impurity Analysis in Complex Matrices
Surface Enhanced Transmission Raman Spectroscopy: Quantitative Performances for Impurity Analysis in Complex Matrices Open
View article: Hydrodynamic Injection for Microchip Electrophoresis:Development of an Innovative Passive System
Hydrodynamic Injection for Microchip Electrophoresis:Development of an Innovative Passive System Open
View article: In-Field Implementation of Near-Infrared Quantitative Methods for Analysis of Medicines in Tropical Environments
In-Field Implementation of Near-Infrared Quantitative Methods for Analysis of Medicines in Tropical Environments Open
Near-infrared (NIR) spectroscopy is actually a well-established technique that demonstrates its performance in the frame of detection of poor-quality medicines. The use of low-cost handheld NIR spectrophotometers in low-resource contexts c…
View article: Removal of As(III) Using a Natural Laterite Fixed-Bed Column Intercalated with Activated Carbon: Solving the Clogging Problem to Achieve Better Performance
Removal of As(III) Using a Natural Laterite Fixed-Bed Column Intercalated with Activated Carbon: Solving the Clogging Problem to Achieve Better Performance Open
Natural laterite fixed-bed column intercalated with activated carbon prepared from Balanites ae-gyptiaca (BA-AC) was used for As(III) removal from an aqueous solution. Investigations were carried out to solve the problem of column clogging…
View article: Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance
Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance Open
The negative consequences of Substandard and falsified (SF) medicines are widely documented nowadays and there is still an urgent need to find them in more efficient ways. Several screening tools have been developed for this purpose recent…
View article: Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice
Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice Open
In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocar…
View article: Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: Early characterization using the quality by design approach
Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: Early characterization using the quality by design approach Open
View article: Quantitative Structure Retention-Relationship Modeling: Towards an Innovative General-Purpose Strategy
Quantitative Structure Retention-Relationship Modeling: Towards an Innovative General-Purpose Strategy Open
Reversed-Phase Liquid Chromatography (RPLC) is a common liquid chromatographic mode used for the control of pharmaceutical compounds during their drug life cycle. Nevertheless, determining the optimal chromatographic conditions that enable…
View article: Readedtest: A Tool to Assess the Readiness of in Vitro Test Methods Under Development for Identifying Endocrine Disruptors
Readedtest: A Tool to Assess the Readiness of in Vitro Test Methods Under Development for Identifying Endocrine Disruptors Open
View article: Prevalence of Poor Quality Ciprofloxacin and Metronidazole Tablets in Three Cities in Cameroon
Prevalence of Poor Quality Ciprofloxacin and Metronidazole Tablets in Three Cities in Cameroon Open
Quality is one of the essential components of medicines and needs to be ensured to preserve the population’s health. This can be achieved through post-marketing quality control of medicines and is one of the most important duties of nation…
View article: User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules
User-Driven Strategy for In Silico Screening of Reversed-Phase Liquid Chromatography Conditions for Known Pharmaceutical-Related Small Molecules Open
In the pharmaceutical field, and more precisely in quality control laboratories, robust liquid chromatographic methods are needed to separate and analyze mixtures of compounds. The development of such chromatographic methods for new mixtur…
View article: Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?
Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022? Open
View article: Investigation of potential substandard dry powder inhalers on EU and North African markets – evaluation of the delivered and fine particle doses
Investigation of potential substandard dry powder inhalers on EU and North African markets – evaluation of the delivered and fine particle doses Open
The FPD of products C and B was, respectively, 17.4 and 14.2% superior to Foradil, products D and H had the closest values compared to the original drug, and product F was 34.5% inferior. Additionally, this work showed that a high FPD can …
View article: Optimizing the soft independent modeling of class analogy (SIMCA) using statistical prediction regions
Optimizing the soft independent modeling of class analogy (SIMCA) using statistical prediction regions Open
View article: Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents
Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents Open
Vibrational spectroscopic techniques, i.e., attenuated total reflectance infrared (ATR-IR), near infrared spectroscopy (NIRS) and Raman spectroscopy (RS), coupled with Partial Least Squares Regression (PLSR), were evaluated as cost-effecti…
View article: A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept
A New Alternative Tool to Analyse Glycosylation in Monoclonal Antibodies Based on Drop-Coating Deposition Raman imaging: A Proof of Concept Open
Glycosylation is considered a critical quality attribute of therapeutic proteins as it affects their stability, bioactivity, and safety. Hence, the development of analytical methods able to characterize the composition and structure of gly…